Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: HUMANGGP:000090 (tyrosine kinase)
36,253 document(s) hit in 31,850,051 MEDLINE articles (0.03 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
tyrosine kinase 36253
epidermal growth factor receptor 4460
Mol 2855
Sep 2529
EGFR 2251
insulin 1730
ABL 1408
BCR 1376
epidermal growth factor 1274
insulin receptor 1221
receptor tyrosine kinase 1213
vascular endothelial growth factor 1183
ATP 1117
cytokine 1114
EGF receptor 1047
EGF 853
HER2 801
MAPK 767
ERK 752
c-Src 728
more...
Disease
cancer 8108
tumor 5430
chronic myeloid leukemia 3291
lung cancer 2323
non-small cell lung cancer 2230
leukemia 1591
ABL 1408
breast cancer 1315
adenocarcinoma 1018
tumor growth 927
carcinoma 862
metastases 798
acute myeloid leukemia 769
tumorigenesis 727
renal cell carcinoma 627
hypertension 619
acute lymphoblastic leukemia 617
lung carcinoma 588
tumor progression 537
lymphoma 503
more...
Symptom
diarrhea 339
fatigue 171
pain 167
nausea 97
weakness 72
dyspnea 62
starvation 60
splenomegaly 58
vomiting 48
seizures 44
anorexia 38
collapse 35
cough 34
headache 33
abdominal pain 28
functional recovery 21
respiratory distress 20
erythema 20
hemoptysis 19
asthenia 19
more...
Drug
Imatinib 925
Gefitinib 619
Gleevec 544
Erlotinib 348
Dasatinib 224
IL-2 210
Dermatol 173
CSF 170
MAP 170
Sorafenib 166
lysine 137
Herceptin 126
p75 120
Tarceva 108
IFN-gamma 103
Bevacizumab 96
Cardiovasc 95
Cetuximab 95
ROS 95
Angiotensin II 79
more...
Enzyme
ERK 7100
focal adhesion kinase 3403
mitogen-activated protein kinase 2885
protein kinase C 2035
protein kinase 1672
MEK 779
phospholipase C 733
phosphatidylinositol 3-kinase 649
caspase-3 230
thrombin 224
phosphoinositide 3-kinase 217
proteasome 205
luciferase 196
ATPase 191
glutathione S-transferase 162
calcineurin 155
PTPase 154
MAP 150
phospholipase D 149
reverse transcriptase 138
more...
Compound
tyrosine 8276
Dec 2622
DNA 2332
calcium 1870
Clin 1727
ABL 1408
BCR 1376
ATP 1117
serine 929
methionine 872
threonine 816
glucose 672
oxygen 657
acetate 573
Tyrosine 526
MEK 511
cAMP 499
sodium 476
Insulin 474
phosphate 457
more...