Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:6.4.1.1 (pyruvate carboxylase)
 1,516 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
pyruvate carboxylase 1416
phosphoenolpyruvate carboxykinase 239
ATP 191
insulin 179
pyruvate dehydrogenase 171
Pyruvate carboxylase 166
CO2 102
Sep 92
pyruvate kinase 87
NMR 82
glucose-6-phosphatase 77
ADP 74
malate dehydrogenase 71
phosphoenolpyruvate carboxylase 70
TCA 67
citrate synthase 66
NADH 63
glucagon 62
Mol 61
acetyl-CoA carboxylase 59
lactate dehydrogenase 56
NAD 49
propionyl-CoA carboxylase 48
isocitrate dehydrogenase 46
glutamine synthetase 45
glutamate dehydrogenase 42
NADPH 40
biotin carboxylase 40
NADP 36
aspartate aminotransferase 35
GABA 35
pyruvate dehydrogenase complex 34
phosphatase 34
phosphofructokinase 33
AMP 31
polypeptide 28
Pseudomonas 26
hexokinase 26
fumarase 25
glucokinase 23
alanine aminotransferase 22
NAD+ 21
INS-1 18
biotinidase 17
carbonic anhydrase 17
PEP 17
holocarboxylase synthetase 17
Gen 17
fructose-1,6-bisphosphatase 16
PEPCK 16
carboxylating 15
fructose 1,6-bisphosphatase 15
fatty acid synthase 15
superoxide dismutase 14
aconitase 14
glucose-6-phosphate dehydrogenase 14
threonine 14
glucose transporter 14
ASCI 13
ACL 12
decarboxylating 12
2-oxoglutarate dehydrogenase 12
ATPase 12
glutaminase 12
catalase 11
C18 11
PDH 11
PCK1 11
long chain 11
NEFA 11
alpha-ketoglutarate dehydrogenase 10
SDS 10
cytochrome c oxidase 10
peroxisome proliferator-activated receptor 10
Net 10
Pyruvate dehydrogenase 9
G6Pase 9
Malic enzyme 9
alkaline phosphatase 9
6-phosphogluconate dehydrogenase 9
epididymal 9
casein 9
GTP 8
alcohol dehydrogenase 8
glyceraldehyde 3-phosphate dehydrogenase 8
C-1 8
CA V 8
glycolytic enzyme 8
ATP citrate lyase 8
CSF 7
PEPCK-C 7
glyceraldehyde-3-phosphate dehydrogenase 7
insulin receptor 7
PCK2 7
NADP+ 7
ornithine transcarbamylase 7
dimeric 6
acyl-CoA synthetase 6
argininosuccinate synthetase 6
acetyl-CoA synthetase 6
6-phosphofructokinase 6
carnitine palmitoyltransferase 6
CA II 6
carbamoylphosphate synthetase 6
carnitine palmitoyltransferase 1A 6
AMP-activated protein kinase 6
albumin 6
oxoglutarate 6
Holocarboxylase synthetase 6
housekeeping 5
phosphoglycerate kinase 5
She 5
PGC 5
lipoamide dehydrogenase 5
Carbonic anhydrase 5
ACC 5
reductase 5
endoplasmic reticulum 5
histone 5
asymmetrical 5
cytochrome c 5
Malate dehydrogenase 5
Pyruvate kinase 5
ATP synthase 5
A-I 5
microsomal 5
leptin 5
aconitate hydratase 5
pyruvate dehydrogenase kinase 5
acyl-CoA dehydrogenase 5
3-hydroxybutyrate dehydrogenase 5
peroxidase 5
glucose dehydrogenase 4
peroxisome proliferator-activated receptor gamma 4
insulin-like growth factor-I 4
USF1 4
serum albumin 4
ACC1 4
AMPK 4
adenylate cyclase 4
Met 4
Isocitrate dehydrogenase 4
NIDDM 4
penumbra 4
phosphoenolpyruvate carboxykinase 1 4
glycogen synthase 4
enolase 4
E1 alpha 4
transketolase 4
PPAR 4
GSH 4
lipoprotein lipase 4
HMG-CoA synthase 4
adenylate kinase 4
ROS 4
N-acetylaspartate 4
PEPCK-M 4
aldehyde dehydrogenase 4
homeobox 4
haptoglobin 4
more...
