Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:6.4.1.2 (acetyl-CoA carboxylase)
 2,876 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The zonal distribution of cytosolic acetyl-CoA carboxylase, mitochondrial 3-hydroxyacyl-CoA dehydrogenase and 3-hydroxybutyrate dehydrogenase was studied in microdissected liver tissue. In fed male and female rats the activity of the lipogenic enzyme acetyl-CoA carboxylase was 1.6-times higher in the perivenous than in the periportal zone of the liver acinus. 3-Hydroxybutyrate dehydrogenase, which is involved in the formation of the ketone body, 3-hydroxybutyrate, exhibited a similar distribution pattern with a 1.5-1.8-times higher activity in the perivenous than in the periportal zone. In contrast, the activity of 3-hydroxyacyl-CoA dehydrogenase, the third enzyme in beta-oxidation, was about equally distributed between the periportal and the perivenous zone of the liver acinus. The results indicate a predominance of lipogenesis in the perivenous, mainly glycolytic zone of the liver acinus. Furthermore, these data support the hypothesis that beta-oxidation supplies energy for basic and anabolic processes like gluconeogenesis in the periportal zone, while it provides acetyl-CoA for ketogenesis besides energy for basic needs in the perivenous zone.
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PMID:Distribution of enzymes of fatty acid and ketone body metabolism in periportal and perivenous rat-liver tissue. 613 5

To assess the lipid metabolising potential of testicular germ cells undergoing meiosis, spermatocytes and spermatids were isolated from adult rat testis and purified by centrifugal elutriation followed by density gradient centrifugation. Seven key enzymes of lipid metabolism (namely beta-hydroxybutyrate dehydrogenase, carnitine acetyl transferase, ATP citrate lyase, hydroxyacyl-CoA dehydrogenase, glycerol 3-phosphate dehydrogenase, acetyl-CoA carboxylase and long chain acyl-CoA synthetase) were assayed in cell homogenates. The results indicated that germ cells possess the key enzymes for de novo synthesis and oxidation of fatty acids. The significant increase in activities of anabolic enzymes and decrease in activities of catabolic enzymes in post-meiotic germ cells indicated a shift in lipid metabolism towards fatty acid synthesis during meiosis. Long chain acyl-CoA synthetase activity was not detected in the two cell types. The study indicates a major reorganization of fatty acid turnover during meiosis with equilibrium shifting in favour of synthesis.
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PMID:Lipid metabolising enzymes in isolated rat testicular germ cells and changes associated with meiosis. 983 44