Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:6.4.1.1 (pyruvate carboxylase)
 1,516 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
CGI-49 14.4
pyruvate carboxylase 14.4
pyruvate carboxylase, mitochondrial 13.9
SDHC protein 13.4
Pyruvate carboxylase 13.4
succinyl-CoA:3-ketoacid-CoA transferase 12.8
ASCI 12.5
ATP5J2 12.0
TOP2 beta 12.0
propionyl-CoA carboxylase 11.7
acyl-CoA dehydrogenase 9 11.6
biotin carboxylase 11.5
holocarboxylase synthetase 11.5
PEPCK-M 11.5
L-alanine:glyoxylate aminotransferase 11.2
PCK2 11.1
BPC1 11.0
ATPase homolog 11.0
MCCC2 10.8
phosphoenolpyruvate carboxykinase 10.7
CA V 10.7
carboxylating 10.7
ACSS3 10.7
fructose-1,6-bisphosphatase 1 10.6
pccA 10.6
Max-like protein X 10.6
PEPCK-C 10.5
mitochondrial citrate transport protein 10.5
ODPA 10.4
Malic enzyme 10.4
Holocarboxylase synthetase 10.4
phosphoenolpyruvate carboxykinase 2 10.4
carnitine palmitoyltransferase 1A 10.3
PCK1 10.2
D-fructose-1,6-bisphosphate 1-phosphohydrolase 10.2
phosphoenolpyruvate carboxykinase 1 10.2
PDC2 10.1
TALH 10.0
LYS5 10.0
ME3 10.0
phosphoenolpyruvate carboxylase 9.9
MAEA 9.9
Phosphoserine phosphatase 9.8
ME4 9.8
glycerol-3-phosphate dehydrogenase 1 9.8
biotinidase 9.8
fructose 1,6-bisphosphatase 9.8
pyruvate dehydrogenase 9.8
aconitate hydratase 9.8
carbamoylphosphate synthetase I 9.8
steroid dehydrogenase-like protein 9.7
sodium-dependent multivitamin transporter 9.7
CA5 9.6
3-hydroxybutyrate dehydrogenase 9.6
RagD 9.6
CS-3 9.6
SLC25A1 9.6
ubiquinol-cytochrome c reductase complex 9.6
Nicotinamide nucleotide transhydrogenase 9.5
S3-12 9.5
MCCC1 9.5
Fructose 1,6-bisphosphatase 9.5
5-methyltetrahydrofolate-homocysteine methyltransferase 9.5
fumarase 9.4
nicotinic acid phosphoribosyltransferase 9.4
OPA3 9.3
IST1 9.3
Phosphoglycerate dehydrogenase 9.3
acetoacetyl-CoA synthetase 9.2
PEPCK 9.2
phosphoglyceromutase 9.2
MUL 9.1
arylsulfatase E 9.1
PSPH 9.1
decarboxylating 9.1
hepatocyte nuclear factor 1 alpha 9.1
glucose-6-phosphatase 9.0
SP-22 9.0
PGC1A 9.0
2-oxoglutarate dehydrogenase 9.0
more...
Disease
Multiple carboxylase deficiency 12.6
Avian reticuloendotheliosis 12.0
Biotin deficiency 11.8
PC deficiency 11.3
Organic acidemias 11.0
hyperlysinemia 10.9
Ketonemia 10.9
MILS 10.3
MGA3 10.1
Goodall 8.8
encephalomyelopathy 8.7
Hers 8.7
Carcinoma ex pleomorphic adenoma 8.4
disorders of amino acid metabolism 8.1
Leigh syndrome 8.0
Alpers 7.9
PDH deficiency 7.9
Biotinidase deficiency 7.7
citrullinemia 7.7
Ondine's curse 7.6
marijuana abuse 7.6
lactic acidosis 7.6
propionic acidemia 7.6
Ondine's curse 7.6
Reye's syndrome 7.2
Reye 6.9
methylmalonic acidemia 6.9
glutaric aciduria 6.9
kidney hypertrophy 6.7
hepatic porphyria 6.4
Barth syndrome 6.4
GSD I 6.3
mitochondrial encephalomyopathy 6.3
RDP 6.1
ketosis 6.0
Forbes 5.9
BCH 5.8
lipidosis 5.8
Sutton 5.8
Wernicke's encephalopathy 5.7
PDC 5.7
Benson 5.7
FDH 5.7
marasmus 5.6
insulinoma 5.5
clonorchiasis 5.5
MELAS 5.5
porphyria 5.4
renal tubular acidosis 5.4
profound mental retardation 5.3
mitochondrial myopathy 5.2
laryngospasm 5.2
hypoglycemia 5.2
MELAS 5.2
hyperphenylalaninemia 5.1
hypophosphatasia 5.1
AIP 5.1
MCD 5.1
cystinuria 5.1
GSD 5.1
Korsakoff's syndrome 5.0
AIP 5.0
Kearns-Sayre syndrome 5.0
reticuloendotheliosis 5.0
fatty liver 5.0
GSD 4.9
Acute liver failure 4.9
hepatic encephalopathy 4.9
dysphasia 4.8
PMS 4.7
DWI 4.7
PCT 4.7
kwashiorkor 4.7
parakeratosis 4.6
porphyria cutanea tarda 4.6
magnesium deficiency 4.6
acute intermittent porphyria 4.6
HCA 4.5
quadriparesis 4.5
maple syrup urine disease 4.4
more...
