Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:6.5.1.2 (
DNA ligase
)
2,749
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The ubiquitous proto-oncogene protein
DEK
has been found to be associated with chromatin during the entire cell cycle. It changes the topology of DNA in chromatin and protein-free DNA through the introduction of positive supercoils. The sequence and structure specificities of
DEK
-DNA interactions are not completely understood. The binding of
DEK
to DNA is not sequence specific, but we describe here that
DEK
has a clear preference for supercoiled and four-way junction DNA. In the presence of topoisomerase II,
DEK
stimulates intermolecular catenation of circular DNA molecules.
DEK
also increases the probability of intermolecular ligation of linear DNA molecules by
DNA ligase
. These binding properties qualify
DEK
as an architectural protein.
...
PMID:Structure-specific binding of the proto-oncogene protein DEK to DNA. 1462 33
