Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: HUMANGGP:003517 (MEK)
 12,715 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
MEK 12715
ERK 5327
MAPK 2466
ERK1 2032
BRAF 1624
PI3K 1403
Mol 1335
p38 1250
MAP kinase 1162
extracellular signal-regulated kinase 1148
MEK1 1004
AKT 926
RAF 900
Sep 875
mitogen-activated protein 865
JNK 725
mTOR 719
Raf-1 639
tyrosine kinase 562
ERK2 487
more...
Disease
cancer 2946
tumor 2087
melanoma 1135
breast cancer 440
tumor growth 430
tumorigenesis 396
metastatic melanoma 324
carcinoma 312
colorectal cancer 274
hepatocellular carcinoma 272
lung cancer 268
leukemia 248
tumor progression 232
adenocarcinoma 218
carcinogenesis 211
Melanoma 203
metastases 193
non-small cell lung cancer 184
pertussis 173
pancreatic cancer 155
more...
Symptom
pain 83
starvation 41
fatigue 25
diarrhea 24
nausea 20
seizures 19
collapse 9
vomiting 8
headache 8
analgesia 6
hypothermia 6
splenomegaly 5
arthralgia 5
dyspnea 4
functional recovery 4
cachexia 4
weakness 4
orofacial pain 4
hyperoxia 4
anesthesia 3
more...
Drug
MAP 309
Dermatol 109
ROS 94
Sorafenib 72
IL-2 63
CSF 60
lysine 50
ICI 39
Angiotensin II 38
IFN-gamma 32
NVP 27
ETS 24
Gel 19
Cardiovasc 19
Monit 18
Forskolin 18
Arsenic trioxide 16
Ipilimumab 16
Taxol 15
Gefitinib 15
more...
Enzyme
MEK 12715
mitogen-activated protein kinase 6851
ERK 5878
protein kinase 1702
protein kinase C 914
focal adhesion kinase 479
phosphatidylinositol 3-kinase 444
MEKK1 357
MAP 303
caspase-3 248
luciferase 226
phosphoinositide 3-kinase 174
calcineurin 155
phospholipase C 132
proteasome 123
PARP 122
cdc2 116
GSK 94
IKK 81
AMPK 73
more...
Compound
MEK 11589
DNA 975
Dec 907
tyrosine 842
calcium 454
oxygen 432
threonine 407
serine 395
cAMP 339
acetate 315
MAP 305
Clin 283
glucose 228
ATP 215
sodium 160
GTP 156
nitric oxide 150
MTT 145
TNF 138
methionine 137
more...