Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: HUMANGGP:032343 (LRRK2)
 948 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
LRRK2 948
PINK1 185
SNCA 141
synuclein 123
glucocerebrosidase 118
DJ-1 118
leucine-rich repeat kinase 2 108
Parkin 94
Mol 89
alpha-synuclein 87
parkin 77
GTPase 66
Sep 57
PARK8 51
tau protein 48
PARK7 48
PARK2 48
PARKIN 45
ATP13A2 45
VPS35 45
more...
Disease
Parkinson's disease 826
parkinsonism 128
Alzheimer's disease 54
PARK2 48
movement disorder 42
PARK8 41
dementia 41
Crohn's disease 30
cancer 29
PARK7 22
depression 19
Dementia with Lewy bodies 18
amyotrophic lateral sclerosis 16
leprosy 16
cognitive impairment 15
inflammatory bowel disease 13
PARK6 10
dyskinesia 9
progressive supranuclear palsy 7
Gaucher disease 7
more...
Symptom
tremor 31
bradykinesia 22
dystonia 11
constipation 6
pain 3
motor symptom 3
abnormal gait 2
starvation 2
myoclonus 1
lightheadedness 1
blepharospasm 1
anosmia 1
apathy 1
sleepiness 1
collapse 1
lethargy 1
cerebellar ataxia 1
ataxia 1
pallor 1
ophthalmoplegia 1
more...
Drug
Parkin 94
Parkin 94
ROC 17
ROS 8
caffeine 4
CSF 3
MDS 2
Spectrum 2
vitamin E 2
GEO 2
IPD 2
lysine 2
DBS 1
Gel 1
NADH 1
MAP 1
Pramipexole 1
Dermatol 1
VCR 1
ETS 1
more...
Enzyme
protein kinase 34
mitogen-activated protein kinase 17
glucocerebrosidase 17
ERK 13
proteasome 12
tyrosine hydroxylase 11
focal adhesion kinase 10
complex I 7
ACS 5
superoxide dismutase 5
AMP-activated protein kinase 5
IKK 4
AMPK 4
AMPK 4
luciferase 4
DAT 3
ATPase 3
MEK 3
MEKK1 3
glyceraldehyde-3-phosphate dehydrogenase 3
more...
Compound
leucine 57
Dec 53
DNA 35
GTP 30
calcium 21
Leucine 18
ATP 17
oxygen 17
MPTP 15
threonine 12
TNF 11
serine 10
Clin 9
L-DOPA 9
GDP 8
sodium 8
hydrogen 6
glutamate 6
Neuronal 5
ACS 5
more...