Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:6.4.1.1 (pyruvate carboxylase)
 1,516 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
pyruvate carboxylase 1416
phosphoenolpyruvate carboxykinase 239
ATP 191
insulin 179
pyruvate dehydrogenase 171
Pyruvate carboxylase 166
CO2 102
Sep 92
pyruvate kinase 87
NMR 82
glucose-6-phosphatase 77
ADP 74
malate dehydrogenase 71
phosphoenolpyruvate carboxylase 70
TCA 67
citrate synthase 66
NADH 63
glucagon 62
Mol 61
acetyl-CoA carboxylase 59
lactate dehydrogenase 56
NAD 49
propionyl-CoA carboxylase 48
isocitrate dehydrogenase 46
glutamine synthetase 45
glutamate dehydrogenase 42
biotin carboxylase 40
NADPH 40
NADP 36
GABA 35
aspartate aminotransferase 35
pyruvate dehydrogenase complex 34
phosphatase 34
phosphofructokinase 33
AMP 31
polypeptide 28
Pseudomonas 26
hexokinase 26
fumarase 25
glucokinase 23
alanine aminotransferase 22
NAD+ 21
INS-1 18
biotinidase 17
PEP 17
holocarboxylase synthetase 17
Gen 17
carbonic anhydrase 17
PEPCK 16
fructose-1,6-bisphosphatase 16
fatty acid synthase 15
fructose 1,6-bisphosphatase 15
carboxylating 15
glucose transporter 14
glucose-6-phosphate dehydrogenase 14
superoxide dismutase 14
aconitase 14
threonine 14
ASCI 13
decarboxylating 12
glutaminase 12
ATPase 12
ACL 12
2-oxoglutarate dehydrogenase 12
PCK1 11
catalase 11
long chain 11
NEFA 11
C18 11
PDH 11
cytochrome c oxidase 10
peroxisome proliferator-activated receptor 10
SDS 10
alpha-ketoglutarate dehydrogenase 10
Net 10
alkaline phosphatase 9
Malic enzyme 9
epididymal 9
Pyruvate dehydrogenase 9
G6Pase 9
more...
Disease
diabetes 53
lactic acidosis 39
hypoglycemia 38
cancer 33
type 2 diabetes 29
tumor 28
hyperglycemia 25
fatty liver 21
PC deficiency 20
Leigh syndrome 18
obesity 15
depression 13
Biotin deficiency 11
SDS 10
breast cancer 10
encephalopathy 10
cold 10
Mycobacterium 9
epilepsy 8
insulinoma 8
hepatocellular carcinoma 7
ischemia 6
glioma 6
hepatic encephalopathy 6
Reye's syndrome 6
ketosis 6
glucose intolerance 6
coma 5
stroke 4
propionic acidemia 4
mental retardation 4
methylmalonic acidemia 4
metabolic disorder 4
renal tubular acidosis 4
Alzheimer's disease 4
mole 4
mental retardation 4
mole 4
GSH 4
MCF 4
dehydration 4
tuberculosis 4
fits 4
sepsis 4
malnutrition 4
pheochromocytoma 4
hyperthyroidism 3
sepsis 3
status epilepticus 3
virus infection 3
citrullinemia 3
porphyria 3
hyperlysinemia 3
glioblastoma 3
lung cancer 3
hyperlipidemia 3
tumorigenesis 3
brain edema 3
Huntington's disease 3
tumor growth 3
influenza 3
non-small cell lung cancer 3
PCC 3
melanoma 3
Parkinson's disease 3
astrocytoma 3
developmental delay 3
type 1 diabetes 3
Multiple carboxylase deficiency 2
heart failure 2
liver disease 2
Wernicke's encephalopathy 2
metabolic syndrome 2
myopathy 2
glutaric aciduria 2
adenocarcinoma 2
encephalomyelopathy 2
MGA3 2
West 2
iron deficiency 2
more...
