Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: KEGG:D02003 (NBT)
 1,323 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The criteria for false positivity of the NBT test were described including absence of classical clinical signs of bacterial infection, negative blood (and, if necessary, other) cultures, and lack of response of antibacterial treatment as the basis for appreciation of positive NBT test result as false-positive. A case of acute lymphoblastic leukaemia with all the criteria being fulfilled was described.
 ...
PMID:Nitroblue tetrazolium (NBT) test: criteria for false positivity and its use in practice. 5 20

The nitro-blue tetrazolium dye reduction test according to modified Park's et al. method in asthmatic children with pollen allergy during remission and status asthmaticus was performed. In patients with status asthmaticus high rate of spontaneous NBT reduction by peripheral phagocytes was found. The routine investigations allowed to exclude bacterial infection as a cause of asthma attacks. It is suggested that allergic reaction may change cellular metabolism providing to increase of NBT reduction.
 ...
PMID:Allergic asthma and NBT dye reduction by granulocytes. 13 95

107 patients and 27 normal individuals underwent the NBT test, as described by PARK et al., in order to ascertain whether it helps to diagnose a bacterial infection. The patients studied consisted of a group with bacterial infections, and a further group suffering from a variety of internal organic diseases of non-bacterial genesis. At the same time, the absolute leucocyte count, the differential blood count, the erythrocyte sedimentation rate, and the leucocyte phosphatase were evaluated. In 84% of the patients with bacterial infections, the values of the NBT test, which are normally between 3 and 14%, were considerably higher, while the value in patients without bacterial infection was only 4% higher than the normal rate. Neither with the leucocyte count, the erythrocyte sedimentation rate, the deviation to the left, nor with the alkaline leucocyte phosphatase was such accuracy obtainable. It is, however, essential that the methodology is closely observed, as even slight changes during the processing can alter the result. The evaluation of the preparations by an experienced analyst is, of course, prerequisite.
 ...
PMID:[Value of the nitroblue tetrazolium test (NBT) in the clinical diagnosis of bacterial infections]. 56 77

The NBT-test was performed in 54 patients with Hodgkin and non-Hodgkin lymphoma showing no bacterial infection exept for one case. 18 patients presented, at onset of the disease, a number of neutrophilic NBT-reducing granulocytes at pathological levels (greater than 12%). In order to evaluate the influence of cytostatic drugs on NBT-test serial blood samples were taken during polychemotherapy in 17 patients with lymphoma. In our experience, cytostatics (COPP) do not necessarily lessen NBT-reducing activity of granulocytes. The results suggest that the NBT in malignant lymphomas could not be used as an indication of bacterial infection.
 ...
PMID:Evaluation of non-stimulated nitroblue-tetrazolium test in patients with malignant lymphomas. 72 24

In order to determine whether immunosupression depresses the response of the NBT test to bacterial infections and to note the effect of allograft rejection on this test, a prospective study was carried out on 30 renal transplant recipients. 12 of 30 renal transplant patients developed bacterial infections and in these patients NBT readings were elevated. 12 of the remianing 18 patients who developed rejection episodes showed normal NBT results. All patients were on high doses of steroids and other immunsuppressive agents. We conclude that the NBT test may be of value in diagnosing bacterial infection in the immunsuppressed allograft recipient, and may also be an useful adjunct in the differentiation between allograft infection and bacterial infection.
 ...
PMID:The qualitative nitroblue tetrazolium (NBT) test as a means to differentiate between infection and rejection in renal transplant patients. 109 15

The clinical value of the NBT test and of leucocyte counts in the aetiological differentiation of acute throat infections was investigated. In our hands a frequency of less than 13% NBT positive neutrophils is considered as normal and a test value above 19% as "positive", i.e. indicating a bacterial infection. More than 19% or more than 1 800 NBT positive neutrophils per mm-3 blood were found in 10 of 18 patients with an infection caused by beta-haemolytic streptococci, in 1 of 2 patients with a Mycoplasma pneumoniae infection and in 1 patient with both a streptococcal and mycoplasmal infection, but in none of 19 patients with a viral infection. Since 8 of 18 patients with streptococcal throat infection had normal NBT test results, the NBT test apparently is of limited value in the early recognition of these infections. A high NBT test value would however support the diagnosis. The white blood cell and neutrophil counts were of little value in the differentiation between streptococcal and viral throat infection.
 ...
PMID:The nitroblue tetrazolium (NBT) test and white blood cell count in acute throat infections. 114 32

