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Query: HUMANGGP:001372 (ESR)
 7,313 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Samples of Walker 256 carcinoma grown in muscles of Sprague-Dawley rats were studied at low temperatures before and after lyophilization. The effects of lyophilization on the ESR spectra were different for tumours and normal muscle. Prior to lyophilization of a tumour sample, there was a decrease in free radicals, while after the lyophilization, there was an "increase". The "increase" was due to the lyophilized tumour having a narrower line, producing a greater peak-peak height measurement than in muscle, without an increase in the total number of spins. Exposure of lyophilized samples to air produced an increase in the intensity of the spectra and a change in line shape; also these effects differed for tumour and muscle. Mn++ levels were lower in tumour than in muscle, a difference eliminated by lyophilization. Poor growth conditions in tumours increased the occurrence of ESR spectra due to NO complexes with both heme and non-heme iron proteins. These results may help to resolve the principal controversies about experimental findings in ESR of tumours. At least part of the signals seen after lyophilization do not reflect free radicals in vivo. The signals after lyophilization reflect biochemical differences between tumour and muscle; spectroscopic data indicate that it is feasible to determine the molecular basis of these differences.
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PMID:Paramagnetic changes in cancer: growth of Walker 256 carcinoma studied in frozen and lyophilized tissues. 21 82

Matched normal/tumor DNA pairs from patients with sporadic and hereditary (FAP = familial adenomatous polyposis) colorectal carcinoma were examined for tumor-specific allele loss on chromosome 6 using cDNA probes for the avian myeloblastosis viral oncogene homologue (MYB on 6q22-q23), the estrogen receptor (ESR on 6q24-q27), and for the alpha polypeptide of human chorionic gonadotropin (CGA on 6q14-q21). No chromosome 6 allele loss was observed at these gene loci among 22 colorectal carcinomas examined, although such losses were relatively frequent (37.5% of informative individuals) at the D17S28 locus on chromosome 17. These results are consistent with karyological studies and indicate that chromosome 6 allele loss from colorectal carcinomas may occur less frequently than previously reported.
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PMID:A study of chromosome 6 allele loss in human colorectal carcinomas. 133 82

A 79-year-old housewife complaining of shortness of breath presented with a LUL mass lesion on chest roentgenogram. Bronchofiberscopic biopsy and curettage revealed adenocarcinoma as well as acid-fast bacilli of Gaffky-4. Further investigations showed increased ESR, CRP levels and positive RF. PPD skin test was positive measuring 55 x 43 mm. A left upper lobectomy with mediastinal lymph node dissection was performed. The mass was in S1+2 and measured 2.7 x 2.5 x 1.5 cm. Histologically caseaous necroses and spotted granulomas of tuberculosis were surrounded by bronchioloalveolar cell carcinoma. Recent discussion concerning the simultaneous occurrence of pulmonary tuberculosis and bronchogenic carcinoma suggests a higher coexistence of both diseases. However, the coexistence of active tuberculosis with carcinoma in the same region, as in our case, is quite rare and suggests an etiological closer relationship between both diseases.
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PMID:[A case of coexistent bronchogenic carcinoma with pulmonary tuberculosis]. 159 38

A total of 96 cases of renal carcinoma with distant metastasis at the time of diagnosis was studied. The patients were classified into 4 groups: Group O (16) in whom nephrectomy was not performed, Group A (51) who died due to carcinoma within 1 year of nephrectomy, Group B (25) who died due to carcinoma 1 to 3 years after nephrectomy, and Group C (4) who survived for 3 years or more after nephrectomy. Six clinical measurements were evaluated: haemoglobin, ESR, alpha 2 globulin, temperature, weight and C reactive protein. In addition, performance status, the number of organs with metastases, number of metastatic lesions and tumour growth rate were measured. The results showed that in patients surviving for 1 year or more after nephrectomy, there was an abnormality in the results of 3 or less of the 6 clinical measurements, performance was 0 or 1, and the carcinoma had metastasised to only one organ. In addition, it was found that the growth of metastatic lesions in patients who survived for 3 years or more was much slower than in the other patients. Nephrectomy was found to be effective in only 27% of our cases and we consider that careful deliberation should be made pre-operatively as to whether nephrectomy is really necessary in patients with metastasis. The decision should be made on the basis of the results obtained in the 6 clinical measurements given above.
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PMID:Nephrectomy in renal carcinoma with distant metastasis. 275 52

Bronchiolitis obliterans organizing pneumonia (BOOP) is a pathologic finding common to various injuries to the lung of either definite or idiopathic etiology. Since the presentation of patients with idiopathic BOOP varies, we studied 16 patients with BOOP on pulmonary histology to define more distinct and homogeneous clinical and imaging profiles of idiopathic BOOP. We distinguished three groups of patients: group 1 (n = 4), with multiple patchy migratory pulmonary involvement of the pneumonia type. Their clinical course was subacute, with cough, fever, weight loss, mild dyspnea, and increased ESR. Chest x-ray film and CT scan showed multiple alveolar opacities. All patients completely recovered with corticosteroid therapy but relapsed when therapy was stopped too rapidly. Group 2 (n = 5) had solitary pulmonary involvement of the pneumonia type occurring in a similar clinical context. Since carcinoma was suspected, they underwent surgical excision of the pneumonic area and recovered without relapse. Group 3 patients (n = 7) presented with diffuse pulmonary involvement of the interstitial lung disease type. They had more progressive onset of more severe dyspnea, crackles heard over all lung surfaces, and interstitial opacities with or without alveolar opacities on chest imaging. Improvement with corticosteroid therapy was obtained in only three patients. In all three groups, lung function test results showed a restrictive pattern. The obstructive pattern characteristic of pure bronchiolitis obliterans was found in none. BAL showed a mixed pattern (increase of both lymphocytes and polymorphonuclear cells) in the patients of the first two groups. Thus, we distinguished three characteristic clinical and imaging profiles in patients with idiopathic BOOP: multiple patchy pneumonia, solitary pneumonia, and diffuse interstitial lung disease. These profiles are so different that they should be distinguished in clinical studies of idiopathic BOOP.
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PMID:Idiopathic bronchiolitis obliterans organizing pneumonia. Definition of characteristic clinical profiles in a series of 16 patients. 280 73

