Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: HUMANGGP:018823 (BACE1)
 2,296 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
BACE1 2296
amyloid precursor protein 1141
APP 321
amyloid beta 217
BACE 208
aspartyl protease 204
Mol 196
precursor protein 134
Sep 126
PS1 114
memapsin 2 102
ADAM10 100
acetylcholinesterase 90
membrane-bound 68
axonal 63
endoplasmic reticulum 61
presenilin 1 61
cathepsin D 57
insulin 49
butyrylcholinesterase 48
more...
Disease
Alzheimer's disease 1773
plaque 147
dementia 143
neuroblastoma 116
cognitive impairment 101
memory impairment 49
diabetes 38
amyloidosis 33
Down syndrome 29
SAR 22
stroke 20
cancer 18
schizophrenia 17
obesity 14
vascular disease 14
GSH 14
type 2 diabetes 13
cerebral ischemia 13
SDS 13
hypercholesterolemia 12
more...
Symptom
memory loss 26
seizures 11
functional recovery 4
collapse 4
anesthesia 4
pain 3
spasticity 2
ataxia 2
thinning 2
starvation 1
Sedation 1
hypocapnia 1
HSA 1
general problem 1
despair 1
stigma 1
analgesia 1
agitation 1
Fluctuation 1
Spastic paraparesis 1
more...
Drug
CSF 40
lysine 14
ROS 14
Asn 8
Fragment 5
vitamin E 4
Scopolamine 3
FAD 3
p75 3
caffeine 3
Gel 3
nitroglycerin 3
Itraconazole 2
Gleevec 2
Glycyrrhiza 2
Imatinib 2
Glide 2
ABC 2
Ethanol 2
Glucagon 2
more...
Enzyme
beta-secretase 863
acetylcholinesterase 98
cholinesterase 68
cathepsin D 46
protein kinase 45
CD10 45
mitogen-activated protein kinase 39
memapsin 2 36
protein kinase C 31
insulin-degrading enzyme 30
ERK 28
GSK 26
proteasome 24
pepsin 21
caspase-3 21
ACS 19
TACE 19
superoxide dismutase 19
cathepsin B 17
luciferase 16
more...
Compound
Dec 151
water 117
Asp 61
hydrogen 60
DNA 44
oxygen 44
calcium 39
TNF 34
leucine 32
alanine 30
glucose 29
methionine 28
tyrosine 28
lysine 27
glutamate 26
cysteine 22
nitric oxide 21
ACS 19
ACS 19
TACE 19
more...