Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: KEGG:D01430 (
Tiopronin
)
68
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Accidental radiation exposure raises concern for functional modifications in the uterine physiology. In the current work, total body gamma-irradiation (0.7, 1.4 and 2.1 Gy) of non-pregnant adult female albino rats increased significantly the frequency and amplitude of uterine contractions in vivo. Administration of
Thiola
(a sulfhydryl containing agent) in doses of 100 or 250 mg kg-1, pre-irradiation or Piroxicam (a potent prostaglandin inhibitor) in a dose of 2 mg kg-1, pre- or post-irradiation failed to normalize the changes induced by gamma-irradiation. However, administration of
Diltiazem
(a Ca2+ channel blocker, 8 mg kg-1) pre- or post-irradiation caused a significant decrease in the frequency of uterine contractions (21% and 24% respectively) in comparison to the uterotonic pattern of gamma-irradiation alone. The results indicate a promising tocolytic activity of
Diltiazem
against the uterotonic effect of gamma-radiation.
...
PMID:The effect of thiola, piroxicam and diltiazem on the uterine contractility of gamma-irradiated rats. 907 48
