Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: KEGG:D00107 (Tacrolimus)
 1,665 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
FK506 218
calcineurin 179
calcineurin inhibitor 122
Sep 101
cytokine 65
CYP3A5 62
P-glycoprotein 38
CYP3A4 37
insulin 37
Mol 35
cytochrome P450 32
She 31
IL-2 29
HLA 29
CYP3A 28
phosphatase 27
CD4 25
interferon 22
IL-6 22
ABCB1 20
more...
Disease
atopic dermatitis 150
diabetes 94
graft-versus-host disease 84
hypertension 82
cancer 52
pruritus 48
renal disease 39
psoriasis 36
rheumatoid arthritis 31
ischemia 31
anemia 27
hepatitis C 27
tumor 27
dermatitis 26
skin disease 26
proteinuria 25
systemic lupus erythematosus 23
ulcerative colitis 22
encephalopathy 22
hyperlipidemia 22
more...
Symptom
erythema 26
diarrhea 24
seizures 24
headache 23
pain 13
tremor 13
weakness 11
abdominal pain 10
nausea 9
functional recovery 6
cough 5
shortness of breath 5
Ill 5
myalgia 4
agitation 4
lethargy 4
sleepiness 3
vomiting 3
skin irritation 3
hemoptysis 3
more...
Drug
Tacrolimus 1665
Prograf 166
Dermatol 80
Monit 39
Neoral 32
IL-2 29
Pimecrolimus 20
IFN-gamma 15
TAC 15
Campath 11
Everolimus 11
Campath 11
Daclizumab 9
Basiliximab 8
Basiliximab 8
CSF 8
Cellcept 8
Cellcept 8
CTX 8
Rituximab 6
more...
Enzyme
calcineurin 178
P-glycoprotein 38
CYP3A4 37
peroxidase 14
aspartate aminotransferase 13
alanine aminotransferase 13
superoxide dismutase 7
catalase 7
ERK 6
caspase-3 6
AST 6
creatine kinase 6
alkaline phosphatase 5
lactate dehydrogenase 5
luciferase 5
collagenase 4
acid phosphatase 4
protein kinase C 4
renin 4
BMT 4
more...
Compound
FK506 1564
Clin 196
creatinine 120
Dec 116
Cyclosporine 81
Rapamycin 58
glucose 50
calcium 46
water 46
DNA 39
sodium 32
Mycophenolate mofetil 27
Azathioprine 20
acetate 20
Abbott 16
phosphate 14
TNF 14
urea 13
oxygen 13
PEG 13
more...