Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound   Target Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound

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Query: KEGG:D01061 (CPT-11)
1,899 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .

Human Gene/Protein topoisomerase I 236 Sep 153 carboxylesterase 87 DNA topoisomerase I 60 Mol 59 CPT 56 She 48 CEA 47 p53 46 colon carcinoma 39 P-glycoprotein 38 caspase-3 30 UGT1A1 29 APC 24 esterase 23 CES2 22 thymidylate synthase 22 epidermal growth factor receptor 21 ABCG2 21 non-Hodgkin's lymphoma 20 dihydropyrimidine dehydrogenase 20 ATP 19 beta-glucuronidase 19 vascular endothelial growth factor 19 cholesteryl ester hydrolase 18 acetylcholinesterase 17 p21 16 Bcl-2 16 IFN 16 DNA topoisomerase 15 UDP-glucuronosyltransferase 15 PARP 14 breast cancer resistance protein 14 EGFR 14 CYP3A4 14 C18 14 tyrosine kinase 14 GSH 13 cytokine 13 ADM 13 MRI 13 G-CSF 13 1A1 12 BCRP 12 tumor necrosis factor 12 rhabdomyosarcoma 12 MTX 12 PEG 12 intestine, liver 12 CES1 12 HER2 12 VEGF 11 multidrug resistance-associated protein 11 MST 11 canalicular multispecific organic anion transporter 10 ABCC1 10 MDR1 9 AFP 9 TXL 9 pT3 9 gut 9 granulocyte colony-stimulating factor 9 cytochrome P450 9 DNA gyrase 9 NPC 9 ABCB1 8 MRP 8 carcinoembryonic antigen 8 p38 8 hMLH1 8 IRIS 8 FDG 8 CPA 8 UGT1A 8 chromogranin A 8 cyclooxygenase-2 8 glucuronosyltransferase 7 methylguanine-DNA methyltransferase 7 Boc 7 synaptophysin 7 more...

Disease cancer 754 tumor 586 colorectal cancer 351 gastric cancer 220 colon cancer 199 metastases 169 neutropenia 159 carcinoma 152 lung cancer 127 liver metastases 105 adenocarcinoma 93 tumor growth 73 non-small cell lung cancer 70 rectal cancer 63 leukopenia 60 ovarian cancer 51 small cell lung cancer 47 anemia 41 pancreatic cancer 39 thrombocytopenia 37 glioma 36 myelosuppression 35 recurrent gastric cancer 34 lung carcinoma 34 breast cancer 32 lung metastases 32 leukemia 32 primary tumor 29 cervical cancer 26 lymphoma 24 APC 24 tumor progression 22 neuroblastoma 22 non-Hodgkin's lymphoma 21 solid tumor 21 squamous cell carcinoma 19 neuroendocrine carcinoma 18 glioblastoma 17 hepatocellular carcinoma 16 melanoma 14 GSH 13 Gastric Cancer 12 rhabdomyosarcoma 12 sepsis 12 epithelial ovarian cancer 12 glioblastoma multiforme 12 Dukes 11 TAM 11 peripheral neuropathy 11 prostate cancer 11 residual disease 11 carcinomatosis 11 sepsis 10 uterus 10 brain tumor 10 gastrointestinal cancer 10 metastatic breast cancer 10 Small cell carcinoma 9 ileus 9 mesothelioma 9 SCID 9 pneumonia 9 peritonitis 9 metastatic colon cancer 9 NPC 9 MCF 9 sarcoma 8 agranulocytosis 8 measurable disease 8 bone metastases 8 recurrent rectal cancer 8 Hodgkin's disease 8 fibrosarcoma 8 bowel obstruction 7 clear cell carcinoma 7 obstructive jaundice 7 colitis 7 B-cell lymphoma 7 ATM 7 interstitial pneumonia 7 more...

Symptom diarrhea 323 nausea 65 vomiting 59 anorexia 40 fatigue 31 abdominal pain 23 pain 19 nausea and vomiting 16 dyspnea 13 asthenia 10 discomfort 9 discomfort 9 epigastric pain 8 cough 6 constipation 6 Ill 6 chest pain 5 abdominal fullness 4 cachexia 4 headache 3 Severe diarrhea 3 weakness 3 anal pain 3 abdominal cramps 3 flushing 3 colic 2 numbness 2 HSA 2 back pain 2 dizziness 2 collapse 2 hip pain 2 hypothermia 1 insomnia 1 angina 1 myoclonus 1 anesthesia 1 abdominal discomfort 1 dental pain 1 exertional dyspnea 1 night sweats 1 exhaustion 1 tremor 1 hemiplegia 1 splenomegaly 1 bloating 1 sleepiness 1 ataxic gait 1 dysarthria 1 limb pain 1 lethargy 1 regurgitation 1 low back pain 1 paresthesia 1 dysesthesia 1 nasal discharge 1 cancer pain 1 Gastrointestinal symptoms 1 rhinorrhea 1 arthralgia 1 decreased appetite 1

