Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:6.5.1.2 (DNA ligase)
 2,749 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
DNA ligase 1615
DNA repair enzyme 1034
ATP 318
Mol 269
DNA polymerase 249
endonuclease 247
Sep 177
NAD 120
DNA ligase I 119
polynucleotide ligase 99
AMP 98
methylguanine-DNA methyltransferase 88
DNA polymerase beta 75
PARP 73
deoxyribonuclease 72
poly(ADP-ribose) polymerase 69
polypeptide 60
p53 52
hOGG1 50
ADP 48
caspase-3 48
NAD+ 45
proliferating cell nuclear antigen 45
phosphorylating 44
XRCC1 43
thymus 39
OGG1 38
Gen 38
DNA ligase III 38
methyltransferase 37
DNA methyltransferase 37
mer 37
O6-methylguanine-DNA methyltransferase 37
phosphatase 36
NMR 34
photolyase 33
DNA polymerase alpha 33
Pol 32
uracil-DNA glycosylase 32
DNA ligase IV 32
pol 31
fused 30
SDS 29
DNA-dependent protein kinase 28
PARP-1 28
endonuclease III 27
tRNA 27
RNase H 27
topoisomerase I 26
phosphodiesterase 26
histone 26
helicase 25
PARP1 24
APE1 24
superoxide dismutase 24
Pseudomonas 24
AlkB 23
poly (ADP-ribose) polymerase 22
GTP 21
DNA-binding domain 20
XRCC4 19
ATPase 19
Bcl-2 19
BRCA1 18
DNA helicase 17
alkaline phosphatase 17
DNA primase 16
GSH 16
AP lyase 15
LIG4 15
zinc finger 14
DNA gyrase 14
nucleotide pyrophosphatase 14
DNase I 14
cytochrome c 14
3'-5' exonuclease 14
SOD 14
Poly 13
catalase 13
DNA polymerase delta 13
ROS 13
NEIL1 13
ubiquitin 13
XPD 13
DNase 13
H2AX 13
Polymerase 13
Uracil-DNA glycosylase 12
tyrosyl-DNA phosphodiesterase 1 12
ERCC1 12
LIG3 12
FEN1 11
E. coli) 11
ACS 11
DNA-binding protein 11
TdT 11
caspase-8 11
Poly(ADP-ribose) polymerase 11
axonal 11
RNase 11
glutathione peroxidase 11
annexin V 10
caspase-9 10
DNA repair protein 10
LIG1 10
DNA topoisomerase 10
cytokine 10
insulin 10
lymphoid 10
PEG 10
A-T 9
RNA polymerase I 9
twist 9
E.coli 9
ara 9
thymidine kinase 9
single-stranded DNA binding protein 9
LIG 9
replication factor C 9
AAG 9
ATM 9
K-ras 9
Tyrosyl-DNA phosphodiesterase 1 8
ABC 8
APE 8
CTP 8
Rad50 8
cysteine protease 8
unknown function 8
p21 8
C-C 8
Rad51 8
DNA ligase 1 8
flap endonuclease 1 7
CPP32 7
TNF 7
aprataxin 7
AP-1 7
DNA topoisomerase I 7
tumor necrosis factor 7
Rec 7
estrogen receptor 7
threonine 7
interacting protein 7
SNAP 7
thymidylate kinase 7
ATR 7
interferon 7
IIS 7
collagen 7
dUTPase 6
ATF 6
glutathione S-transferase 6
PNK 6
ORF 6
Nei 6
cyclin 6
cytochrome 6
XRCC1 protein 6
VIII 6
more...
