Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:6.5.1.2 (
DNA ligase
)
2,749
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Poly (ADP-ribose) polymerase (PARP) acts as an essential
DNA repair enzyme
. PARP inhibitors are a novel small molecule targeted drugs based on the principle of 'Synthetic Lethality", which affect the DNA repair process by competitively inhibiting the activity of the PARP enzyme and thereby kill cancer cells. Currently, four PARP inhibitors including olaparib, rucaparib, niraparib, and talazoparib have been approved by FDA for cancer treatment and have achieved great success in the treatment of ovarian cancer, breast cancer, and
pancreatic cancer
etc. This paper provides a general overview of the research progress of PARP inhibitors including the major structure types, structure-activity relationship (SAR), and synthetic routes, with the aim of providing ideas for the discovery and synthesis of novel PARP inhibitors.
...
PMID:A Review on Poly (ADP-ribose) Polymerase (PARP) Inhibitors and Synthetic Methodologies. 3216 5
