Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:6.4.1.2 (
acetyl-CoA carboxylase
)
2,876
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
It has been shown that lipogenic enzymes, such as fatty acid synthase (FAS) and
acetyl-CoA carboxylase
(
ACC
), are highly expressed in the rodent brain during the early neonatal period and decline thereafter. However, cellular localization of these enzymes is unknown. Presently, we examined developmental changes in the levels and cellular localization of FAS and
ACC
, and their putative regulators, sterol-regulatory element-binding protein (SREBP)-1 and AMP-activated protein kinase (AMPK) in the mouse brain. Levels of these proteins including phosphorylated forms of
ACC
and AMPK decreased between postnatal day 4 (P4) and
P19
. Immunohistochemical studies indicated that FAS,
ACC
, AMPK, and SREBP-1 were expressed in neurons at P7, while FAS was found mostly in cells of oligodendrocyte lineage at
P19
. These studies suggest that neurons in the early neonatal brain are involved in do novo fatty acid synthesis.
...
PMID:Developmental profiles of lipogenic enzymes and their regulators in the neonatal mouse brain. 1941 21