Symptom
Tissue anoxia 12.0
Spots 5.5
ketonuria 5.2
hypotonia 5.2
lethargy 4.7
consciousness disturbance 4.7
starvation 4.1
incoordination 3.6
tachypnea 3.0
exhaustion 2.9
cerebellar ataxia 2.5
ataxia 2.4
hemiplegia 2.4
dystonia 2.3
myoclonus 2.3
vomiting 2.0
hunger 1.9
hepatomegaly 1.9
spasticity 1.7
seizures 1.7
anorexia 1.6
hypercapnia 1.4
hypothermia 1.3
constipation 1.0
Ill 0.9
agitation 0.8
acidity 0.5
tremor 0.2
respiratory distress 0.1
anesthesia -0.4
dyspnea -0.4
collapse -0.4
abdominal pain -0.6
fatigue -1.3
Drug
Formycin 10.6
p-Chlorophenyl 10.5
Posilac 10.0
Aspartic Acid 9.2
citric acid 7.1
Corn oil 7.1
Pentostam 7.0
Tween 40 6.8
CDX 6.4
Citric acid 6.4
Bezafibrate 6.2
Sodium valproate 6.0
Colombo 6.0
Glucagon 5.9
NADH 5.9
CDX 5.9
Arsenic trioxide 5.6
Glycerol 5.5
Alanine 5.5
Glutamic acid 5.4
Clofibrate 5.2
Fructose 5.0
DMI 4.9
Monensin 4.5
Galactose 4.3
Aloe 4.1
Vitamin B 4.1
Honey 4.0
lysine 4.0
lactose 3.9
FAD 3.5
Ethanol 3.4
G418 3.2
CDP 3.2
pyridoxal phosphate 3.1
Nitric Oxide 3.0
ALA 2.9
MRC 2.6
Gel 2.5
PCB 2.3
CSF 2.2
ROS 2.1
Asn 1.8
NH3 1.6
THF 1.4
ascorbate 0.9
MAP 0.4
vitamin E 0.3
caffeine -0.0
Leaf -0.0
Dermatol -3.6
Enzyme
pyruvate carboxylase 14.4
EC 4.1.1.40 13.4
methylcrotonyl-CoA carboxylase 12.9
acylpyruvate hydrolase 12.4
geranoyl-CoA carboxylase 12.4
CimA 12.0
biotin carboxylase 11.8
propionyl-CoA carboxylase 11.6
propionyl-CoA carboxylase 11.6
glycerophosphate phosphatase 11.6
transcarboxylase 11.4
diaminopimelate dehydrogenase 10.9
oxaloacetate decarboxylase 10.8
phosphoenolpyruvate carboxykinase 10.5
phosphoenolpyruvate carboxykinase 10.5
phosphoenolpyruvate carboxykinase 10.4
fructose 1,6-bisphosphatase 10.1
phosphoenolpyruvate carboxylase 10.0
pyruvate dehydrogenase 10.0
pyruvate dehydrogenase 10.0
EC 1.1.1.82 10.0
6-phosphogluconate dehydratase 10.0
phosphoenolpyruvate synthase 9.9
EC 1.1.1.38 9.9
biotinidase 9.8
alcohol acetyltransferase 9.7
pyruvate dehydrogenase 9.6
L-asparagine synthetase 9.6
EC 1.1.1.40 9.5
2-oxoglutarate decarboxylase 9.5
methylmalonate-semialdehyde dehydrogenase 9.4
citramalate synthase 9.3
citrate lyase 9.2
nicotinic acid phosphoribosyltransferase 9.2
diaminopimelate decarboxylase 9.1
glucose-6-phosphatase 9.1
isocitrate lyase 9.1
PPDK 9.0
acetoacetyl-CoA synthetase 9.0
citrate cleavage enzyme 9.0
oxoglutarate dehydrogenase 9.0
EC 1.1.1.39 9.0
fumarase 9.0
2-keto-3-deoxy-6-phosphogluconate aldolase 8.9
