Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: HUMANGGP:031456 (Sep)
 2,027,840 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Mature male rats were rendered cryptorchid and followed for up to nine weeks during which serial blood specimens were obtained for multiple hormonal analyses; serial testicular samples were obtained as well. In contrast with control animals, cryptorchid rats showed transient rises in FSH which returned to normal at the end of the study; estrogen levels were high in the final weeks. Plasma testosterone levels were unchanged and LH levels changed little. Light and electron microscopic studies of testicular biopsy specimens showed prompt disruption of spermatogenesis which became more extensive with time. Sertoli cells underwent multiple changes including increased lipid storage and phagocytosis of spermatozoa. Comparisons are made between the sequence of hormonal changes and that of histological changes. In addition, questions are raised concerning the ways in which Sertoli cells are affected by experimental cryptorchidism.
Anat Rec 1977 Sep
PMID:Experimental cryptorchidism in adult male rats: histological and hormonal sequelae. 2 Aug 20

Mutagenic, DNA-damaging, and in vivo alteration of DNA have been demonstrated for 1,2-dimethylhydrazine (DMH), a potent inducer of adenocarcinomas of the large intestine and colon of rats. These activities are pH-dependent, with 6.5 giving optimum response. There was no requirement for metabolic activation with rat-liver S9 mix when the appropriate Bacillus subtilis mutant strains were used. The Rec- strains recA8 and mc-1 were greater than 300-fold more sensitive to the DNA-damaging activity of DMH than was their isogenic wild-type parent. The DNA isolated from DMH-treated mc-1 had altered spectroscopic characteristics, and gave a greatly reduced transformation efficiency. Treatment of B. subtilis strain TKJ6321 with DMH at pH 6.5 induced His+, Met+ mutations in substantial numbers at low concentrations of this chemical. The use of B. subtilis mutants in these studies has therefore made it possible to demonstrate mutagenic and DNA-damaging activity in bacteria for this potent carcinogenic chemical.
Mutat Res 1979 Sep
PMID:DNA-damaging and mutagenic effects of 1,2-dimethylhydrazine on Bacillus subtilis repair-deficient mutants. 4 Jan 24


Anat Rec 1979 Sep
PMID:Proceedings of the American Association of Anatomists. Ninety-second Meeting. University of Miami. School of Medicine. April 2, 3, 4, 5 1979. 4 Apr 59

Normal swine testes, congenital cryptorchid swine testes, and normal human tests were exposed to HMM (heavy meromyosin) after either glycerination or saponin treatment in order to determine whether the fine filaments composing the crystalloids in the Sertoli cells of the cryptorchid swine testes bind HMM to form arrowhead complexes. Short bundles of microfilaments observed in the basal part of the Sertoli cells in both normal and cryptorchid testes also bind HMM. Similar bundles of HMM-bound filaments are observed in the vicinity of spermatocytes. The periodicity of the arrowhead complexes is about 35 nm, and all arrowheads on a given filament point in the same direction. In addition, the polarity of the HMM-bound filaments in a given crystalloid or bundle is uni-directional. A mechanism for the formation of the swine crystalloids has been strongly support this hypothesis. Fine filaments of Charcot-Boettcher's crystalloid in human Sertoli cells did not bind HMM. Therefore the fine filaments of the human crystalloid are not actin-like in nature.
Anat Rec 1979 Sep
PMID:Crystalloids of actin-like filaments in the Sertoli cell of the swine testis. 4 Apr 60


Vet Rec 1979 Sep 15
PMID:BVA Congress: Government criticised over schools' problems. 4 86


Vet Rec 1979 Sep 01
PMID:Looking forward. 4 90


Vet Rec 1979 Sep 01
PMID:Animal production conference. 4 91


Vet Rec 1979 Sep 01
PMID:Rapeseed meal and liver damage: effect on plasma enzyme activities in chicks. 4 92


Anat Rec 1977 Sep
PMID:Light and electron microscopic histochemistry of the serous secretory granules in the salivary glandular cells of the mongolian gerbil (Mongolian meridianus) and rhesus monkey (Macaca irus). 7 67

Epiphyseal growth plate chondrocyte nuclei of growing rats were studied for histone content using the ammoniacal silver technique. This stain, which is specific for the demonstration of the arginine-rich fractions of histones, revealed that growth plate nuclei vary in their histone content. Nuclei of cells of the proliferating zone revealed a significantly greater amount of postformalin ammoniacal silver deposit consistent with the presence of arginine-rich histones.
Anat Rec 1979 Sep
PMID:Ultrastructural localization of histones in epiphyseal chondrocytes. 9 33


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