Disease
cancer 282
tumor 145
carcinogenesis 60
glioblastoma 39
vaccinia 39
glioma 38
Mycobacterium 31
SDS 29
breast cancer 28
leukemia 28
melanoma 26
tuberculosis 26
xeroderma pigmentosum 20
carcinoma 20
HIV 19
colorectal cancer 17
BLM 17
GSH 16
lung cancer 16
diabetes 15
tumorigenesis 15
ATM 14
cold 14
acute myeloid leukemia 13
glioblastoma multiforme 13
hepatocellular carcinoma 13
plaque 12
immunodeficiency 12
skin cancer 12
Haemophilus 11
African swine fever 11
Alzheimer's disease 10
colon cancer 10
brain tumor 9
MCF 9
gastric cancer 9
neuropathy 9
sarcoma 8
prostate cancer 8
tumor growth 8
metastases 8
neuroblastoma 7
virus infection 7
adenocarcinoma 7
Melanoma 7
tumor progression 7
lymphoma 6
acute lymphoblastic leukemia 6
herpes simplex 6
Cockayne syndrome 6
thalassemia 6
hepatitis C 6
neurological disease 6
ischemia 6
Epstein 6
Leukemia 6
ovarian cancer 6
dementia 6
multiple myeloma 6
anemia 6
atherosclerosis 5
tuberous sclerosis 5
SCID 5
chronic lymphocytic leukemia 5
WRN 5
squamous cell carcinoma 5
non-small cell lung cancer 5
adenoma 5
bends 5
XPD 5
chronic lymphocytic leukemia 5
oral cancer 5
astrocytoma 5
thrombocytopenia 4
obesity 4
stroke 4
herpes 4
renal disease 4
polyposis 4
apraxia 4
chronic myeloid leukemia 4
pulmonary fibrosis 4
bacterial infection 4
Mycoplasma 4
XPG 4
SCAN1 4
B-cell lymphoma 4
hyperglycemia 4
anaplastic astrocytoma 4
rheumatoid arthritis 4
DDP 4
Fanconi 4
malnutrition 4
hypertension 4
African trypanosomiasis 4
B-cell lymphomas 3
Cryptococcus neoformans 3
Huntington's disease 3
neutropenia 3
fits 3
Hippel 3
erythroleukemia 3
lymphopenia 3
infectious diseases 3
brain metastases 3
Burkitt's lymphoma 3
cystic fibrosis 3
amyotrophic lateral sclerosis 3
hepatitis B 3
myocardial infarction 3
RPC 3
T-cell acute lymphoblastic leukemia 3
Infection 3
osteosarcoma 3
APC 3
smallpox 3
cardiovascular disease 3
lung carcinoma 3
type 2 diabetes 3
depression 3
primary tumor 3
cognitive impairment 3
suicide 3
Pituitary 3
Fanconi syndrome 3
solid tumor 3
bladder cancer 3
oligodendroglioma 3
gastritis 3
liver disease 3
cytomegalovirus 3
SMC 3
cerebral ischemia 3
fatty liver 3
CEM 2
ABL 2
systemic lupus erythematosus 2
mole 2
fibrosarcoma 2
Hodgkin's disease 2
mammary tumor 2
hypercholesterolemia 2
folate deficiency 2
metastatic melanoma 2
Age-related macular degeneration 2
multiple endocrine neoplasia 2
lung metastases 2
genetic disorder 2
metastatic neuroblastoma 2
Human immunodeficiency virus type 2
head and neck cancer 2
chronic renal failure 2
autism 2
hematologic malignancies 2
autoimmune disease 2
myeloid leukemia 2
Haemophilia 2
kidney tumor 2
arthritis 2
acute nonlymphocytic leukemia 2
more...