Disease
diabetes 53
lactic acidosis 39
hypoglycemia 38
cancer 33
type 2 diabetes 29
tumor 28
hyperglycemia 25
fatty liver 21
PC deficiency 20
Leigh syndrome 18
obesity 15
depression 13
Biotin deficiency 11
breast cancer 10
encephalopathy 10
cold 10
SDS 10
Mycobacterium 9
epilepsy 8
insulinoma 8
hepatocellular carcinoma 7
ischemia 6
glioma 6
glucose intolerance 6
hepatic encephalopathy 6
ketosis 6
Reye's syndrome 6
coma 5
tuberculosis 4
fits 4
methylmalonic acidemia 4
stroke 4
mental retardation 4
metabolic disorder 4
MCF 4
malnutrition 4
sepsis 4
mole 4
Alzheimer's disease 4
mole 4
pheochromocytoma 4
GSH 4
mental retardation 4
dehydration 4
propionic acidemia 4
renal tubular acidosis 4
developmental delay 3
influenza 3
hyperlysinemia 3
hyperthyroidism 3
tumor growth 3
tumorigenesis 3
glioblastoma 3
virus infection 3
melanoma 3
sepsis 3
lung cancer 3
hyperlipidemia 3
type 1 diabetes 3
astrocytoma 3
brain edema 3
PCC 3
Huntington's disease 3
Parkinson's disease 3
status epilepticus 3
non-small cell lung cancer 3
porphyria 3
citrullinemia 3
Multiple carboxylase deficiency 2
myopathy 2
Syndrome 2
mitochondrial encephalomyopathy 2
liver disease 2
mitochondrial myopathy 2
failure to thrive 2
adenocarcinoma 2
Rett syndrome 2
encephalomyelopathy 2
iron deficiency 2
colon cancer 2
West 2
ovarian cancer 2
lipidosis 2
Brown 2
genetic disorder 2
respiratory failure 2
carcinoma 2
SEM 2
PDC 2
Benson 2
Alpers 2
neuroblastoma 2
paraganglioma 2
MGA3 2
BCH 2
heart failure 2
Wernicke's encephalopathy 2
porphyria cutanea tarda 2
brain atrophy 2
metabolic syndrome 2
glutaric aciduria 2
renal cell carcinoma 2
uterus 1
Sutton 1
alkalosis 1
pneumonia 1
Schistosoma mansoni 1
lymphoma 1
MELAS 1
bronchopneumonia 1
kidney hypertrophy 1
brucellosis 1
neurological disease 1
dyslipidemia 1
cystic fibrosis 1
PCA 1
MRS 1
hypercholesterolemia 1
tuberous sclerosis 1
Biotinidase deficiency 1
Nonalcoholic fatty liver 1
DWI 1
polycythemia 1
Reye 1
dysphasia 1
glycogen storage disease 1
nystagmus 1
disorders of amino acid metabolism 1
Organic acidemias 1
Forbes 1
ICP 1
Andersen 1
cystinuria 1
Friedreich's ataxia 1
Hers 1
gestational trophoblastic disease 1
magnesium deficiency 1
hypophosphatasia 1
seminal vesicles 1
ALD 1
papillary thyroid cancer 1
THC 1
mitochondrial disease 1
blindness 1
hypothyroidism 1
adenoma 1
HCA 1
Ondine's curse 1
cytomegalovirus 1
rash 1
Carcinoma ex pleomorphic adenoma 1
gastric cancer 1
GSD I 1
dermatitis 1
addiction 1
profound mental retardation 1
Goodall 1
severe mental retardation 1
deafness 1
Avian reticuloendotheliosis 1
more...
