Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: KEGG:D01817 (Iohexol)
 504 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We studied the effect of an ionic high osmolar contrast medium (Ioxitalamate), an ionic low osmolar contrast medium (Ioxaglate) and various nonionic low osmolar contrast media (Iopamidol, Iopromide and Iohexol) on thrombus growth in a rabbit jugular vein thrombosis model. Thrombus growth was determined by the accretion of 125I-labeled fibrinogen onto autologous preformed thrombi in rabbit jugular veins at various time-intervals from 15 min up to 10 h after infusion of the study solution. The ionic low osmolar contrast medium markedly inhibited thrombus growth whereas all nonionic low osmolar contrast media promoted thrombus growth. The ionic high osmolar, contrast medium inhibited thrombus growth, but less than the ionic low osmolar contrast medium. Within the group of nonionic contrast media, the Iopamidol associated promotion of thrombus growth was significantly higher than the Iopromide or Iohexol associated effects. The simultaneous administration of the apparently most potent thrombus growth promoting contrast medium (i.e. Iopamidol) and heparin resulted in complete abolishment of the increase in thrombus growth. These results support the claims of prothrombotic properties of nonionic as compared to ionic contrast media and could explain the clinically encountered thromboembolic complications after the use of nonionic low osmolar contrast media.
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PMID:Variable effects of radiological contrast media on thrombus growth in a rabbit jugular vein thrombosis model. 177 15

A double-blind randomized, clinical trial was conducted in 9 hospitals comparing the use of non-ionic contrast media (CM) iopromide 300 (Ultravist) and iohexol 300 (Omnipaque) during peripheral arteriography in a total of 446 patients. After premedication with morphine-scopolamine each patient was given two consecutive injections of 50 ml CM at a rate of 12 ml/s above the aortic bifurcation. Both CM were well tolerated. There were no differences between the two substances as far as general tolerance, pulse rate, blood pressure, sensation of heat or pain after CM injection were concerned.
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PMID:Comparison of iopromide versus iohexol in aortobifemoral arteriography. A Swedish multi-center study of 446 patients. 203 96

Iodine delivery rates (IDR) of five commonly used non-ionic contrast media were determined at room temperature (24 degrees C) and body temperature (37 degrees C). Contrast media of strength 300 mgI/ml were also evaluated at 50% dilution (150 mgI/ml) with N-saline. Iodine delivery differed significantly (p less than 0.005) between samples at room temperature: Omnipaque 350 (1163 mg/s) less than Niopam 370 (1311 mg/s) less than Omnipaque 300 (1422 mg/s) less than Niopam 300 (1635 mg/s) and Ultravist 300 (1636 mg/s). Niopam 300 and Ultravist 300 delivered 41% more iodine per second than Omnipaque 350 at room temperature. Similar differences were identified at body temperature, while delivery of individual media was on average 23.5% greater than at room temperature. No significant difference between iodine delivery rates of diluted media at room temperature or body temperature was identified. The results demonstrate that iodine delivery and hence vascular opacification are better achieved during hand-injection arteriography by using relatively low viscosity media such as Niopam 300 or Ultravist 300. In digital subtraction arteriography all 300 strength contrast media diluted to 150 strength are equally effective.
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PMID:Non-ionic contrast media: a comparison of iodine delivery rates during manual injection angiography. 203 64

In vivo microscopic (video) investigations on the variability of flow conditions in the myocardium and intestines of anaesthesized normal tension rats after application of various ionic and non-ionic contrast media (Amidotrizoate, Ioxaglate, Iopromide, Iohexol, Iotrolan). Amidotrizoate causes heterogeneous microperfusion and functional shunt vessels (distribution disorder) with the typical symptoms of disturbed microcirculation. Ioxaglate, Iopromide, Iohexol and Iotrolan influence microcirculation differently but always to a far less degree.
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PMID:[Animal experimental studies on the microcirculation of ionic and nonionic x-ray contrast media]. 279 22

After application of various ionic and non-ionic contrast media in the myocardium and intestine of rats, significant changes of flow conditions in the terminal vascular bed were observed with intravital microscopy: Amidotrizoate causes severe disorder in microcirculation distribution (heterogeneous perfusion, functional shunts), while Ioxaglate, Iopromide, Iohexol, Iotrolan cause significantly less microcirculation reactions.
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PMID:[Experimental studies of the vascular reactions in selected microcirculatory areas as affected by various x-ray contrast media]. 279 23

Six widely used X-ray contrast media (XRC) were tested against nine commonly isolated organisms to determine the practicality of using XRC to outline body spaces prior to obtaining specimens for culture and to assess the feasibility of using XRC in divided doses to reduce cost. Preparations of Escherichia coli, Klebsiella pneumoniae, Enterococcus faecalis, Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa, Candida albicans, Streptococcus pyogenes and Streptococcus milleri in two approximate concentrations of 10(4) and 10(8) colony forming units/mL (cfu/mL) were inoculated into the following XRC: Conray 280, Hexabrix 320, lopamiro 370, Omnipaque 350, Ultravist 300 and Optiray 320 each in two concentrations. Sampling was performed in triplicate at 0, 2, 4 and 20 h with the 20 h counts made after exposure at both 22 degrees C and 4 degrees C. There were 16 significant interactions, predominantly with the Gram-negative organisms. Conray 280 produced the greatest number of effects. Most effects were bacteriostatic. Organisms were most susceptible at low concentration and after prolonged contact with XRC. No effect was seen with dilute XRC. All weekly sterility checks were negative. Non-ionic XRC have no significant effect on the growth of Gram-positive organisms and little effect on Gram-negative organisms if processing is performed promptly. Using standard aseptic technique, no contamination of XRC occurred, suggesting multi-dosing may be a safe and cost-effective method of XRC utilization.
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PMID:The effects of X-ray contrast media on bacterial growth. 769 17

