Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: KEGG:D00285 (Trimethoprim-sulfamethoxazole)
 381 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The susceptibility of Chlamydia trachomatis to antibiotics was studied in vitro and in patients with nongonococcal urethritis. The minimal inhibitory concentrations of cloxacillin, erythromycin, pivampicillin, oxytetracycline, and doxycycline, which were the most effective drugs, were 10, 0.5, 0.25, 0.1, and 0.5 microgram/ml, respectively. The clinical observations suggested that of the antibiotics studied, doxycycline, erythromycin, and trimethoprim-sulfamethoxazole were effective for treatment of chlamydial infection and nongonococcal urethritis. Trimethoprim-sulfamethoxazole seemed less efficient for treatment of patients with nongonococcal urethritis whose cultures were chlamydia-negative. Pivampicillin, although it was active in vitro against C. trachomatis, did not produce a satisfactory clinical response. Untreated patients had symptoms of urethritis and chlamydial infection for three weeks. Incubation periods of a week or less were recorded for about half of the patients who had nongonococcal urethritis, both those whose cultures were chlamydia-positive and those whose cultures were chlamydia-negative. However, a few patients in both groups reported incubation periods of four weeks or more.
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PMID:Susceptibility of Chlamydia trachomatis to antibiotics in vitro and in vivo. 49 40

One hundred male patients with acute gonococcal urethritis were treated with various antibiotic and chemotherapeutic regimens. Pivampicillin, 1400 mg orally in two divided does at 5 hours' interval gave 100% cure in 60 patients. Gentamicin, 280 mg IM in one dose was equally efficaceous in 15 patients. Ampicillin and Trimethoprim-sulfamethoxazole gave cure rates of around 70%. While the results of the first two groups were in agreement with data published in different parts of the world, our results with the later two groups were contrary to those of other authors. The need for periodic evaluation of various antibiotic regimens in the treatment of gonorrhea is indicated.
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PMID:Gonorrhea in the male: some aspects of treatment in Lebanon. 1629 31