Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: KEGG:D01430 (Tiopronin)
 68 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Rats were subjected to end-to-end intestinal anastomosis. Breaking strength with the sutures in place, i.e., suture-holding capacity, was measured in different groups immediately after suture and after 24 h. The synthetic kallikrein-plasmin inhibitor S-2441, the inhibitor of plasminogen activation tranexamic acid (Cyklokapron), and the metalloprotease inhibitor tiopronin (Thiola), were studied regarding their effect on breaking strength of the intestinal anastomoses. There was a marked decrease in breaking strength at 24 h in the controls. This decrease was diminished by all of the substances tested. Their effect was probably due to an inhibition of collagenase.
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PMID:Early decrease in suture line breaking strength. The effect of proposed collagenase inhibition. 300 52