Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:6.5.1.1 (
DNA ligase
)
2,749
document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
DNA ligase
1615
DNA repair enzyme
1034
ATP
318
Mol
270
endonuclease
248
DNA polymerase
248
Sep
177
NAD
120
DNA ligase I
119
AMP
100
polynucleotide ligase
99
methylguanine-DNA methyltransferase
88
DNA polymerase beta
75
PARP
73
deoxyribonuclease
72
poly(ADP-ribose) polymerase
69
polypeptide
60
p53
52
hOGG1
50
caspase-3
48
ADP
48
NAD+
45
phosphorylating
44
proliferating cell nuclear antigen
44
XRCC1
43
thymus
39
Gen
38
DNA ligase III
38
OGG1
38
DNA methyltransferase
37
O6-methylguanine-DNA methyltransferase
37
methyltransferase
37
mer
37
phosphatase
36
NMR
34
photolyase
33
DNA polymerase alpha
33
DNA ligase IV
32
Pol
32
uracil-DNA glycosylase
32
pol
31
fused
30
SDS
29
PARP-1
28
DNA-dependent protein kinase
28
tRNA
27
RNase H
27
endonuclease III
27
histone
26
phosphodiesterase
26
topoisomerase I
26
helicase
25
Pseudomonas
24
superoxide dismutase
24
APE1
24
PARP1
24
AlkB
23
poly (ADP-ribose) polymerase
22
GTP
20
DNA-binding domain
20
Bcl-2
19
ATPase
19
XRCC4
19
BRCA1
18
alkaline phosphatase
17
DNA helicase
17
DNA primase
16
GSH
16
LIG4
15
AP lyase
15
3'-5' exonuclease
14
DNA gyrase
14
zinc finger
14
nucleotide pyrophosphatase
14
cytochrome c
14
SOD
14
DNase I
14
NEIL1
13
catalase
13
Poly
13
more...
Disease
cancer
282
tumor
145
carcinogenesis
60
vaccinia
39
glioblastoma
39
glioma
38
Mycobacterium
31
SDS
29
leukemia
28
breast cancer
28
tuberculosis
26
melanoma
26
carcinoma
20
xeroderma pigmentosum
20
HIV
19
colorectal cancer
17
BLM
17
GSH
16
lung cancer
16
tumorigenesis
15
diabetes
15
ATM
14
cold
14
glioblastoma multiforme
13
hepatocellular carcinoma
13
acute myeloid leukemia
13
plaque
12
immunodeficiency
12
skin cancer
12
African swine fever
11
Haemophilus
11
colon cancer
10
Alzheimer's disease
10
gastric cancer
9
MCF
9
brain tumor
9
neuropathy
9
sarcoma
8
metastases
8
prostate cancer
8
tumor growth
8
Melanoma
7
tumor progression
7
virus infection
7
adenocarcinoma
7
neuroblastoma
7
ischemia
6
herpes simplex
6
neurological disease
6
Epstein
6
lymphoma
6
multiple myeloma
6
Cockayne syndrome
6
ovarian cancer
6
thalassemia
6
Leukemia
6
dementia
6
acute lymphoblastic leukemia
6
anemia
6
hepatitis C
6
oral cancer
5
atherosclerosis
5
XPD
5
tuberous sclerosis
5
bends
5
chronic lymphocytic leukemia
5
WRN
5
adenoma
5
SCID
5
squamous cell carcinoma
5
chronic lymphocytic leukemia
5
non-small cell lung cancer
5
astrocytoma
5
pulmonary fibrosis
4
obesity
4
thrombocytopenia
4
hyperglycemia
4
stroke
4
Mycoplasma
4
SCAN1
4
more...