Symptom
starvation 20
seizures 12
hypotonia 10
lethargy 7
vomiting 6
exhaustion 5
anesthesia 4
ataxia 4
dystonia 2
hypothermia 2
anorexia 2
abdominal pain 1
cerebellar ataxia 1
fatigue 1
consciousness disturbance 1
Ill 1
hunger 1
Spots 1
hypercapnia 1
spasticity 1
respiratory distress 1
tachypnea 1
myoclonus 1
constipation 1
dyspnea 1
agitation 1
Tissue anoxia 1
hepatomegaly 1
acidity 1
collapse 1
ketonuria 1
incoordination 1
hemiplegia 1
tremor 1
Drug
citric acid 66
NADH 64
lysine 44
lactose 12
Glucagon 11
CSF 7
Alanine 6
Glycerol 5
Ethanol 5
Gel 4
ROS 4
Fructose 3
DMI 3
Arsenic trioxide 3
FAD 3
ascorbate 2
Asn 2
Citric acid 2
Posilac 2
vitamin E 1
Formycin 1
ALA 1
Leaf 1
Aloe 1
pyridoxal phosphate 1
Colombo 1
CDX 1
Tween 40 1
Dermatol 1
Galactose 1
THF 1
G418 1
Pentostam 1
Corn oil 1
Honey 1
CDP 1
Vitamin B 1
Sodium valproate 1
PCB 1
caffeine 1
MRC 1
MAP 1
Glutamic acid 1
p-Chlorophenyl 1
Aspartic Acid 1
Monensin 1
Nitric Oxide 1
Clofibrate 1
Bezafibrate 1
CDX 1
NH3 1
Enzyme
pyruvate carboxylase 1516
phosphoenolpyruvate carboxykinase 296
phosphoenolpyruvate carboxykinase 296
phosphoenolpyruvate carboxykinase 296
pyruvate dehydrogenase 206
pyruvate dehydrogenase 171
pyruvate dehydrogenase 171
pyruvate kinase 90
phosphoenolpyruvate carboxylase 84
glucose-6-phosphatase 81
malate dehydrogenase 75
citrate synthase 71
acetyl-CoA carboxylase 61
lactate dehydrogenase 59
propionyl-CoA carboxylase 52
propionyl-CoA carboxylase 51
isocitrate dehydrogenase 50
isocitrate dehydrogenase 48
glutamine synthetase 45
glutamate dehydrogenase 43
glutamate dehydrogenase 43
glutamate dehydrogenase 43
fructose 1,6-bisphosphatase 42
phosphofructokinase 40
biotin carboxylase 40
aspartate aminotransferase 38
methylcrotonyl-CoA carboxylase 33
hexokinase 27
fumarase 27
alanine aminotransferase 26
alpha-ketoglutarate dehydrogenase 26
isocitrate lyase 25
succinate dehydrogenase 25
glucokinase 24
glucose-6-phosphate dehydrogenase 23
aconitase 19
biotinidase 17
glyceraldehyde-3-phosphate dehydrogenase 16
luciferase 15
transcarboxylase 14
carbonic anhydrase 14
oxaloacetate decarboxylase 14
superoxide dismutase 14
pyruvate decarboxylase 14
glutaminase 13
malate synthase 12
ATP synthase 12
ATPase 12
catalase 11
ACE 11
protein kinase 11
PDH 10
AMP-activated protein kinase 10
rubisco 10
glyceraldehyde-3-phosphate dehydrogenase 10
alkaline phosphatase 9
ornithine transcarbamylase 9
glycerol-3-phosphate dehydrogenase 9
alcohol dehydrogenase 9
glycerol-3-phosphate dehydrogenase 9
CPS 9
6-phosphogluconate dehydrogenase 9
6-phosphogluconate dehydrogenase 9
ACS 8
glyceraldehyde-3-phosphate dehydrogenase 8
glyceraldehyde-3-phosphate dehydrogenase 8
citrate lyase 8
acyl-CoA synthetase 7
EC 1.1.1.40 7
aspartokinase 7
phosphoglycerate kinase 7
acetate kinase 7
CPT 7
diaphorase 7
glyceraldehyde-3-phosphate dehydrogenase 7
PDK1 7
cytochrome oxidase 7
succinic dehydrogenase 7
diaphorase 6
transhydrogenase 6
more...
Compound
glucose 632
glutamate 229
ATP 191
glutamine 170
acetyl-CoA 152
alanine 152
phosphate 135
CoA 130
CO2 122
Dec 96
acetate 96
glycerol 83
2-oxoglutarate 82
ADP 75
ADP 74
ADP 74
TCA 70
NAD 68
NADH 64
DNA 54
oxygen 53
pentose 52
pentose 51
pentose 51
pentose 51
NADP 49
NAD 49
urea 48
lysine 46
nitrogen 44
NADPH 40
NADPH 40
ethanol 38
Pyruvate 35
AMP 35
GABA 35
GABA 35
oxalacetate 34
sodium 33
Biotin 33
ammonia 32
malic acid 31
water 29
methionine 27
Clin 26
serine 26
ammonium 25
Glutamate 25
malic acid 25
carbonate 24
malic acid 24
isocitrate 24
PEP 24
malic acid 24
calcium 21
succinic acid 21
threonine 20
Mg2+ 20
Lactate 20
Asp 18
arginine 18
acetic acid 17
manganese 17
Insulin 16
proline 16
succinic acid 15
galactose 15
succinic acid 15
succinic acid 15
sulfate 15
succinic acid 15
leucine 15
His 14
cAMP 14
Flux 14
aspartic acid 14
HCO 13
glucose-6-phosphate 13
glutamic acid 12
asparagine 12
more...