Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:6.5.1.2 (
DNA ligase
)
2,749
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The effect of different vitamin A status on events following DNA damage by hepatocarcinogens was investigated in rats. Formation of single-strand breaks in nuclear DNA induced by aflatoxin B1 and N-nitrosodimethylamine was observed to be more pronounced after vitamin A-deficiency. This enhanced damage was reversed upon vitamin A supplementation. Subsequent to DNA damage, the induction of repair enzymes poly(ADP-ribose) polymerase, DNA polymerase beta and
DNA ligase
was found to be significantly higher in vitamin A-deficient rats.
Vitamin A
supplementation brought down the induction to the levels found in rats maintained on normal diet.
Vitamin A
thus may control carcinogenesis by manipulating molecular events at the initiation stage.
...
PMID:Effect of different vitamin A status on carcinogen-induced DNA damage and repair enzymes in rats. 872 17
