Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: KEGG:D00253 (
Sinemet
)
217
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Contrary to a previous report, pretreatment of normal men with carbidopa plus L-dopa (
Sinemet
25/250) markedly inhibited the
PRL
response to TRH, a stimulus that acts directly on the pituitary. Thus, the results of carbidopa/L-dopa testing cannot be used to determine whether agents that stimulate
PRL
secretion act on the pituitary or at a higher central nervous system level.
...
PMID:Carbidopa plus L-dopa pretreatment inhibits the prolactin (PRL) response to thyrotropin-releasing hormone and thus cannot distinguish central from pituitary sites of prolactin stimulation. 308 58
