Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: KEGG:D01931 (TiO2)
 11,320 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Analysis method for TiO2 nanoparticles in water and fish samples was set up using ICP-AES after dissolved by solution of sulphuric acid and ammonium sulphate. Meanwhile bioaccumulation of TiO2 nanoparticles was assessed by tests exposing carp (Cyprinus carpio)to TiO2 nanoparticles suspensions. The relative standard deviation (RSD) for water sample of 20.0 mg/L TiO2 is 4.53%, and the recoveries of TiO2 nanoparticles in water and fish samples are raging from 94% - 104% and 90% - 103%, which could ensure accurate measurement of TiO2 nanoparticles. TiO2 nanoparticles have a significant bioaccumulation by the carp, and TiO2 nanoparticles concentrations in carp exposed to 3 mg/L and 10 mg/L TiO2 nanoparticles suspensions for 25 days are 2.1 mg/g and 5.8 mg/g respectively, and the BCF values at equilibrium are 675.5 and 595.4 respectively. Significant As and TiO2 accumulation occurs in viscus and gills of fish, while bioaccumulation of TiO2 nanoparticles in muscle is relative small.
 ...
PMID:[Bioaccumulation of titanium dioxide nanoparticles in carp]. 1711 25

In this study adsorption of Cd onto TiO2 nanoparticles and natural sediment particles (SP) were studied and the facilitated transports of Cd into carp by TiO2 nanoparticles and SP were assessed by bioaccumulation tests exposing carp (Cyprinus carpio) to Cd contaminated water in the presence of TiO2 and SP respectively. The results show that TiO2 nanoparticles had a significantly stronger adsorption capacity for Cd than SP. The presence of SP did not have significant influence on the accumulation of Cd in carp during the 25 d of exposure. However, the presence of TiO2 nanoparticles greatly enhanced the accumulation of Cd in carp. After 25 d of exposure Cd concentration in carp increased by 146%, and the value was 22.3 and 9.07 microg/g, respectively. And there is a positive correlation between Cd and TiO2 concentration. Considerable Cd and TiO2 accumulated in viscera and gills of the fish.
 ...
PMID:Enhanced bioaccumulation of cadmium in carp in the presence of titanium dioxide nanoparticles. 1716 54

Increasing application of nanotechnology highlights the need to clarify and understand nanotoxicity. Mammalian and in vitro studies have raised concerns about the toxicity of titanium dioxide nanoparticles (TiO2-NPs), but there are limited data on ecotoxicity to aquatic organisms. In this work, the sub-acute toxicity of TiO2-NPs to carp (Cyprinus carpio) was assessed. Superoxide dismutase (SOD), catalase (CAT) and peroxidase (POD) activities and lipid peroxidation (LPO) levels in liver, gill and brain tissues of carps varied with concentration of TiO2-NPs suspensions and exposure time (up to 8 d). As a result, 100 and 200 mg/L TiO2-NPs caused statistically significant decrease in SOD, CAT and POD activities and significant increase in LPO levels in tissues (P < 0.05), suggesting that the fish exposed to these two concentrations of TiO2-NPs suffered from the oxidative stress. The extent of depletion of antioxidant enzymes activities and the elevation of LPO in the liver was the greatest, indicating that the liver might be the most susceptible organ to TiO2-NPs exposure. In addition, carps had gill pathologies including edema and thickening of gill lamellae as well as gill filaments, and liver pathologies including necrotic and apoptosis hepatocytes after exposed to 100 and 200 mg/L TiO2-NPs for 20 d. These results indicated a potential risk from TiO2-NPs released into the aqueous environment.
 ...
PMID:Effect of sub-acute exposure to TiO2 nanoparticles on oxidative stress and histopathological changes in Juvenile Carp (Cyprinus carpio). 2000 3