Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:6.5.1.2 (DNA ligase)
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Human Gene/Protein
polynucleotide ligase 13.5
bromodomain containing 2 13.5
DNA repair enzyme 13.5
DNA ligase 13.5
homeobox D1 12.5
ZNF433 12.5
DNA ligase I 12.1
polyhomeotic 2 11.9
ALKBH8 11.5
DNA ligase III 11.5
EYA1 protein 11.2
X-ray repair cross-complementing protein 1 11.1
LIG3 11.1
Tyrosyl-DNA phosphodiesterase 1 11.1
DNA ligase 1 10.9
ALKBH2 10.9
Pol lambda 10.8
LIG1 10.7
H2A.X protein 10.7
tyrosyl-DNA phosphodiesterase 1 10.6
Uracil-DNA glycosylase 10.5
putative exonuclease 10.5
FAM129B 10.5
IMPAD1 10.3
XRCC1 protein 10.3
PNK 10.2
CYC4 10.2
TFIP11 10.2
AP lyase 10.1
LIG 10.1
DNA binding peptide 10.0
DNA ligase IV 10.0
SSRP1 protein 9.9
X-ray repair cross-complementing protein 4 9.9
CD3EAP 9.8
ABH2 9.8
beta-polymerase 9.7
class I homeobox 9.7
O6-methylguanine-DNA methyltransferase 9.7
hRad50 9.6
more...
Disease
SCAN1 10.5
Xeroderma 9.0
MYH-associated polyposis 8.4
CRV 8.2
Steroid 21-hydroxylase deficiency 8.1
TGCT 7.6
alcoholic dementia 7.3
Fowlpox 7.2
functioning pituitary adenoma 7.0
Lederer 6.8
Malignant glioma 6.7
brittle hair 6.7
pediatric medulloblastoma 6.7
XPG 6.6
XDP 6.5
RPC 6.4
POH 6.4
xeroderma pigmentosum 6.3
Shope fibroma 6.3
poikiloderma 6.3
Ureteral obstruction 6.2
GAN 6.2
hereditary ataxia 6.1
African swine fever 6.1
metastatic neuroblastoma 6.1
XPD 6.1
XP-A 6.1
BLM 6.0
trichothiodystrophy 6.0
Cockayne syndrome 5.9
HNA 5.8
infectious arthritis 5.7
AHL 5.5
FHA 5.5
vaccinia 5.4
XPF 5.4
metastatic neuroblastoma 5.4
anaplastic astrocytoma 5.3
kidney tumor 5.3
CLN1 5.2
more...
Symptom
skin damage 5.3
hyperoxia 3.5
ataxia 3.5
acute stress 2.3
erythema 1.8
memory loss 1.7
starvation 0.5
constipation 0.2
thinning 0.0
back pain -0.1
functional recovery -0.2
collapse -0.3
hypothermia -0.6
angina -0.9
nausea -1.0
fatigue -2.2
seizures -2.8
anesthesia -3.3
pain -4.5
Drug
Anthramycin 9.2
Adozelesin 8.7
Fotemustine 7.5
Gliadel 7.5
Pyridostigmine bromide 7.3
Truvada 7.1
Domin 7.1
Pyridostigmine bromide 7.0
Sodium acetate 6.8
3-Methyladenine 6.1
Truvada 6.0
-deoxyadenosine 5.9
Arsenic trioxide 5.2
Etoposide 4.9
Orlistat 4.9
Tenofovir 4.8
BLM 4.7
Alanine 4.6
Fludarabine 4.6
Zoledronic acid 4.5
Dihydro 4.5
Imiquimod 4.5
CED 4.3
DNase I 4.3
Dasatinib 4.3
niacin 4.2
Glide 4.2
Riboflavin 3.9
PMPA 3.9
Zoledronic acid 3.9
BoNT/A 3.7
Adenosine triphosphate 3.7
Oxaliplatin 3.7
Monensin 3.6
Mutagen 3.5
AraC 3.4
Asn 3.4
Doxycycline 3.4
ABC 3.4
Fragment 3.3
more...
Enzyme
DNA ligase 13.5
DNA ligase 13.5
DNase V 12.7
DNA 3'-phosphatase 10.7
endonuclease V 10.6
NMN deamidase 10.5
3-methyladenine DNA glycosylase I 10.4
exodeoxyribonuclease 10.3
polynucleotide kinase 10.3
hypoxanthine-DNA glycosylase 10.0
endodeoxyribonuclease 10.0
3'-phosphatase 9.8
Fpg protein 9.7
AP lyase 9.7
dCTPase 9.5
L-serine hydro-lyase 9.5
RNA ligase 9.5
EC 3.6.1.29 9.4
dCMP hydroxymethylase 9.2
Escherichia coli exonuclease III 9.2
endonuclease VII 9.1
AlkA 8.7
ethylbenzene dehydrogenase 8.6
dGTPase 8.4
exonuclease VII 8.3
DNA polymerase 8.2
deoxyribonuclease 8.1
lambda exonuclease 8.1
CMP-KDO synthetase 8.1
exonuclease V 8.1
thymidylate kinase 7.9
SAICAR synthetase 7.9
PRE 7.8
exonuclease I 7.7
coproporphyrinogen III oxidase 7.6
Tpt1 7.5
3'-exonuclease 7.4
dUTPase 7.4
endonuclease 7.3
RNase H 6.9
more...
Compound
Fagaronine chloride 13.5
C21H26ClN3O2 13.5
Bleomycin B2 12.5
C31H24N4 12.5
Acranil 11.2
Decylubiquinone 11.2
C13H8N2O2 10.9
Potassium acetate 10.2
Nemonapride 9.8
deoxyribose-5-phosphate 9.8
2,2,2-trifluoroacetamide 9.6
O6-Methylguanine 8.9
Deoxyinosine 8.8
1,10-decanediol 8.7
HECNU 8.7
7-Methylguanine 8.7
NMN 8.3
Valyl 8.3
Novex 8.2
Methylazoxymethanol 8.1
PCNU 8.0
3-chloropyridine 7.9
Uracil 7.9
Temozolomide 7.8
1,3-dithiolane 7.7
BMN 7.7
3-aminobenzamide 7.5
Phloroglucinol 7.4
S-methylcysteine 7.4
1,5-pentanediol 7.3
ITG 7.3
Trisodium phosphate 7.3
Tuberin 7.3
Phloroglucinol 7.3
Emtricitabine 7.2
3-methoxybenzamide 7.2
XTP 7.2
propionyl-coenzyme A 7.1
adenylate 7.1
dATP 7.1
more...