Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: HUMANGGP:015150 (cyclin-dependent kinase)
 5,526 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
cyclin-dependent kinase 5526
cyclin 1533
p21 1235
p27 975
Mol 771
p53 642
cyclin D1 552
CDK2 494
cyclin E 475
CDK4 444
p16 385
Sep 383
cyclin A 347
WAF1 191
cyclin D 189
CDK6 185
CIP1 184
pRb 183
INK4a 178
proliferating cell nuclear antigen 172
more...
Disease
cancer 1323
tumor 981
retinoblastoma 628
breast cancer 293
tumorigenesis 215
carcinoma 167
carcinogenesis 148
tumor growth 136
leukemia 120
prostate cancer 112
hepatocellular carcinoma 102
melanoma 93
Alzheimer's disease 92
tumor progression 88
MCF 86
squamous cell carcinoma 76
colon cancer 73
lung cancer 62
lymphoma 61
adenocarcinoma 57
more...
Symptom
starvation 47
collapse 11
seizures 9
exhaustion 6
diarrhea 6
pain 6
fatigue 4
nausea 4
hypotonia 3
ataxia 3
memory loss 3
functional recovery 3
vomiting 3
splenomegaly 3
thinning 2
ENT 1
sore throat 1
DNA marker 1
abnormal gait 1
spasticity 1
more...
Drug
lysine 46
Flavopiridol 34
IL-2 19
ICI 15
Dermatol 15
Bortezomib 13
ROS 12
MAP 12
IFN-gamma 11
caffeine 10
Lovastatin 7
Estrogens 7
Gefitinib 6
Angiotensin II 5
Retinoic acid 4
vitamin E 4
Purvalanol 4
Herceptin 4
Monit 4
ascorbate 4
more...
Enzyme
protein kinase 5526
cdc2 855
mitogen-activated protein kinase 345
ERK 168
proteasome 165
RNA polymerase 149
caspase-3 123
protein kinase C 82
calcineurin 75
MEK 72
PARP 58
phosphatidylinositol 3-kinase 57
APC 54
GSK 48
luciferase 47
focal adhesion kinase 47
caspase-9 44
polo-like kinase 1 42
protein phosphatase 2A 30
glutathione S-transferase 25
more...
Compound
DNA 1191
Dec 402
threonine 234
serine 170
tyrosine 135
ATP 112
oxygen 107
Clin 100
alanine 79
phosphate 69
calcium 66
lysine 60
cAMP 58
MTT 55
glucose 52
retinoic acid 50
MDA 48
urea 44
proline 44
MEK 43
more...