An outline of the development of the NBT test is given. The results of studies in a Black population are given and these conform to the pattern published elsewhere, except that a high degree of positivity was found in pulmonary tuberculosis. The value of the test is discussed, and it is concluded that, except in the rare condition of chronic granulomatous disease, the test is of very limited value in the diagnosis of bacterial infection. The test is positive in many situations of stress and may be mediated through a factor in the 'acute phase'.
 ...
PMID:The nitroblue tetrazolium test in Black patients. 117 32

Investigations have shown that the etiology of bacterial endocarditis (BE) has notably changed, with the prevalence of highly virulent agents which alter a course of disease and often determine a lethal prognosis. A positive NBT-test permits more rapid and accurate detection of systemic bacterial infection than investigations of hemoculture, indicates a high phagocytic activity of neutrophils at the active stage of BE irrespective of a course of disease and permits earlier use of antibacterial therapy. A high activity of antibodies to teichoic acids indicated much earlier and more accurately Staphylococcus aureus as an etiological agent than investigations of hemoculture. It permits early etiotropic chemotherapy when it is more effective. Investigations of antibodies to teichoic acids over time makes it possible to assess the effectiveness of therapy of BE as at the inactive stage of disease the test becomes negative. Enzyme immunoassay of antibodies to native and denatured DNA reveals an active autoimmune process in BE patients, ongoing alterative processes--all of them can be used for characterization of a course and prognosis of disease. Etiotropic therapy alters the nature of a BE course, increasing the number of patients with a chronic course of disease in whom remissions are alternated by recurrences.
 ...
PMID:[Bacterial endocarditis: its current course and diagnosis]. 307 Aug 9

In order to determine the contribution of neutrophil malfunction to the phenomenon of enhanced susceptibility of sickle cell disease patients to bacterial infection, the in-vivo neutrophil migration capacity in 23 sickle cell patients and in 14 normal controls; and the neutrophil reduction of nitroblue tetrazolium dye in 74 sickle cell patients and in 78 normal controls were studied. Secondarily the usefulness of the NBT test in distinguishing between osteomyelitis and uncomplicated bone pain was examined. No impairment of neutrophil migratory capacity was evident as no significant difference was observed between the mean migrated neutrophil count in the sickle cell subjects (1.99 X 10(9)/1) and that in normal controls (2.08 X 10(9)/1). The mean NBT scores were 19.9 +/- 8.9% in non-infected controls and 41.3 +/- 14.6% in infected controls (P less than 0.001). In sickle cell disease they were 23.6 +/- 6% in steady state subjects, 29.2 +/- 16.4% in sterile painful crises, 42.9 +/- 15% in non-osteomyelitic bacterial infection (P less than 0.001) and 18.9 +/- 4.2% during osteomyelitis. Thus all sickle cell subjects apart from those with osteomyelitis showed significant increases in the NBT scores during bacterial infection. The low score in sickle cell osteomyelitis is possibly associated with a relative neutrophil phagocytic defect which requires further elucidation. The NBT test was not useful in distinguishing uncomplicated painful crisis from early osteomyelitis in sickle cell disease.
 ...
PMID:In-vivo neutrophil migration and nitroblue tetrazolium reduction in sickle cell disease. 404 66

The reaction of cerebrospinal fluid (CSF) granulocytes in the nitroblue-tetrazolium test (NBT test) was evaluated. In a previous study, methodological problems were resolved, and the method developed by Park et al, was modified to suit the special conditions of the CSF. Thirty-eight CSF specimens from 26 patients were analysed. It appears that NBT test results with CSF granulocytes are significantly positive--according to the criteria developed by Park for blood granulocytes--when bacterial meningitis is present. If the cause of the pleocytosis is not bacterial in nature, then the test results are negative in most cases, provided that the CSF sample contains little or no blood. The NBT test in bloody CSF may produce positive results no matter what the cause of the pleocytosis. Our results suggest that the NBT test is a general, non-specific indicator of granulocyte stimulation. It reflects the ability of granulocytes to react to a stress situation of the organism. Bacterial infection results in a conspicuously large number of stimulated (i.e. NBT positive) granulocytes.
 ...
PMID:The Significance of the nitroblue-tetrazolium test in cerebrospinal fluid granulocytes in bacterial and abacterial meningitis. 702 31


1 2 Next >>