Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: KEGG:D01453 (caffeine)
 21,611 document(s) hit in 31,850,051 MEDLINE articles (0.02 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
Sep 1533
ATP 688
Mol 634
ryanodine receptor 611
adenosine receptor 534
AMP 419
ATPase 414
CYP1A2 380
phosphodiesterase 374
endoplasmic reticulum 340
insulin 307
cytochrome P450 244
Gen 232
spermatozoa 195
p53 195
calmodulin 180
cardiac muscle 171
microsomal 164
RyR1 164
C18 157
more...
Disease
cancer 667
depression 422
malignant hyperthermia 310
hypertension 285
tumor 250
obesity 231
Parkinson's disease 224
diabetes 212
ATM 210
migraine 178
Alzheimer's disease 167
cold 158
carcinogenesis 148
stroke 118
prematurity 118
ischemia 115
heart failure 104
osteoporosis 98
cardiovascular disease 95
breast cancer 95
more...
Symptom
fatigue 388
pain 334
headache 309
seizures 252
sleepiness 160
anesthesia 142
insomnia 120
exhaustion 100
nausea 70
bitter taste 65
analgesia 63
vomiting 59
overweight 52
hypothermia 51
tremor 49
agitation 43
starvation 35
weakness 32
hypercapnia 32
discomfort 31
more...
Drug
caffeine 21611
Theophylline 147
Cardiovasc 93
Leaf 75
CTX 71
CaCl2 71
CaCl2 70
CaCl2 70
Monit 68
citric acid 67
ascorbate 63
Ethanol 61
Nephron 61
lactose 53
Dermatol 47
vitamin E 45
niacin 42
Mutagen 41
Forskolin 38
lysine 33
more...
Enzyme
ATPase 440
phosphodiesterase 375
protein kinase 297
protein kinase C 182
phospholipase C 138
adenylate cyclase 126
mitogen-activated protein kinase 119
CYP3A4 92
aequorin 80
catalase 71
superoxide dismutase 70
xanthine oxidase 69
creatine kinase 66
N-acetyltransferase 65
adenosine deaminase 61
adenosine deaminase 60
phosphorylase 60
renin 55
calcineurin 53
alkaline phosphatase 51
more...
Compound
caffeine 21611
calcium 4321
water 1864
Dec 1513
DNA 1214
sodium 1138
Clin 910
ATP 690
glucose 620
potassium 534
oxygen 501
ethanol 494
cAMP 484
AMP 437
phosphate 355
Ryanodine 303
noradrenaline 299
Adenosine 298
Mg2+ 277
methanol 260
more...