Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: KEGG:D00307 (Doxycycline)
 1,090 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The present study concern in vitro observation on the susceptibility to 20 antibacterial agents of the strains of Flavobacterium meningosepticum from clinical specimens at Juntendo University Hospital during the 1 year period of 1981. The tests for susceptibility of the 144 strains to the drugs were all performed by the serial 2-fold agar plate dilution method on Mueller Hinton agar (Difco), standardized by the Japan Society of Chemotherapy using the Microplanter apparatus with one loop of approximately 10(8) cells/ml. The antibacterial agents tested were as follows: ampicillin, sulbenicillin, piperacillin, mezlocillin, cefazolin, cefmetazole, cefoperazone, cefotaxime, ceftizoxime, kanamycin, gentamicin, tobramycin, amikacin, tetracycline, doxycycline, minocycline, nalidixic acid, pipemidic acid, erythromycin and clindamycin. 1. Thirty-seven per cent of the strains were isolated from sputum, 23% from urine (greater than or equal to 10(5) ml), and 18% from pus and exudate. Only 3 and 2 strains were isolated from cerebrospinal fluid and blood, respectively. 2. A large number of the strains tested were highly resistant to ABPC, SBPC, CEZ, KM, TOB, AMK, PPA and EM, and moderately resistant to PIPC, MZPC, CMZ, CPZ, CTX, CZX, GM, TC and NA. The most of the strains were highly sensitive to MINO, CLDM and DOXY in this order. There was no strain resistant to MINO in this study. 3. The yearly change of the antibacterial activities of DOXY, MINO, CLDM was not significant and 9% of the strains in 1981 were highly resistant to CLDM. The strains resistant to EM were more frequently seen in 1981 than in 1974--1976.
 ...
PMID:[An in vitro study of susceptibility of Flavobacterium meningosepticum to antibiotics]. 655 61

In attempt to elucidate the route and source of Vibrio vulnificus infection. serotyping and drug sensitivity tests of environment-derived strains and human clinical isolates were performed. 1) Serotyping of isolates from the two types of source were determined. Of environment-derived strains, 72.5% were classified into 18 types, and O7 was the most frequent type, accounting for 73.1%, and the second frequent type was O4, accounting for 6.1%. Of human clinical isolates, 87.1% were classified into eight types, and O4 was the most frequent, accounting for 73.5%, and O7 was the secondly most frequent, accounting for 12.9%. 2) Serotypes were investigated by regions. In eastern Japan, 69.2% were classified into 18 types, and O7 and O4 accounting for 44.6% and 5.7%, respectively. In western Japan, 64.8% were classified into eight types, and O7 was the most frequent, accounting for 20.4%, and secondly frequent type was O4, accounting for 11.1%. 3) Regarding the relationship between biotypes and serotypes, environment-derived biotype-I strains were widely distributed in the serotypes, but most biotype-I human clinical isolates were distributed in serotypes O1-O7, showing a difference between the two types of sources. However, many biotype-II strains from the two types of sources included in the serotype O7 group. 4) Drug sensitivity was compared based on MIC90 between strains from the two types of sources. Environment-derived strains were sensitive to ABPC, PIPC, CPZ, CTX, LMOX, MEPM, GM, EM, TC, DOXY, MINO, CP, NA and CPFX, but some strains were resistant to CER, CET, CTX, CMZ, KM and LCM. Human clinical isolates were sensitive to EM, TC, DOXY, MINO, CP, NA and CPFX, but some strains were resistant to ABPC, PIPC, CER, CET, CPZ, CTX, CMZ, LMOX, MEPM, KM, GM, AMK and LCM.
 ...
PMID:[A basic study of Vibrio vulnificus infection: serotyping and drug sensitivity test of environment-derived strains and human clinical isolates]. 1510 98