Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: KEGG:D00527 (Nedocromil sodium)
 190 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

An eight-week multicenter double-masked placebo-controlled group comparison was carried out in 86 patients (age 13-60 years) to determine efficacy and safety of b.i.d. nedocromil sodium 2% ophthalmic solution in ragweed SAC. Treatment was timed to coincide with the predicted ragweed pollen season, taking the two to three weeks of peak pollen counts as the period for analysis. Clinical efficacy was measured from group mean symptom scores (0-4 scale of severity) recorded by the patients on daily diary cards, and the results of clinic examinations made before and after a one-week baseline and following one, three, five and eight weeks of treatment. During the peak pollen season, use of nedocromil sodium reduced all symptoms, with statistically significant differences from placebo, for itching, tearing/watering, overall eye condition and the total symptom summary score (itching+tearing+burning). Clinical assessments of nedocromil sodium showed significant relief of tearing, conjunctival injection and edema. Overall opinions also demonstrated significant benefit with nedocromil sodium, 61% of patients rating active treatment at least moderately effective compared with 36% for placebo (clinicians' opinions were respectively 46% vs 21%). Nedocromil sodium 2% ophthalmic solution b.i.d. caused no major side-effects and was more effective than placebo in relieving major symptoms of SAC.
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PMID:Treatment of ragweed pollen seasonal allergic conjunctivitis (SAC) with b.i.d. nedocromil sodium 2% ophthalmic solution. 2282 86

SAC is caused by allergen interaction with IgE antibody on conjunctival mast cells, leading to local release of vasoactive inflammatory mediators such as histamine. Nedocromil sodium both stabilizes mast cells and has antiinflammatory activity against other cells involved in allergic inflammation. Astemizole is a second generation orally-active H(1)-receptor antagonist with reduced CNS effects such as drowsiness. This multicentre, double blind, double dummy trial compared efficacy and safety of qid 2% nedocromil sodium eye drops with once daily 10 mg oral astemizole, placebo, and combined active treatments for a four-week period. SAC patients (n=207, aged 6-70 years) recorded their symptoms each day on diary cards. Signs and symptoms were also evaluated by clinicians after one, two and four weeks and overall opinions were recorded at the end of treatment. Nedocromil sodium eye drops and astemizole, alone or combined, significantly reduced ocular symptoms compared to placebo (for diary card total symptom score and patients' opinion). Clinicians' opinion showed significantly decreased symptoms with nedocromil sodium, alone or combined, but not with astemizole alone. All treatments were well tolerated, with drowsiness the most frequent side effect observed in patients treated with astemizole. These results demonstrate the effectiveness of nedocromil sodium eye drops in the treatment of SAC.
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PMID:Nedocromil sodium and astemizole, alone or combined, for treatment of seasonal allergic conjunctivitis (SAC). 2282 89