Symptom
ataxia 15
skin damage 5
hyperoxia 5
erythema 4
starvation 3
collapse 2
acute stress 2
nausea 1
constipation 1
seizures 1
angina 1
fatigue 1
thinning 1
memory loss 1
back pain 1
anesthesia 1
hypothermia 1
functional recovery 1
pain 1
Drug
lysine 41
DNase I 14
Dermatol 13
ROS 13
Gel 12
Asn 11
-deoxyadenosine 11
ampicillin 9
ABC 8
Alanine 6
Mutagen 6
niacin 6
Biopolymers 5
NADH 5
caffeine 4
Arsenic trioxide 4
Etoposide 3
lactose 3
BLM 3
Cardiovasc 3
Adriamycin 3
ascorbate 3
Fragment 2
FAD 2
CTX 2
Glutathione 2
MRC 2
TAT 1
AZT 1
9-THC 1
CDP 1
Dihydro 1
Monit 1
CSF 1
Truvada 1
balanced salt solution 1
Imiquimod 1
Sodium acetate 1
VCR 1
CaCl2 1
Zoledronic acid 1
Methylene blue 1
Fludarabine 1
Leaf 1
Anthramycin 1
NBT 1
CaCl2 1
CaCl2 1
CED 1
AZT 1
Fotemustine 1
ZnCl2 1
3-Methyladenine 1
IFN-beta 1
Gliadel 1
Monensin 1
Glide 1
BoNT/A 1
Pyridostigmine bromide 1
Docetaxel 1
ZnCl2 1
ICI 1
Oxaliplatin 1
ALA 1
Angiotensin II 1
AraC 1
Adenosine triphosphate 1
TTC 1
Tenofovir 1
Orlistat 1
G-CSF 1
Pyridostigmine bromide 1
Doxycycline 1
Truvada 1
Zoledronic acid 1
Domin 1
NH3 1
G418 1
Adozelesin 1
Pronase 1
Riboflavin 1
PMPA 1
Vitamin A 1
ADM 1
Dasatinib 1
Nephron 1
Enzyme
DNA ligase 2749
DNA ligase 2746
DNA polymerase 418
endonuclease 247
PARP 99
polynucleotide kinase 71
topoisomerase 57
RNA polymerase 53
topoisomerase 52
phosphodiesterase 50
RNA ligase 42
caspase-3 41
DNA methyltransferase 39
deoxyribonuclease 36
PRE 36
DNase 30
superoxide dismutase 30
protein kinase 28
RNase H 28
Fpg protein 25
ATPase 24
alkaline phosphatase 23
reverse transcriptase 22
RNase 20
endonuclease V 20
RNase 18
catalase 18
AP lyase 17
S1 nuclease 15
trypsin 14
3'-phosphatase 13
ACS 13
endodeoxyribonuclease 12
mitogen-activated protein kinase 12
beta-galactosidase 11
glutathione peroxidase 11
endonuclease VII 10
luciferase 9
alanine aminotransferase 9
glutathione S-transferase 9
thymidine kinase 9
ribonucleotide reductase 8
deoxyribonuclease 8
caspase-8 8
ERK 7
ribonuclease 7
ribonuclease 7
acid phosphatase 7
caspase-9 7
Escherichia coli exonuclease III 6
xanthine oxidase 6
thymidylate kinase 6
3'-exonuclease 6
peroxidase 6
dUTPase 6
focal adhesion kinase 5
lambda exonuclease 5
ribonucleotide reductase 5
deoxycytidine kinase 5
micrococcal nuclease 5
AlkA 4
caspase-1 4
aconitase 4
proteasome 4
protein kinase C 4
thrombin 4
DNA 3'-phosphatase 4
glucose-6-phosphate dehydrogenase 4
exonuclease I 4
DNase V 4
hypoxanthine-guanine phosphoribosyltransferase 4
APC 4
thymidylate synthase 4
chloramphenicol acetyltransferase 4
glyceraldehyde-3-phosphate dehydrogenase 3
coproporphyrinogen III oxidase 3
glyceraldehyde-3-phosphate dehydrogenase 3
TdT 3
hexokinase 3
transcriptase 3
AMPK 3
citrate synthase 3
glyceraldehyde-3-phosphate dehydrogenase 3
thermolysin 3
cdc2 3
firefly luciferase 3
AMP-activated protein kinase 3
chymotrypsin 3
NQO1 3
lactate dehydrogenase 3
demethylase 3
exodeoxyribonuclease 3
beta-lactamase 3
