Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: KEGG:D01311 (Metrizamide)
 591 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A rare case of lumbo-sacral lipoma in an adult case is reported. A 55-year-old male was admitted to the Department of Neurosurgery, Mazda Hospital, after a history of one year of urinary incontinence. Neurologically, no motor or sensory disturbance of the lower extremities was found in this patient. MRI showed a mass with high signal intensity on T2-weighted image, located between L3 to S2 vertebral segments. Metrizamide-CT scan demonstrated the outline of this hypodense mass at the same location as shown on MRI image. A L3 through L5 laminectomy was performed and the tumor was subtotally removed. Microscopic examination revealed that the tumor mass was made up of mature lipoma cells. Postoperative course of the patient was uneventful. The urinary incontinence was improved slightly. No motor or sensory deficit was found. We thought that MRI was useful for the correct diagnosis of lumbosacral lipoma. And it is best managed by operative removal of the tumor as early as possible after it is diagnosed.
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PMID:[An adult case of intradural lumbo-sacral lipoma]. 140 42

A case of Klippel-Feil syndrome with crossed renal ectopia with fusion and unilateral vertebral artery occlusion is reported. A 61-year-old female was admitted because of having developed myelopathy, gait and sensory disturbance. The physical examination on admission revealed spastic gait and hypesthesia of the lower extremities. A hand size, elastic hard tumor mass was palpable at the right lower abdomen. The cervical radiogram showed fused 5th, 6th and 7th cervical vertebrae and severe spondylotic changes. Laminectomy was performed because of severe compressions of the cervical cord, evaluated by Metrizamide CT scans and MRI. The left subclavian angiogram showed occlusion of the left vertebral artery, and excretory pyelogram and abdominal CT scans showed crossed renal ectopia with fusion. 99mTc-DTPA renoscintigram revealed poor RI uptake and low glomerular filtering rate of ectopic kidney. The patients with Klippel-Feil syndrome are at greater risk of having a renal anomaly and a vascular accident of the vertebral artery. Examinations of urogenitary organs and vertebral arteries are necessary for the treatment of this syndrome.
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PMID:[A case of Klippel-Feil syndrome with crossed renal ectopia with fusion and unilateral vertebral artery occlusion]. 202 78

The authors report a case of acute spinal epidural hematoma occurring in a patient receiving antiplatelet drugs. A 76-year-old man with a history of cerebral infarction had been taking antiplatelet agents for one year. He suddenly developed severe back pain which woke him from sleep, and numbness of his lower extremities was then noted. He was hospitalized 15 hours later. Neurological examination revealed flaccid paralysis of both lower extremities with negative Babinski's reflex, and sensory disturbance below the level of L1. The bleeding time and prothrombin time were prolonged. Computed tomographic (CT) scan revealed a biconvex, relatively hyperdense mass in the posterior spinal canal at the level of T12. Metrizamide myelography disclosed an incomplete blockage caused by an epidural mass at the level of T11. Post-myelographic CT scan demonstrated a sharply demarcated extradural filling defect at the level of T11. Seventeen hours after the onset of symptoms, an emergency laminectomy was performed extending from T12 to L3, and the epidural clot was totally evacuated. Histological examination of the capsule of the hematoma revealed no vascular anomalies. The patient made a good postoperative recovery. To the authors' knowledge, this is the first reported case of spontaneous intraspinal hemorrhage in a patient taking antiplatelet drugs. Acute onset of persistent pain anywhere along the spinal axis and the development of spinal neurological deficits in a patient on antiplatelet therapy should raise the suspicion of a spinal epidural hematoma. It should be stressed that prompt neuroradiological diagnosis and rapid surgical decompression are essential to allow good recovery. The present case illustrates that neurological emergencies can occur in patients receiving antiplatelet therapy.
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PMID:[A case of acute spinal epidural hematoma in a patient with antiplatelet therapy]. 279 70

A 42-year-old male was admitted with a one year and two months history of hypesthesia below the epigastric region and gait disturbance. On examination, increased ATR and PTR were bilaterally noticed with sensory disturbance below about Th.5 dermatome level. No cutaneous manifestations were detected on his back. Plain x-ray films showed no spina bifida. Metrizamide myelography showed a space-occupying mass at the Th.5 level. At operation, an extradural tumor, severely adhesived to the dura matter, was totally removed. Histologically, the tumor was composed of fatty tissues, thin-walled vessel spaces and small vessels, diagnosed as spinal hemangiolipoma. Seventeen reported cases of spinal epidural hemangiolipoma were reviewed. Spinal epidural hemangiolipomas occur in the middle aged patients with high incidence and at the mid-thoracic level. There are two types of hemangiolipoma, namely non-infiltrating and infiltrating. In the latter case, a wide excision should be performed to include normal surrounding tissue. In women's cases, particularly during the pregnancy, the fluctuation of the symptoms occurs. The effectiveness of CT and myelography in diagnosing of spinal lipomas was discussed.
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PMID:[Spinal epidural hemangiolipoma - a case report (author's transl)]. 709 74