Symptom
starvation 20
seizures 12
hypotonia 10
lethargy 7
vomiting 6
exhaustion 5
anesthesia 4
ataxia 4
dystonia 2
hypothermia 2
anorexia 2
abdominal pain 1
cerebellar ataxia 1
fatigue 1
consciousness disturbance 1
Ill 1
hunger 1
Spots 1
hypercapnia 1
spasticity 1
respiratory distress 1
tachypnea 1
myoclonus 1
constipation 1
dyspnea 1
agitation 1
Tissue anoxia 1
hepatomegaly 1
acidity 1
collapse 1
ketonuria 1
incoordination 1
hemiplegia 1
tremor 1
Drug
citric acid 66
NADH 64
lysine 44
lactose 12
Glucagon 11
CSF 7
Alanine 6
Glycerol 5
Ethanol 5
Gel 4
ROS 4
Fructose 3
DMI 3
Arsenic trioxide 3
FAD 3
ascorbate 2
Asn 2
Citric acid 2
Posilac 2
vitamin E 1
Formycin 1
ALA 1
Leaf 1
Aloe 1
pyridoxal phosphate 1
Colombo 1
CDX 1
Tween 40 1
Dermatol 1
Galactose 1
THF 1
G418 1
Pentostam 1
Corn oil 1
Honey 1
CDP 1
Vitamin B 1
Sodium valproate 1
PCB 1
caffeine 1
MRC 1
MAP 1
Glutamic acid 1
p-Chlorophenyl 1
Aspartic Acid 1
Monensin 1
Nitric Oxide 1
Clofibrate 1
Bezafibrate 1
CDX 1
NH3 1
Enzyme
pyruvate carboxylase 1516
phosphoenolpyruvate carboxykinase 296
phosphoenolpyruvate carboxykinase 296
phosphoenolpyruvate carboxykinase 296
pyruvate dehydrogenase 206
pyruvate dehydrogenase 171
pyruvate dehydrogenase 171
pyruvate kinase 90
phosphoenolpyruvate carboxylase 84
glucose-6-phosphatase 81
malate dehydrogenase 75
citrate synthase 71
acetyl-CoA carboxylase 61
lactate dehydrogenase 59
propionyl-CoA carboxylase 52
propionyl-CoA carboxylase 51
isocitrate dehydrogenase 50
isocitrate dehydrogenase 48
glutamine synthetase 45
glutamate dehydrogenase 43
glutamate dehydrogenase 43
glutamate dehydrogenase 43
fructose 1,6-bisphosphatase 42
biotin carboxylase 40
phosphofructokinase 40
aspartate aminotransferase 38
methylcrotonyl-CoA carboxylase 33
fumarase 27
hexokinase 27
alpha-ketoglutarate dehydrogenase 26
alanine aminotransferase 26
succinate dehydrogenase 25
isocitrate lyase 25
glucokinase 24
glucose-6-phosphate dehydrogenase 23
aconitase 19
biotinidase 17
glyceraldehyde-3-phosphate dehydrogenase 16
luciferase 15
superoxide dismutase 14
transcarboxylase 14
carbonic anhydrase 14
oxaloacetate decarboxylase 14
pyruvate decarboxylase 14
glutaminase 13
ATPase 12
ATP synthase 12
malate synthase 12
protein kinase 11
catalase 11
ACE 11
PDH 10
glyceraldehyde-3-phosphate dehydrogenase 10
AMP-activated protein kinase 10
rubisco 10
alkaline phosphatase 9
6-phosphogluconate dehydrogenase 9
alcohol dehydrogenase 9
CPS 9
6-phosphogluconate dehydrogenase 9
glycerol-3-phosphate dehydrogenase 9
glycerol-3-phosphate dehydrogenase 9
ornithine transcarbamylase 9
ACS 8
glyceraldehyde-3-phosphate dehydrogenase 8
glyceraldehyde-3-phosphate dehydrogenase 8
citrate lyase 8
succinic dehydrogenase 7
acyl-CoA synthetase 7
EC 1.1.1.40 7
cytochrome oxidase 7
glyceraldehyde-3-phosphate dehydrogenase 7
PDK1 7
CPT 7
acetate kinase 7
phosphoglycerate kinase 7
aspartokinase 7
diaphorase 7
argininosuccinate synthetase 6
urease 6
diaphorase 6
acyl-CoA synthetase 6
HSD 6
protein kinase C 6
acyl-CoA dehydrogenase 6
transhydrogenase 6
phosphorylase 6
acetyl-CoA synthetase 5
beta-hydroxybutyrate dehydrogenase 5
complex I 5
pyruvate:ferredoxin oxidoreductase 5
adenylate cyclase 5
AMPK 5
peroxidase 5
trypsin 5
aldehyde dehydrogenase 5
formate dehydrogenase 5
