Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:6.4.1.2 (acetyl-CoA carboxylase)
 2,876 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Phosphoinositide 3-kinase enhancer (PIKE) is a group of GTPase that belongs to the centaurin superfamily. These proteins have been discovered for more than a decade but our understandings on their functions are still limited. Studies from our research group and others have revealed some of their functions in a cellular context but their roles in organ development or systemic homeostasis just begin to unveil. The generation of PIKE knockout mice thus provides the valuable model to delineate the physiological roles of PIKE. In addition to being a PI3K/Akt enhancer, phenotypic characterization of the PIKE knockout mice demonstrates that the proteins are involved in multiple signaling cascades including Janus kinase (JAK)/ Signal Transducer and Activator of Transcription (STAT), AMP-activated protein kinase (AMPK)/Acetyl-CoA carboxylase (ACC) and insulin receptor (IR)/Akt. In this article, we will review the current findings from the PIKE knockout mice studies and will discuss how these in vivo observations lead to the identifications of novel signaling cascades regulated by PIKE.
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PMID:What we have learnt about PIKE from the knockout mice. 2200 35

Janus kinase (JAK) is a family of non-receptor tyrosine kinases that participate in transducing cytokine signals from the external environment to the nucleus in various biological processes. Currently, information about their genes structure and evolutionary history has been extensively studied in mammals as well as in several fish species. By contrast, limited reports have addressed potential role of diverse JAK in signaling responses to leptin in fish. In this study, we identified and characterized five JAK members of Synechogobius hasta. Compared to mammals, more members of the JAK family were found in S. hasta, which provided evidence that the JAK family members had arisen by the whole genome duplications during vertebrate evolution. For protein structure, all of these members possessed similar domains compared with those of mammals. Their mRNAs were expressed in a wide range of tissues, but at the different levels. Incubation in vitro of freshly isolated hepatocytes of S. hasta with different concentrations of recombinant human leptin decreased the intracellular triglyceride content and lipogenic genes expression, and increased mRNA expression of several JAK and lipolytic genes. AG490, a specific inhibitor of JAK, reversed leptin-induced effects on TG content and JAK2a, JAK2b, hormone-sensitive lipase (HSL2) and acetyl-CoA carboxylase (ACCa), indicating that the JAK2a/b may have mediated the actions of leptin on lipid metabolism at transcriptional level.
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PMID:JAK family members: Molecular cloning, expression profiles and their roles in leptin influencing lipid metabolism in Synechogobius hasta. 2778 45