glyceraldehyde-3-phosphate dehydrogenase 3
glyceraldehyde-3-phosphate dehydrogenase 3
Protein 2 3
phospholipase D 3
adenylate kinase 2
adenosine deaminase 2
calcineurin 2
MDR 2
guanylate kinase 2
DNase II 2
acyl-CoA synthetase 2
glucose oxidase 2
exonuclease VII 2
poly(A) polymerase 2
tryptophan synthase 2
PHD 2
cytochrome oxidase 2
ADP-ribosyltransferase 2
NO synthase 2
ADP-ribosyltransferase 2
thymidine phosphorylase 2
dCTPase 2
lysin 2
RNase III 2
carboxypeptidase Y 2
thioredoxin reductase 2
5'-nucleotidase 2
AMPK 2
ornithine decarboxylase 2
deaminase 2
3-methyladenine DNA glycosylase I 2
RNase T1 2
xylanase 2
subtilisin 2
ubiquitin-protein ligase 2
NADPH oxidase 2
NMN deamidase 2
gamma-glutamylcysteine synthetase 2
histone acetyltransferase 2
venom phosphodiesterase 2
adenosine deaminase 2
MEK 2
lysozyme 2
CYP3A4 2
complex I 2
Rex 2
dCMP hydroxymethylase 2
PAT 2
dihydrofolate reductase 2
acyl-CoA synthetase 2
phosphoglycerate kinase 2
ATP synthase 2
histone demethylase 2
exonuclease V 2
p80 1
asparagine synthetase 1
dGTPase 1
dihydropyrimidine dehydrogenase 1
propionyl-CoA carboxylase 1
alcohol dehydrogenase 1
acyl-CoA dehydrogenase 1
pyruvate dehydrogenase 1
fumarase 1
cytidine deaminase 1
lecithin:retinol acyltransferase 1
cystathionine beta-synthase 1
TGT 1
more...
Compound
DNA 2240
ATP 318
Dec 188
phosphate 176
NAD 167
NAD 120
oxygen 104
AMP 102
pyrimidine 90
pyrimidine 90
adenylate 72
lysine 59
hydrogen 54
ADP 52
nicotinamide 49
ADP 48
ADP 48
sodium 46
ADP-ribose 44
salt 39
alanine 39
His 38
Mg2+ 38
water 38
manganese 35
arginine 35
tyrosine 34
cysteine 32
SDS 31
nitric oxide 30
sulfate 28
bromide 28
zinc 27
iron 27
Asp 26
PEG 26
Clin 25
copper 24
dATP 24
GTP 21
EDTA 20
EDTA 20
methyl methanesulfonate 19
Phe 18
H2O2 17
GSH 17
GSH 17
calcium 17
2-oxoglutarate 17
PEG 16
glycerol 16
glucose 16
Temozolomide 16
nitrogen 16
dUTP 16
TTP 15
tryptophan 15
serine 15
3-aminobenzamide 15
dGTP 15
Uracil 15
ethanol 15
silver 14
tryptophan 14
tryptophan 14
tryptophan 14
potassium 13
dCTP 13
threonine 13
pyrene 12
uridine 12
BCNU 11
acetate 11
NH2 11
ammonium 11
ACS 11
urea 11
ACS 11
cobalt 10
nickel 10
aldehyde 10
8-OHdG 10
leucine 10
aldehyde 10
methionine 9
THF 9
NMN 8
methane 8
CTP 8
Gly 8
TNF 7
adenosylmethionine 7
formaldehyde 7
toluene 7
MTT 7
MgCl2 7
Guo 7
HCl 7
ACNU 7
Adenine 7
pyridine 7
Ara-C 6
UTP 6
Tris 6
NTA 6
glutamate 6
retinoic acid 6
DAMP 6
ATF 6
acrylamide 6
formaldehyde 6
Alanine 6
BLM 6
dCMP 6
PPi 6
Tris 6
PMA 6
GMP 6
proline 5
TOF 5
bis(2-chloroethyl) 5
aflatoxin B1 5
Cu(II) 5
bis(2-chloroethyl) 5
bis(2-chloroethyl) 5
DEAE 5
deoxyribose-5-phosphate 5
CAT 5
CAT 5
DMSO 5
phosphorus 5
galactose 5
vinyl 5
MDA 5
CAT 5
Resveratrol 5
MIC 5
NADH 5
NADP 5
Triton X-100 4
DPN 4
XPA 4
asparagine 4
TMP 4
VP-16 4
cadmium 4
N-acetylcysteine 4
Sucrose 4
cAMP 4
Adenine 4
Adriamycin 4
O6-Methylguanine 4
phenol 4
guanidine 4
Cyt 4
formamide 4
XPA 4
dUMP 4
dGMP 4
GSSG 4
more...