Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: HUMANGGP:040116 (
histone
)
44,835
document(s) hit in 31,850,051 MEDLINE articles (0.03 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
histone
44835
Mol
5882
histone H3
4430
histone deacetylase
3841
Sep
2729
H2A
2052
H2B
1766
methyltransferase
1304
histone H4
1300
ATP
1229
histone acetyltransferase
1192
H2AX
1173
p53
1172
RNA polymerase II
1055
p300
978
HDAC1
906
histone methyltransferase
718
histone H1
680
telomeric
676
HDAC
655
thymus
629
cytokine
617
p21
557
DNA methyltransferase
537
CBP
519
ubiquitin
518
Histone deacetylase
505
histone H2A
505
EZH2
493
SET
474
insulin
467
HDAC2
465
NAD
446
acetyltransferase
442
Pol
410
SWI
397
DNase I
394
DNMT1
373
caspase-3
371
histone H2B
368
more...
Disease
cancer
7022
tumor
3710
tumorigenesis
1167
breast cancer
984
carcinogenesis
960
leukemia
836
diabetes
495
prostate cancer
486
systemic lupus erythematosus
475
tumor progression
474
hepatocellular carcinoma
469
acute myeloid leukemia
413
carcinoma
396
ATM
377
tumor growth
361
lung cancer
330
obesity
329
Alzheimer's disease
322
colorectal cancer
298
cold
277
colon cancer
256
HIV
255
glioma
250
lupus
248
SDS
243
MCF
240
melanoma
229
lymphoma
228
lupus
225
adenocarcinoma
196
multiple myeloma
193
HP1
192
gastric cancer
187
glioblastoma
178
retinoblastoma
175
autoimmune disease
174
rheumatoid arthritis
170
type 2 diabetes
169
hypertension
167
squamous cell carcinoma
165
more...
Symptom
starvation
134
pain
89
seizures
77
ataxia
34
collapse
33
fatigue
26
functional recovery
24
exhaustion
23
diarrhea
17
weakness
15
hypotonia
15
splenomegaly
14
anesthesia
14
memory loss
13
hyperoxia
11
nausea
11
arthralgia
10
HSA
9
respiratory distress
9
Neuropathic pain
8
overweight
8
acute stress
8
hypothermia
7
masculinization
7
vomiting
7
skin damage
6
dyspnea
6
cachexia
5
hunger
5
CSR
5
Ill
5
analgesia
5
chills
4
neurological disability
4
anorexia
4
despair
4
insomnia
4
chorea
4
tremor
4
autodigestion
3
more...
Drug
lysine
6253
DNase I
396
Gel
103
ROS
102
Dermatol
88
Vorinostat
84
MOF
66
IL-2
66
IFN-gamma
64
ascorbate
55
caffeine
53
Cardiovasc
47
ETS
46
NADH
45
Mutagen
43
CSF
40
Ethanol
33
MAP
32
Leaf
30
Romidepsin
30
Biopolymers
28
Asthma
28
Retinoic acid
27
CaCl2
26
CaCl2
25
CaCl2
25
FAD
22
GEO
22
p75
22
Asn
21
Fraction
18
ENT
17
Estrogens
16
VCR
16
BLM
15
Adriamycin
15
ICI
14
CDP
13
Monit
13
Alliance
12
more...
Enzyme
RNA polymerase
1451
histone acetyltransferase
1288
protein kinase
1230
demethylase
890
mitogen-activated protein kinase
607
DNA methyltransferase
550
ERK
550
protein kinase C
468
histone demethylase
455
micrococcal nuclease
393
ATPase
340
proteasome
299
luciferase
284
caspase-3
276
PARP
269
trypsin
250
DNase
233
calcineurin
210
topoisomerase
195
topoisomerase
189
focal adhesion kinase
186
cdc2
185
endonuclease
172
AMPK
171
ACS
164
TSA
143
PHD
133
peroxidase
128
Lys4
118
glutathione S-transferase
114
catalase
104
MEK
102
superoxide dismutase
96
DNA polymerase
95
AMP-activated protein kinase
95
alkaline phosphatase
95
RNase
94
phosphorylase
89
lysozyme
84
GSK
82
more...
Compound
DNA
19476
lysine
6776
Dec
2939
Histone
2893
ATP
1230
arginine
1108
sodium
954
oxygen
809
calcium
754
serine
737
Clin
683
salt
641
phosphate
615
glucose
593
NAD
558
SET
474
acetate
453
cAMP
451
NAD
446
tyrosine
411
urea
392
water
386
zinc
378
sulfate
373
threonine
373
ADP
346
ADP
337
ADP
337
AMP
337
methionine
323
retinoic acid
275
hydrogen
268
SDS
264
cysteine
245
adenosylmethionine
235
ADP-ribose
233
DEAE
233
2-oxoglutarate
226
alanine
223
Mg2+
223
more...