Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: HUMANGGP:001715 (parkin)
 1,310 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
parkin 1310
Parkin 359
ubiquitin 336
PINK1 247
alpha-synuclein 223
Mol 168
E3 ubiquitin ligase 153
PARK2 145
proteasome 145
DJ-1 132
Sep 96
PTEN 96
synuclein 87
PARKIN 82
ubiquitin ligase 81
LRRK2 77
endoplasmic reticulum 54
LC3 47
PARK6 42
p62 42
more...
Disease
Parkinson's disease 931
parkinsonism 359
PARK2 145
Alzheimer's disease 74
dementia 50
movement disorder 36
neuroblastoma 31
cancer 30
PARK6 27
amyotrophic lateral sclerosis 22
PARK7 21
tumor 20
Huntington's disease 17
IBR 13
GSH 13
Dementia with Lewy bodies 13
dyskinesia 12
progressive supranuclear palsy 11
PARK1 10
OPA1 10
more...
Symptom
dystonia 32
tremor 24
bradykinesia 14
starvation 7
ataxia 5
constipation 3
myoclonus 3
pain 3
collapse 2
motor symptom 2
weakness 2
seizures 1
dry eye 1
dizziness 1
vomiting 1
skin damage 1
consciousness disturbance 1
sleepiness 1
ophthalmoplegia 1
paraparesis 1
more...
Drug
Parkin 359
Parkin 359
ROS 27
lysine 10
CSF 3
vitamin E 3
BH4 3
Indomethacin 2
NADH 2
MRC 1
RFP 1
TTC 1
TiO2 1
Captopril 1
Zonisamide 1
ZnO 1
LCM 1
Angiotensin II 1
caffeine 1
Monit 1
more...
Enzyme
proteasome 145
complex I 38
tyrosine hydroxylase 38
ubiquitin-protein ligase 36
protein kinase 30
mitogen-activated protein kinase 24
isopeptidase 18
glucocerebrosidase 12
MPP 11
AMP-activated protein kinase 11
monoamine oxidase 10
superoxide dismutase 10
caspase-3 10
ERK 8
Omi/HtrA2 8
AMPK 7
luciferase 7
PARP 6
ATP synthase 6
glutathione S-transferase 6
more...
Compound
Dec 86
oxygen 80
DNA 66
MPTP 42
ATP 37
cysteine 28
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 26
iron 20
calcium 20
leucine 17
TNF 17
CHIP 17
cyanide 16
nitric oxide 15
hydrogen 15
glucose 15
CCP 14
L-DOPA 14
lysine 14
GSH 13
more...