Drug CPT-11 1899 Irinotecan 278 Taxotere 27 Taxol 26 Leucovorin 24 TTC 24 Docetaxel 23 GEO 20 Gemzar 19 Oxaliplatin 16 ADM 14 G-CSF 13 Vinorelbine 12 Navelbine 11 CTX 11 Paraplatin 9 Adriamycin 8 Gefitinib 8 Cetuximab 7 Bevacizumab 7 IFN-gamma 6 Monit 6 VCR 5 Xeloda 5 IL-2 5 Meth 5 VCR 5 Pemetrexed 5 Etoposide 4 Tarceva 3 Isovorin 3 Vorinostat 3 Amiloride 3 MAP 3 Temodal 3 CSF 3 caffeine 3 Alimta 3 EPI 3 Erlotinib 3 lysine 2 BLM 2 DPA 2 Epidoxorubicin 2 Diamminedichloroplatinum 2 TAC 2 Indomethacin 2 CTX 2 CTC 2 CTX 2 Everolimus 2 Bifidobacterium 2 CPM 2 CTC 2 IFN-beta 2 PMPA 1 Flavopiridol 1 THF 1 ADR 1 Indisulam 1 Axitinib 1 Donepezil 1 Metreleptin 1 Vindesine 1 Asn 1 Fulvestrant 1 Albumin 1 Denosumab 1 Glycyrrhiza 1 Telavancin hydrochloride 1 Tenofovir disoproxil fumarate 1 Drotrecogin alfa 1 Ranibizumab 1 ABC 1 Entecavir 1 Genasense 1 Glutathione 1 Pemetrexed disodium 1 Perphenazine 1 Pimecrolimus 1 more...

Enzyme topoisomerase 93 topoisomerase 93 carboxylesterase 92 CPT 56 CPT 56 CPT 56 P-glycoprotein 39 ERK 36 caspase-3 28 UDP-glucuronosyltransferase 25 APC 24 thymidylate synthase 23 dihydropyrimidine dehydrogenase 20 acetylcholinesterase 18 beta-glucuronidase 18 CYP3A4 14 PARP 14 dihydropyrimidine dehydrogenase 12 MDR 9 cholinesterase 8 mitogen-activated protein kinase 6 MTD 6 caspase-9 5 glutathione S-transferase 5 proteasome 5 protein kinase C 4 thymidine kinase 4 luciferase 4 caspase-8 4 NQO1 4 reverse transcriptase 4 caspase-1 4 MEK 3 cytosine deaminase 3 catalase 3 GSK 3 deoxycytidine kinase 3 peroxidase 3 thymidine phosphorylase 3 focal adhesion kinase 3 protein kinase 3 lactate dehydrogenase 3 DCF 2 ribonucleotide reductase 2 DNA methyltransferase 2 ribonucleotide reductase 2 ATPase 2 gamma-glutamylcysteine synthetase 2 CPM 2 tyrosine hydroxylase 2 folylpolyglutamate synthetase 2 polo-like kinase 1 1 alcohol dehydrogenase 1 cdc2 1 TSP-1 1 endonuclease 1 AGT 1 gamma-glutamyl transpeptidase 1 enolase 1 AMPK 1 phosphatidylinositol 3-kinase 1 ornithine decarboxylase 1 trehalase 1 sphingomyelin synthase 1 CPN 1 AMP-activated protein kinase 1 caspase-7 1 deoxyguanosine kinase 1 dihydrofolate reductase 1 trypsin 1 carbonic anhydrase 1 thromboxane synthase 1 ADH 1 CCS 1 carboxypeptidase G2 1 AMPK 1 Alternating 1 glutathione peroxidase 1 choline oxidase 1 caspase-7 1 more...

Compound CPT-11 1882 SN-38 445 5-FU 187 DNA 167 Dec 124 Clin 101 water 84 CPT 56 CPT 56 VP-16 51 DDP 36 MTT 32 folinic acid 31 Camptothecin 30 Camptothecin 30 Camptothecin 30 MMC 28 PEG 24 Leucovorin 24 acetonitrile 22 CBDCA 21 sodium 21 CBDCA 21 Topotecan 20 Topotecan 20 acetate 20 Gemcitabine 19 ATP 19 Gemcitabine 19 5-aminopentanoic acid 18 Paclitaxel 18 ZD1694 17 PEG 16 uridine 16 potassium 15 sulfate 15 Methotrexate 15 phosphate 14 His 14 GSH 13 GSH 13 piperidine 12 ammonium 12 quinoline 12 piperidine 12 MTX 12 quinoline 12 DOC 11 oxygen 11 CTX 11 methanol 11 bromide 11 hydrogen 10 ACNU 10 MDR 9 salt 9 Docetaxel 9 Adriamycin 9 CPA 8 tyrosine 8 bis(2-chloroethyl) 8 pyrimidine 8 CPA 8 CPA 8 CPA 8 pyrimidine 8 bis(2-chloroethyl) 8 bis(2-chloroethyl) 8 A 71 7 TNF 7 VM-26 7 HCl 6 Reserpine 6 Capecitabine 6 ethanol 6 ADP-ribose 6 COS 5 benzil 5 Neo 5 serine 5 more...

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