Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:6.5.1.2 (
DNA ligase
)
2,749
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We have cloned CDC9, the structural gene for Saccharomyces cerevisiae
DNA ligase
, and investigated its transcriptional regulation both as a function of cell cycle stage and after UV irradiation. The steady-state level of
DNA ligase
mRNA increases at least fourfold in late G1, after the completion of start but before S phase. This high level of CDC9 mRNA then decays with an apparent half-life of ca. 20 min and remains at a low basal level throughout the rest of the cell cycle. The accumulation of CDC9 mRNA in late G1 is dependent upon the completion of start but not the
CDC7
and CDC8 functions. Exposure of cells to UV light elicits an eightfold increase in
DNA ligase
mRNA levels.
...
PMID:Regulation of CDC9, the Saccharomyces cerevisiae gene that encodes DNA ligase. 388 10