Symptom
ataxia
15
skin damage
5
hyperoxia
5
erythema
4
starvation
3
collapse
2
acute stress
2
nausea
1
constipation
1
seizures
1
angina
1
fatigue
1
thinning
1
memory loss
1
back pain
1
anesthesia
1
hypothermia
1
functional recovery
1
pain
1
Drug
lysine
41
DNase I
14
Dermatol
13
ROS
13
Gel
12
Asn
11
-deoxyadenosine
11
ampicillin
9
ABC
8
Alanine
6
Mutagen
6
niacin
6
Biopolymers
5
NADH
5
caffeine
4
Arsenic trioxide
4
Etoposide
3
lactose
3
BLM
3
Cardiovasc
3
Adriamycin
3
ascorbate
3
Fragment
2
FAD
2
CTX
2
Glutathione
2
MRC
2
TAT
1
AZT
1
9-THC
1
CDP
1
Dihydro
1
Monit
1
CSF
1
Truvada
1
balanced salt solution
1
Imiquimod
1
Sodium acetate
1
VCR
1
CaCl2
1
Zoledronic acid
1
Methylene blue
1
Domin
1
Fludarabine
1
G418
1
Riboflavin
1
CaCl2
1
CaCl2
1
CED
1
Fotemustine
1
ZnCl2
1
3-Methyladenine
1
IFN-beta
1
Gliadel
1
Monensin
1
Glide
1
BoNT/A
1
Pyridostigmine bromide
1
Docetaxel
1
ZnCl2
1
ICI
1
Oxaliplatin
1
ALA
1
Angiotensin II
1
AraC
1
Tenofovir
1
Adenosine triphosphate
1
TTC
1
Pyridostigmine bromide
1
Doxycycline
1
Orlistat
1
G-CSF
1
Truvada
1
Zoledronic acid
1
Leaf
1
NH3
1
Adozelesin
1
Pronase
1
PMPA
1
Vitamin A
1
more...
Enzyme
DNA ligase
2749
DNA ligase
2746
DNA polymerase
418
endonuclease
248
PARP
99
polynucleotide kinase
70
topoisomerase
57
RNA polymerase
53
topoisomerase
52
phosphodiesterase
50
RNA ligase
42
caspase-3
41
DNA methyltransferase
39
PRE
36
deoxyribonuclease
36
superoxide dismutase
30
DNase
30
RNase H
28
protein kinase
27
Fpg protein
25
ATPase
24
alkaline phosphatase
23
reverse transcriptase
22
endonuclease V
20
RNase
20
RNase
18
catalase
18
AP lyase
17
S1 nuclease
15
trypsin
14
3'-phosphatase
13
ACS
13
mitogen-activated protein kinase
12
endodeoxyribonuclease
12
beta-galactosidase
11
glutathione peroxidase
11
endonuclease VII
10
alanine aminotransferase
9
glutathione S-transferase
9
luciferase
9
thymidine kinase
9
caspase-8
8
ribonucleotide reductase
8
deoxyribonuclease
8
caspase-9
7
ribonuclease
7
acid phosphatase
7
ribonuclease
7
ERK
7
peroxidase
6
dUTPase
6
Escherichia coli exonuclease III
6
xanthine oxidase
6
3'-exonuclease
6
thymidylate kinase
6
micrococcal nuclease
5
focal adhesion kinase
5
ribonucleotide reductase
5
lambda exonuclease
5
deoxycytidine kinase
5
DNase V
4
chloramphenicol acetyltransferase
4
DNA 3'-phosphatase
4
APC
4
proteasome
4
caspase-1
4
AlkA
4
exonuclease I
4
thymidylate synthase
4
hypoxanthine-guanine phosphoribosyltransferase
4
glucose-6-phosphate dehydrogenase
4
thrombin
4
protein kinase C
4
aconitase
4
glyceraldehyde-3-phosphate dehydrogenase
3
glyceraldehyde-3-phosphate dehydrogenase
3
demethylase
3
Protein 2
3
beta-lactamase
3
transcriptase
3
more...
Compound
DNA
2241
ATP
318
Dec
188
phosphate
175
NAD
167
NAD
120
AMP
104
oxygen
104
pyrimidine
90
pyrimidine
90
adenylate
72
lysine
59
hydrogen
54
ADP
52
nicotinamide
49
ADP
48
ADP
48
sodium
46
ADP-ribose
44
salt
39
alanine
39
His
38
water
38
Mg2+
38
manganese
35
arginine
35
tyrosine
34
cysteine
32
SDS
31
nitric oxide
30
bromide
28
sulfate
28
zinc
27
iron
27
Asp
26
PEG
26
Clin
25
dATP
24
copper
24
EDTA
20
EDTA
20
GTP
20
methyl methanesulfonate
19
Phe
18
H2O2
17
calcium
17
GSH
17
2-oxoglutarate
17
GSH
17
glycerol
16
glucose
16
nitrogen
16
dUTP
16
PEG
16
Temozolomide
16
TTP
15
dGTP
15
3-aminobenzamide
15
Uracil
15
ethanol
15
tryptophan
15
tryptophan
14
silver
14
serine
14
tryptophan
14
tryptophan
14
threonine
13
potassium
13
dCTP
13
uridine
12
pyrene
12
ACS
11
acetate
11
BCNU
11
urea
11
ACS
11
ammonium
11
NH2
11
aldehyde
10
cobalt
10
more...