Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound   Target Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound

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Query: EC:6.4.1.1 (pyruvate carboxylase)
1,516 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

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Human Gene/Protein pyruvate carboxylase 1416 phosphoenolpyruvate carboxykinase 239 ATP 191 insulin 179 pyruvate dehydrogenase 171 Pyruvate carboxylase 166 CO2 102 Sep 92 pyruvate kinase 87 NMR 82 glucose-6-phosphatase 77 ADP 74 malate dehydrogenase 71 phosphoenolpyruvate carboxylase 70 TCA 67 citrate synthase 66 NADH 63 glucagon 62 Mol 61 acetyl-CoA carboxylase 59 lactate dehydrogenase 56 NAD 49 propionyl-CoA carboxylase 48 isocitrate dehydrogenase 46 glutamine synthetase 45 glutamate dehydrogenase 42 NADPH 40 biotin carboxylase 40 NADP 36 aspartate aminotransferase 35 GABA 35 phosphatase 34 pyruvate dehydrogenase complex 34 phosphofructokinase 33 AMP 31 polypeptide 28 hexokinase 26 Pseudomonas 26 fumarase 25 glucokinase 23 alanine aminotransferase 22 NAD+ 21 INS-1 18 biotinidase 17 Gen 17 carbonic anhydrase 17 PEP 17 holocarboxylase synthetase 17 fructose-1,6-bisphosphatase 16 PEPCK 16 fatty acid synthase 15 carboxylating 15 fructose 1,6-bisphosphatase 15 glucose-6-phosphate dehydrogenase 14 aconitase 14 glucose transporter 14 superoxide dismutase 14 threonine 14 ASCI 13 glutaminase 12 decarboxylating 12 2-oxoglutarate dehydrogenase 12 ATPase 12 ACL 12 PCK1 11 catalase 11 NEFA 11 long chain 11 PDH 11 C18 11 SDS 10 Net 10 peroxisome proliferator-activated receptor 10 alpha-ketoglutarate dehydrogenase 10 cytochrome c oxidase 10 epididymal 9 casein 9 G6Pase 9 Malic enzyme 9 alkaline phosphatase 9 Pyruvate dehydrogenase 9 6-phosphogluconate dehydrogenase 9 GTP 8 glycolytic enzyme 8 ATP citrate lyase 8 alcohol dehydrogenase 8 glyceraldehyde 3-phosphate dehydrogenase 8 C-1 8 CA V 8 NADP+ 7 CSF 7 PCK2 7 ornithine transcarbamylase 7 PEPCK-C 7 glyceraldehyde-3-phosphate dehydrogenase 7 insulin receptor 7 acetyl-CoA synthetase 6 argininosuccinate synthetase 6 6-phosphofructokinase 6 CA II 6 acyl-CoA synthetase 6 oxoglutarate 6 AMP-activated protein kinase 6 carbamoylphosphate synthetase 6 dimeric 6 Holocarboxylase synthetase 6 carnitine palmitoyltransferase 6 albumin 6 carnitine palmitoyltransferase 1A 6 3-hydroxybutyrate dehydrogenase 5 Carbonic anhydrase 5 asymmetrical 5 acyl-CoA dehydrogenase 5 lipoamide dehydrogenase 5 reductase 5 leptin 5 PGC 5 She 5 histone 5 A-I 5 ATP synthase 5 Pyruvate kinase 5 housekeeping 5 endoplasmic reticulum 5 cytochrome c 5 aconitate hydratase 5 ACC 5 phosphoglycerate kinase 5 microsomal 5 peroxidase 5 Malate dehydrogenase 5 pyruvate dehydrogenase kinase 5 phosphoenolpyruvate carboxykinase 1 4 glucose dehydrogenase 4 penumbra 4 N-acetylaspartate 4 NIDDM 4 glycogen synthase 4 ACC1 4 USF1 4 PPAR 4 insulin-like growth factor-I 4 haptoglobin 4 aldehyde dehydrogenase 4 serum albumin 4 transketolase 