Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: KEGG:D02003 (NBT)
 1,323 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Using methods of cytochemical investigation of the blood polymorphonuclear leucocytes (PMNL), parameters have been studied, characterizing the systems of biological defence and bioenergetics in patients with dilated cardiomyopathy (DCMP), infectious allergic myocarditis (IAM) and myocarditic cardiosclerosis (MCS). DCMP patients showed depression of NBT--test against the background of the increase in the cationic proteins (CP) level in the blood PMNLs, which was a major cytochemical feature. G-6-PhDG activity was increased in IAM patients against the background of high values of NBT-test. Increased values for G-6-PhDG, CP, phosphatases in the presence of low levels of myeloperoxidase in the blood PMNL suggest chronic inflammatory process in the myocardium. Investigation into the cytochemical parameters of bioenergetic and biological defence of the blood PMNL in patients with DCMP, IAM and MCS permits optimization of the diagnosis and treatment policy in the aforementioned nosological entities.
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PMID:[The cytochemical characteristics of the blood polymorphonuclear leukocytes in dilated cardiomyopathy and an inflammatory myocardial lesion]. 790 Mar 29

41 patients with dilated cardiomyopathy (DCMP), 62 patients with infectious allergic myocarditis (IAMC) and 36 patients with myocarditis cardiosclerosis (MCCS) were examined cytochemically. This involved assessment of the activity of alpha-glycerophosphate- and glucose 6-phosphate dehydrogenases, nicotinamide adenine dinucleotide- and nicotinamide adenine dinucleotide phosphate diaphorases, NBT test parameters, measurements of endogenic cytochrome C and cation protein, activity of acid and alkaline phosphatase, lymphocyte peroxidase and that in peripheral blood polymorphonuclear leukocytes. The findings of the study confirmed a close functional and metabolic relation of the above cytochemical indices. This allows their introduction as additional laboratory criteria in differential diagnosis of inflammatory and idiopathic myocardial affections.
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PMID:[The metabolic characteristics of the blood leukocytes in infectious-allergic myocarditis and dilated cardiomyopathy]. 810 2