malate synthase 8.9
desulfinase 8.9
pyruvate:ferredoxin oxidoreductase 8.8
ribulose 5-phosphate 3-epimerase 8.8
acetyl-CoA carboxylase 8.8
EC 2.4.1.11 8.8
dihydrodipicolinate reductase 8.8
GapB 8.8
alpha-ketoglutarate dehydrogenase 8.7
desulfhydrase 8.7
sarcosine dehydrogenase 8.6
acetyl-CoA hydrolase 8.6
aspartokinase 8.5
branched-chain aminotransferase 8.5
pyruvate kinase 8.5
N-acetylglutamate kinase 8.5
pyruvate decarboxylase 8.4
malate dehydrogenase 8.4
citrate synthase 8.4
isocitrate dehydrogenase 8.3
PDH 8.3
acetate kinase 8.3
10-formyltetrahydrofolate dehydrogenase 8.3
isocitrate dehydrogenase 8.2
dihydrolipoamide succinyltransferase 8.2
glutamic dehydrogenase 8.1
lipoate acetyltransferase 8.1
beta-hydroxybutyrate dehydrogenase 8.1
CMP kinase 8.0
benzoylformate decarboxylase 8.0
pyruvate dehydrogenase phosphatase 7.9
acetyl-CoA synthetase 7.9
aconitase 7.8
HMG-CoA synthase 7.8
phosphofructokinase 7.8
phosphoglyceromutase 7.8
more...
Compound
6-aminotryptophan 14.4
Chlorothricin 13.4
2-hydroxyethyl carbamate 12.0
Decanoylcarnitine 11.8
PYC 11.5
O-acetylcarnitine 11.2
Fluoropyruvate 11.2
Butylmalonate 11.0
N-formimino-l-glutamate 11.0
3-methylcrotonyl-CoA 10.9
2,4-pyrimidinediamine 10.7
Oxamate 10.3
3-hydroxyisovaleric acid 10.1
Phenylpyruvate 10.0
oxalacetate 9.9
beta-methylcrotonic acid 9.8
dimethyl malate 9.8
propionyl-coenzyme A 9.5
Ethoxzolamide 9.5
TPTA 9.3
acetyl-CoA 9.2
benzoylformic acid 9.0
Metribuzin 9.0
dimethyl succinate 8.9
Nialamide 8.8
2-Oxoglutarate 8.8
2-oxobutyrate 8.7
Biotin 8.7
Pyruvate 8.6
2-oxobutyrate 8.4
Amytal 8.3
isocitrate 8.2
Acetyl phosphate 8.2
malic acid 8.1
malic acid 8.1
malic acid 8.1
malic acid 8.1
Pyruvate kinase 7.9
1-Methyl-4-phenylpyridinium 7.9
2-oxoglutarate 7.9
Ponceau S 7.8
Malate 7.8
PEP 7.8
phenylacetic acid 7.7
phenylacetic acid 7.7
phenylacetic acid 7.7
PDH 7.7
erythrose-4-phosphate 7.7
phenylacetic acid 7.7
Glyoxylate 7.6
2-oxoadipate 7.6
glutaryl-CoA 7.5
phenylarsonic acid 7.5
CoA 7.5
pentose 7.4
pentose 7.4
Flux 7.4
pentose 7.4
6-phosphogluconate 7.4
TCA 7.4
sedoheptulose 7-phosphate 7.3
pentose 7.3
acetoacetyl-CoA 7.3
DTB 7.3
DTB 7.3
Selenate 7.3
Fumarate 7.2
DTB 7.2
Biocytin 7.2
phenyl acetate 7.1
MAL 7.1
succinic acid 7.1
succinic acid 7.1
succinic acid 7.1
succinic acid 7.1
2-phosphoglycerate 7.1
4-pentenoic acid 7.1
IDP 7.1
glutamine 7.1
sulfamic acid 7.0
more...