4 adenylate kinase 4 Isocitrate dehydrogenase 4 peroxisome proliferator-activated receptor gamma 4 Met 4 enolase 4 AMPK 4 lipoprotein lipase 4 ROS 4 E1 alpha 4 adenylate cyclase 4 GSH 4 PEPCK-M 4 homeobox 4 HMG-CoA synthase 4 carnitine acetyltransferase 3 phosphoglucose isomerase 3 NADP-dependent isocitrate dehydrogenase 3 cytokine 3 transcriptional regulator 3 X-linked 3 NADP-malic enzyme 3 adipose triglyceride lipase 3 yeast) 3 ubiquitin 3 PTS 3 phosphodiesterase 3 acetyl-CoA carboxylase 1 3 solute carrier 3 pyruvate carboxylase, mitochondrial 3 CPT1 3 CA IV 3 catenin 3 lipopolysaccharide 3 calmodulin 3 cytochrome 3 GDP 3 Glucose-6-phosphatase 3 PCC 3 IRS-1 3 ANOVA 3 vasopressin 3 ACS 3 Sp1 3 beta-glucuronidase 3 insulin-like growth factor 3 Citrate synthase 3 CO3 3 CPS 3 glutamic acid decarboxylase 3 MDH 3 CPT 3 P-glycoprotein 3 HBA 3 glutathione S-transferase 3 IGF-I 3 transaldolase 3 metallothionein 3 microsomal triglyceride transfer protein 3 oxidoreductase 3 serum protein 3 LDH 3 phosphorylating 3 proximal tubule 3 USF2 3 glucose transporter 4 3 glycogen phosphorylase 3 isocitric dehydrogenase 3 MSU 3 Tumor necrosis factor 3 glutamic dehydrogenase 3 esterase 3 growth hormone 3 muscle protein 3 FAD 3 TOF 2 gut 2 hemoglobin 2 Glutamine synthetase 2 vimentin 2 SNAP 2 beta-adrenergic receptor kinase 2 H-protein 2 SAS 2 tRNA 2 estrogen receptor 2 ODPA 2 pyruvate dehydrogenase kinase 4 2 nicotinic acid phosphoribosyltransferase 2 OPA3 2 OTC 2 PCT 2 HMG-CoA reductase 2 glutamate pyruvate transaminase 2 membrane protein 2 carbonic anhydrase II 2 Aspartate aminotransferase 2 ACTH 2 IDP 2 A. nidulans 2 CA5 2 preproinsulin 2 BCATm 2 3-hydroxyacyl-CoA dehydrogenase 2 NADP-ME 2 ME3 2 IL-6 2 Fas 2 isocitrate dehydrogenase 1 2 PDC 2 interferon 2 sorbitol dehydrogenase 2 MCT1 2 glycerol kinase 2 lactate dehydrogenase A 2 LL) 2 PDK4 2 phosphate-activated glutaminase 2 CD36 2 fused 2 PDK 2 fatty acid binding protein 2 MDR1 2 ornithine decarboxylase 2 caspase-3 2 mTOR 2 UTR 2 tumor necrosis factor 2 PDX-1 2 PDK1 2 PDK2 2 RNase 2 DNA-binding protein 2 precursor protein 2 Pol 2 transcriptional repressor 2 hormone-sensitive lipase 2 MnSOD 2 methionine synthase 2 L-lactate dehydrogenase 2 Chlamydomonas 2 unknown function 2 MDH2 2 DDT 2 prohibitin 2 GMP 2 ME1 2 apolipoprotein B 2 glucosamine 2 spermatozoa 2 ME2 2 sodium-dependent multivitamin transporter 2 PC2 2 D-fructose-1,6-bisphosphate 1-phosphohydrolase 2 glycine decarboxylase 2 erythropoietin 2 mitochondrial aconitase 2 PAO 2 CREB 2 p53 2 pyrophosphatase 2 tumor necrosis factor alpha 2 HEK 2 TNF 2 tyrosine hydroxylase 2 glutathione reductase 2 glycerol-3-phosphate dehydrogenase 2 granulocyte 2 chymotrypsin 2 cryptic 2 BCH 2 quinone oxidoreductase 2 lactate dehydrogenase-A 2 D-lactate dehydrogenase 2 phosphoglyceromutase 2 serine dehydratase 2 diacylglycerol acyltransferase 2 c-Myc 2 ACC2 2 cytochrome aa3 2 FBP1 2 fructose-1,6-bisphosphatase 1 2 MDH1 2 Rett syndrome 2 GTPase 2 Glucokinase 2 NO3 2 NADH