Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: HUMANGGP:000090 (
tyrosine kinase
)
36,253
document(s) hit in 31,850,051 MEDLINE articles (0.03 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
tyrosine kinase
36253
epidermal growth factor receptor
4460
Mol
2855
Sep
2529
EGFR
2251
insulin
1730
ABL
1408
BCR
1376
epidermal growth factor
1274
insulin receptor
1221
receptor tyrosine kinase
1213
vascular endothelial growth factor
1183
ATP
1117
cytokine
1114
EGF receptor
1047
EGF
853
HER2
801
MAPK
767
ERK
752
c-Src
728
more...
Disease
cancer
8108
tumor
5430
chronic myeloid leukemia
3291
lung cancer
2323
non-small cell lung cancer
2230
leukemia
1591
ABL
1408
breast cancer
1315
adenocarcinoma
1018
tumor growth
927
carcinoma
862
metastases
798
acute myeloid leukemia
769
tumorigenesis
727
renal cell carcinoma
627
hypertension
619
acute lymphoblastic leukemia
617
lung carcinoma
588
tumor progression
537
lymphoma
503
more...
Symptom
diarrhea
339
fatigue
171
pain
167
nausea
97
weakness
72
dyspnea
62
starvation
60
splenomegaly
58
vomiting
48
seizures
44
anorexia
38
collapse
35
cough
34
headache
33
abdominal pain
28
functional recovery
21
respiratory distress
20
erythema
20
hemoptysis
19
asthenia
19
more...
Drug
Imatinib
925
Gefitinib
619
Gleevec
544
Erlotinib
348
Dasatinib
224
IL-2
210
Dermatol
173
CSF
170
MAP
170
Sorafenib
166
lysine
137
Herceptin
126
p75
120
Tarceva
108
IFN-gamma
103
Bevacizumab
96
Cardiovasc
95
Cetuximab
95
ROS
95
Angiotensin II
79
more...
Enzyme
ERK
7100
focal adhesion kinase
3403
mitogen-activated protein kinase
2885
protein kinase C
2035
protein kinase
1672
MEK
779
phospholipase C
733
phosphatidylinositol 3-kinase
649
caspase-3
230
thrombin
224
phosphoinositide 3-kinase
217
proteasome
205
luciferase
196
ATPase
191
glutathione S-transferase
162
calcineurin
155
PTPase
154
MAP
150
phospholipase D
149
reverse transcriptase
138
more...
Compound
tyrosine
8276
Dec
2622
DNA
2332
calcium
1870
Clin
1727
ABL
1408
BCR
1376
ATP
1117
serine
929
methionine
872
threonine
816
glucose
672
oxygen
657
acetate
573
Tyrosine
526
MEK
511
cAMP
499
sodium
476
Insulin
474
phosphate
457
more...