It was shown by the method of fluorescent probes that iodine-containing radiocontrast agents Triombrast > Omnipaque > Ultravist > Melitrast increase the content of intracellular Ca2+ in macrophages of the abdominal cavity of rats. Increase in the entry of Ca2+ from the external environment is the main factor of the change in the intracellular concentration of Ca2+ ions in the macrophages in interaction with radiocontrast agents.
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PMID:[The effect of x-ray contrast media on the concentration of intracellular calcium in mononuclear cells]. 1065 May 32

Echinocyte formation is associated with a rigidification of the cells that possibly affects capillary diffusion and, consequently, the tissue's oxygen supply. This study examines how many echinocytes appeared after the addition of various concentrations of radiographic contrast media (RCM) (Iodixanol 320, Iohexol 350, Iopromide 370, Iomeprol 350 and Iomeprol 400 mg Iodine/ml) compared to red blood cells in isotonic saline solution as well as in autologous plasma. Isotonic saline solution, Iodixanol, Iohexol, Iomeprol 350, Iomeprol 400 and Iopromide in concentrations of 10%, 20% or 40% were added to the plasma of six healthy subjects. Subsequently, the erythrocytes were resuspended in these RCM/plasma mixtures, incubated for 5 minutes at 37 degrees C and then examined under the microscope.The various mixtures and concentrations of the RCM in the mixture all had a significant effect on the number of discocytes (p<0.0001). The percentage of discocytes for all concentrations significantly depended on the RCM/plasma mixture (p=0.0097). Of all the RCM/plasma mixtures used as well as of the NaCl/plasma mixtures, the Iodixanol/plasma mixture showed the most similar discocyte fraction compared to red blood cells in the autologous plasma. At the same time, while Iodixanol in this respect differed from all other RCMs, the other RCMs only differed little from one another with respect to the discocyte fraction.
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PMID:The effect of radiographic contrast media on the morphology of human erythrocytes. 1809 53

Various radiographic contrast media (RCM) significantly influence the morphology of erythrocytes, especially the formation of echinocytes [Scand. J. Clin. Lab. Invest. 35 (1975), 1-43; Microvasc. Res. 60 (2000), 193-200; Herz 23 (2003), 35-41]. Microscopic studies, however, have shown that these changes of erythrocyte morphology are possibly reversible [Acta Radiol. 37 (1996), 214-217]. The aim of this study was to proof if the RCM-induced echinocyte formation can be reversed by a resuspension in autologous plasma. In this study four RCMs were tested (Iodixanol, Iohexol, Iomeprol and Iopromide). These RCM induced echinocyte formation (after suspension of erythrocytes in plasma/RCM mixtures for 10 min at 37 degrees C), which was reversible after resuspension in autologous RCM-free plasma (resuspension time 5 min at 37 degrees C). Especially for Iomeprol and Iopromide - the RCMs which induced the strongest echinocyte formation - an echinocyte reduction from 94.2% to 44.5% and for Iopromide from 80.6% to 50.4% occurred. The echinocyte formation was influenced by the type of RCM as well as by the RCM concentration. The same was true for the reversibility of echinocyte formation due to resuspension in autologous plasma (type of RCM: p</=0.0001; concentration of RCM: p=0.0847). Iodixanol was associated with the least numbers echinocytes formed (after suspension in the plasma/RCM-mixture as well as after the resuspension in autologous plasma). A 100% reversibility back to discocytes was observed in none of the RCMs after resuspension in autologous RCM-free plasma.In conclusion, a significant reversibility of RCM-induced echinocyte formation in autologous plasma could be observed.
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PMID:Reversibility of echinocyte formation after contact of erythrocytes with various radiographic contrast media. 1850 36

The intra-arterial application of radiographic contrast media (RCM) can induce decreases of blood flow velocity in downstream capillaries as well as a decrease in the tissue oxygen tension. It is unclear whether changes in endothelial cell morphology contribute to the observed microcirculatory disorders. Four RCMs (Iodixanol320, Iohexol350, Iopromide370, and Imeron350) were added to the culture medium of human umbilical venous endothelial cells (HUVEC) and used for short-term incubation studies of these cells. Addition of Iohexol (p=0.6377) and Iodixanol (p=0.6309) did not affect the HUVEC height 1.5 min after incubation in the modified cell culture media supplemented with 30% v/v of the respective RCM. Strong buckling and increased endothelial height appeared after incubation in Iopromide-supplemented medium (the cell height increased by 95% compared to cells incubated under control conditions; p=0.0065). Addition of Iomeprol-supplemented medium caused an increase by 61.6% compared to cells incubated under control conditions; p=0.0051. After 5 min of incubation in any of the RCM-supplemented media, there was no difference in HUVEC height in comparison to incubation in control standard culture media (each p value>0.05). The tremendous buckling caused by Iopromide and Iomeprol, coinciding with an echinocyte formation of erythrocytes might be the reason why a bolus injection of Iopromide in vivo into the left coronary artery was followed by a 50% decrease of oxygen partial pressure in the supplied tissue.
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PMID:Influence of various radiographic contrast media on the buckling of endothelial cells. 1861 81


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