CA125 is a new unique tumor marker for epithelial ovarian cancer, and its clinical use has recently increased considerably. We have periodically monitored 14 cases of ovarian cancer (7 cases of serous cystadenocarcinoma, 4 cases of clear cell carcinoma, 1 case of endometrioid carcinoma and 1 case of metastatic ovarian cancer) using CA125, before and after surgery, during chemotherapy, and in follow-up. The serum CA125 was measured with a radioimmunoassay kit. As a result of this monitoring, we have discovered the following facts: The ten cases in which the titer of CA125 dropped to 35U/ml, which is cut off, by 60 days after surgery, when we had finished 2 courses of chemotherapy, showed good progress. In contrast to this, in the other cases, the degree of CA125 was still high 60 days after the surgery and did not drop after that. In these 4 cases, the tumor growth was found. It was therefore concluded that with this method a prognosis could be made much earlier than with the current system, and that relapse could be detected far earlier. We have also examined the mutual relations between CA125 and other tumor markers, IAP, TPA, HBDH, CEA, Ferritin, alpha 1AT, ESR, and LDH. Although we could see some usefulness in periodic monitoring with IAP, unlike CA125 it did not reflect the condition of a disease. The coefficients of correlations between CA125 and other tumor markers are as follows: IAP 0.5268, TPA 0.4541, HBDH 0.4551, CEA 0.2942, Ferritin -0.1005, alpha 1AT 0.5321, ESR -0.0619, LDH 0.5994.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Serum CA125 in malignant ovarian tumor--periodical monitoring and correlation with other tumor markers]. 345 77

ESR and serum concentrations of IgG, IgA, IgM, C3, C4, C1-INH and CEA were quantified preoperatively in 195 patients with gastric carcinoma. The values were grouped according to the extent of disease (T1-3N0M0, T2-3N + M0, T4AnyNM0, AnyTAnyNM1) and according to the histological type of tumor (intestinal-type, diffuse and unclassifiable). The data were analysed using a two-way analysis of variance with unequal cell sizes. ESR, C4, C1-INH, IgG and CEA varied with the extent of disease. When the data were adjusted for this variation, we found that the values of ESR, C4 and CEA were different between the various histological types. The values were highest in patients with the intestinal-type tumor and lowest in those with diffuse tumor. The concentrations of IgG and C1-INH were not different between the histological types. Our results are relevant when ESR, C4 and CEA are used in the evaluation of patients with gastric carcinoma.
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PMID:Concentrations of serum proteins and erythrocyte sedimentation rate in patients with different histological types of gastric carcinoma. 359 83

In 195 patients with gastric carcinoma the preoperative ESR and serum concentrations of IgG, C4, C1-INH and CEA varied significantly with the extent of disease. Extent of disease and prognosis were predicted from these variables by discriminant analysis. The discriminant rules were tested on the same patients in an unbiased way. Metastases or no metastases were correctly predicted in 75% of the patients. By an appropriate prior distribution 93% of the patients without metastases were identified. The disease extent was also predicted in subgroups of patients with and without metastases. Survival was correctly predicted preoperatively in 66% of the patients and 83% of the patients with a fair prognosis were identified. Of the patients preoperatively allocated to the non-survival group 94% did actually die during follow-up. When used in addition to other available information, our discriminant rules will contribute to the quality of the preoperative evaluation of patients with gastric carcinoma.
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PMID:Preoperative prediction of extent and prognosis of gastric carcinoma by four serum proteins and erythrocyte sedimentation rate. 362 81

In a group of patients with colorectal carcinoma and a control group the problem was investigated whether or not the 2-hour-value of the erythrocyte sedimentation rate yields additional information. The 2-h-rate of ESR turns out to have a higher sensitivity than the 1-h-value. One should, therefore, continue to measure both the 1-h- and 2-h-value of ESR.
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PMID:[Blood cell sedimentation rate--is the 2-hour value still necessary?]. 368 44

Sinus histiocytosis with massive cervical lymphadenopathy (SHML) was originally described in 1969 as a benign clinicopathologic entity characterized by massive bilateral cervical lymphadenopathy, fever, leukocytosis, elevated ESR, and hypergammaglobulinemia, usually occurring within the first two decades of life. We present an illustrated case of an elderly patient with polyclonal hypergammaglobulinemia and a 2-year history of multilobulated cervical and submandibular lymphadenopathy. The etiology and pathogenesis of SHML are not known. Diagnosis requires lymph node biopsy to exclude other causes of cervical lymphadenopathy such as malignant lymphoma, malignant histiocytosis, metastatic carcinoma, and tuberculous lymphadenitis. Histologic examination shows marked dilatation of subcapsular and medullary lymph node sinuses containing large, foamy or vacuolated histiocytes. Although no curative treatment is known, corticosteroids, radiation therapy, vinblastine and oral cyclophosphamide, and surgery have been used to palliate constitutional symptoms and mechanical obstruction from massive lymphadenopathy. Since one third of SHML patients have evidence of disease for 5 years, and a mortality rate of 7% exists with benign histologic disease, all patients with SHML should be carefully screened for evidence of immunodeficiencies that may precipitate a fatal outcome.
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PMID:Sinus histiocytosis with massive cervical lymphadenopathy. Case report and literature review. 374 Jul 6


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