dehydrogenase 2 stearoyl-CoA desaturase 2 alpha 4 2 Phosphofructokinase 2 lipase 2 TFAM 2 GABA transaminase 1 phosphatidylinositol 3-kinase 1 AAT 1 Fructose 1,6-bisphosphatase 1 carbohydrate response element binding protein 1 E-cadherin 1 HSP70 1 ATPase homolog 1 ALA 1 TIM 1 PSPH 1 cAMP response element binding protein 1 enigma 1 MCCC1 1 SREBP-2 1 perilipin 1 S100A6 1 BMI-1 1 inducible nitric oxide synthase 1 Prolactin 1 PLA 1 p62 1 fumarate hydratase 1 PGA 1 CRC 1 MMP-9 1 GLP-1 1 MUL 1 glutathione synthetase 1 CSL 1 differentially expressed protein 1 CA1 1 STZ 1 PCA 1 MAEA 1 ORF1 1 PI3 1 phosphoglycerate dehydrogenase 1 c-fos 1 ACSL3 1 PK2 1 phosphoenolpyruvate carboxykinase 2 1 4E-BP1 1 ATF3 1 Glyceraldehyde-3-phosphate dehydrogenase 1 EST 1 mitochondrial carrier 1 JNK 1 MPP 1 MAPK 1 calcitonin 1 galactose-1-phosphate uridyltransferase 1 MCP 1 oxytocin 1 PGK 1 C1/C2 1 nitric oxide synthase 1 ALS 1 Ah receptor 1 hinge 1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 PROC 1 FBP 1 PKR 1 ceruloplasmin 1 Growth hormone 1 retinoic acid-inducible gene 1 1 brush border 1 lipoamide 1 MCT 1 MIC 1 regulated by glucose 1 PBG 1 TSPY 1 NADH-ubiquinone reductase 1 STAT 1 ASC 1 SLC2A4 1 colon carcinoma 1 nodal 1 TIP47 1 NOX3 1 sulfite oxidase 1 CDP 1 PS1 1 FDG 1 calreticulin 1 proinsulin 1 LDH-A 1 neuron-specific enolase 1 dihydrodipicolinate synthase 1 aquaporin-4 1 hexokinase 1 1 member 1 1 PGC1A 1 GRO 1 ALD 1 mitofusin 1 1 ORF 1 BMAL1 1 methyltransferase 1 glutamate receptor 1 FAT 1 Glutaminase 1 NAMPT 1 heme oxygenase-1 1 macrophage colony-stimulating factor 1 TOP2 beta 1 mitochondrial carrier protein 1 ACSS3 1 DIO2 1 hormone receptor 1 mitochondrial citrate transport protein 1 cardiac muscle 1 succinic semialdehyde dehydrogenase 1 ESI 1 FSP27 1 acyl-CoA oxidase 1 caveolin-1 1 NOR-1 1 inhibitor 2 1 DCS 1 BB1 1 fur 1 aldolase C 1 PER 1 ACADVL 1 angiotensin II 1 PC1 1 ERK1 1 CAIV 1 ACSL1 1 acetolactate synthase 1 AIP 1 cys 1 inorganic pyrophosphatase 1 FBPase 1 GC1 1 14-3-3 1 HXB 1 frataxin 1 CPT II 1 S-adenosylhomocysteine hydrolase 1 BID 1 citrate transport protein 1 farnesoid X receptor 1 glutaredoxin 1 glial fibrillary acidic protein 1 sodium-glucose cotransporter 1 NRC 1 hole 1 CS-3 1 ATF5 1 cannabinoid receptor 1 LPL 1 THC 1 D-serine 1 TALH 1 SDHB 1 mitofilin 1 GPD1 1 Fibroblast growth factor 21 1 Huntingtin 1 glutamate decarboxylase 1 ANP 1 LDH-B 1 forkhead/winged helix transcription factor 1 FGF19 1 Max-like protein X 1 phosphoserine aminotransferase 1 Kir6.2 1 Nicotinamide nucleotide transhydrogenase 1 CB2 1 beta tubulin 1 HMP 1 H. influenzae 1 ATP5J2 1 BRAF 1 Nurr1 1 alternative protein 1 CDD 1 phosphoglucomutase 1 1 C10 1 thioredoxin interacting protein 1 HDL 1 visfatin 1 myosin heavy chain 1 orphan nuclear receptor 1 axonal 1 Leptin 1 nuclear hormone receptor 1 prolactin 1 pancreatic and duodenal homeobox 1 1 cAMP-dependent protein kinase 1 SSB1 1 apyrase 1 NTP 1 lipoxygenase 1 acid phosphatase 1 transmembrane glycoprotein 1 regucalcin 1 