mitogen-activated protein kinase 5
formate dehydrogenase 5
RNA polymerase 5
fumarate reductase 5
arginase 5
acyl-CoA dehydrogenase 5
HMG-CoA synthase 5
formate dehydrogenase 5
PTA 4
adenylate kinase 4
glucose dehydrogenase 4
aldehyde dehydrogenase 4
enolase 4
oxoglutarate dehydrogenase 4
aldehyde dehydrogenase 4
alcohol oxidase 4
aldolase 4
carnitine acetyltransferase 4
PPDK 4
diacylglycerol acyltransferase 4
AMPK 4
aldehyde dehydrogenase 4
aldehyde dehydrogenase 4
lipoprotein lipase 4
transketolase 4
branched-chain aminotransferase 4
urease 3
asparagine synthetase 3
sucrose synthase 3
ascorbate peroxidase 3
geranoyl-CoA carboxylase 3
diaminopimelate dehydrogenase 3
6-phosphogluconate dehydratase 3
glutamic dehydrogenase 3
peroxiredoxin 3
CPR 3
MDH 3
phosphoglucose isomerase 3
branched-chain alpha-keto acid dehydrogenase 3
beta-glucuronidase 3
CPT 3
P-glycoprotein 3
beta-galactosidase 3
phosphoenolpyruvate synthase 3
CPT 3
firefly luciferase 3
glutathione S-transferase 3
MDH 3
reverse transcriptase 3
glycerol kinase 3
transaldolase 3
phosphodiesterase 3
HCS 3
carbamoylphosphate synthetase 3
nitrate reductase 2
alcohol acetyltransferase 2
nitrate reductase 2
pyruvate oxidase 2
nitrate reductase 2
lipoate acetyltransferase 2
nicotinic acid phosphoribosyltransferase 2
GABA transaminase 2
NADH dehydrogenase 2
more...
Compound
glucose 632
glutamate 229
ATP 191
glutamine 170
alanine 152
acetyl-CoA 152
phosphate 135
CoA 130
CO2 122
acetate 96
Dec 96
glycerol 83
2-oxoglutarate 82
ADP 75
ADP 74
ADP 74
TCA 70
NAD 68
NADH 64
DNA 54
oxygen 53
pentose 52
pentose 51
pentose 51
pentose 51
NAD 49
NADP 49
urea 48
lysine 46
nitrogen 44
NADPH 40
NADPH 40
ethanol 38
Pyruvate 35
GABA 35
GABA 35
AMP 35
oxalacetate 34
sodium 33
Biotin 33
ammonia 32
malic acid 31
water 29
methionine 27
serine 26
Clin 26
malic acid 25
Glutamate 25
ammonium 25
isocitrate 24
malic acid 24
PEP 24
carbonate 24
malic acid 24
succinic acid 21
calcium 21
Mg2+ 20
Lactate 20
threonine 20
Asp 18
arginine 18
manganese 17
acetic acid 17
proline 16
Insulin 16
succinic acid 15
succinic acid 15
sulfate 15
galactose 15
succinic acid 15
succinic acid 15
leucine 15
cAMP 14
His 14
aspartic acid 14
Flux 14
glucose-6-phosphate 13
HCO 13
glutamic acid 12
gamma-aminobutyric acid 12
asparagine 12
phenylacetic acid 12
cadmium 12
phenylacetic acid 11
SDS 11
Glutamine 11
ornithine 11
cysteine 11
ornithine 11
ornithine 11
phenylacetic acid 11
Glucagon 11
ornithine 11
ornithine 11
3-methylcrotonyl-CoA 11
phenylacetic acid 11
salt 10
alloxan 10
potassium 10
hexose 10
hexose 10
PDH 10
hexose 10
hexose 10
Carbon 9
3-hydroxyisovaleric acid 9
PYC 9
malonyl-CoA 9
oxalate 9
dicarboxylic acid 9
tryptophan 8
perchloric acid 8
GTP 8
tryptophan 8
tryptophan 8
valine 8
nicotinamide 8
CIT 8
alcohol dehydrogenase 8
tryptophan 8
aspartic acid 7
xylose 7
NH2 7
adenylate 7
tyrosine 7
hydroxycinnamic acid 7
aspartic acid 7
methanol 7
aspartic acid 7
nitrate 7
Cereb 7
hydrogen 6
Malate 6
Alanine 6
zinc 6
iron 6
nitric oxide 6
MAL 6
Ile 6
Dexamethasone 6
pyrimidine 6
2-oxobutyrate 5
C-3 5
Oleic acid 5
Pyruvate kinase 5
selenium 5
PEG 5
2-oxobutyrate 5
GSH 4
cobalt 4
isoleucine 4
Propionate 4
propylene glycol 4
GSH 4
phosphorus 4
TPP 4
acrylamide 4
6-phosphogluconate 4
cyanide 4
Diabetol 4
more...