methylmalonyl-CoA mutase 1 soxB 1 ferredoxin 1 elongation factor 1-alpha 1 insulin-like growth factor 1 1 GDH2 1 PEG 1 NR1D1 1 Barth syndrome 1 NMDA receptor 1 BPC1 1 MSUD 1 FDP 1 NAD kinase 1 IGF-1 1 sterol regulatory element-binding protein 1 NeuroD 1 ras 1 PKA 1 LDH-X 1 atrial natriuretic factor 1 CGI-49 1 Caspase-1 1 PI3K 1 SARP 1 HPI 1 GLS 1 HLA 1 mitogen-activated protein 1 RNA-binding protein 1 neuronal nitric oxide synthase 1 insulin receptor substrate 1 MRS 1 ACO 1 thioredoxin 1 acyl-CoA dehydrogenase 9 1 FISH 1 lectin 1 MOT 1 mouse) 1 IL10 1 G6PD 1 Phosphoserine phosphatase 1 carnitine palmitoyltransferase I 1 alternatively spliced 1 FXR 1 creatine kinase 1 RagD 1 growth hormone receptor 1 Glycerol kinase 1 glucagon receptor 1 amylin 1 SP-2 1 alanyl 1 RDP 1 Fibroblast growth factor 1 arylsulfatase E 1 nuclear protein 1 manganese superoxide dismutase 1 CMP 1 AB3 1 NARP 1 GLUT-2 1 adenosyltransferase 1 methylmalonate-semialdehyde dehydrogenase 1 p12 1 IRS-2 1 apoE 1 muscle glycogen phosphorylase 1 MCP-1 1 gastrin 1 villin 1 Prohibitin 1 betaine-homocysteine methyltransferase 1 steroid dehydrogenase-like protein 1 SREBP-1c 1 HCS 1 myogenin 1 N-acetyltransferase 1 succinyl-CoA:3-ketoacid-CoA transferase 1 carbonic anhydrase III 1 hepatocyte nuclear factor 1 alpha 1 NIR 1 USF 1 SP-22 1 glycoprotein 1 SCOT 1 glucose-dependent insulinotropic polypeptide 1 carbamoylphosphate synthetase I 1 B10 1 ASCL1 1 methylenetetrahydrofolate dehydrogenase 1 PFL 1 period 3 1 UCP2 1 MRC 1 epidermal growth factor 1 Raf kinase inhibitor protein 1 lactase 1 metalloendopeptidase 1 ATF4 1 GSTM 1 SLC19A3 1 acetyl-CoA carboxylase alpha 1 PHGDH 1 NADH2 1 DAG 1 peptidyl-prolyl cis-trans isomerase 1 HMG-CoA lyase 1 UCP3 1 focal adhesion kinase 1 adipophilin 1 IDH2 1 Epidermal growth factor 1 matrix metalloproteinase 1 cyclophilin 1 GC2 1 adiponectin 1 EGP 1 AGC1 1 SDHC protein 1 period 2 1 ash 1 GTT 1 OXPHOS 1 RPL32 1 glutamate carrier 1 STAT3 1 gamma-glutamyl transpeptidase 1 ferritin 1 rhabdomyosarcoma 1 MLP 1 GSK 1 ASNS 1 beta-ketothiolase 1 S3-12 1 long-chain acyl-CoA dehydrogenase 1 MCT4 1 CS1 1 monocarboxylate transporter 4 1 EPR 1 glutathione peroxidase 1 trypsin inhibitor 1 ALF 1 Zap 1 MRI 1 BCS 1 PSAT1 1 5-methyltetrahydrofolate-homocysteine methyltransferase 1 CA VII 1 collagenase 1 fumarylacetoacetate hydrolase 1 PGF 1 glycerol-3-phosphate dehydrogenase 1 1 EHD2 1 bcl-2 1 prolidase 1 fatty-acid synthase 1 MIP-1beta 1 CHL 1 parathyroid hormone 1 A20 1 heat shock protein 1 citrin 1 IST1 1 integral membrane protein 1 GAL4 1 acetoacetyl-CoA synthetase 1 beta-tubulin 1 adrenocorticotropic hormone 1 elongation factor 2 1 IP3R1 1 COXI 1 MCD 1 LYS5 1 vasoactive intestinal peptide 1 phosvitin 1 LYS2 1 STAT1 1 enoyl-CoA hydratase 1 GSD 1 CYP 1 adenyl cyclase 1 asparagine synthetase 1 HKII 1 GCR 1 LeuRS 1 DHFR 1 Cyclin D1 1 ubiquinol-cytochrome c reductase complex 1 GLUT2 1 EPO 1 tafazzin 1 SLC2A2 1 glucocorticoid receptor 1 ADP/ATP translocase 1 Dictyostelium 1 Thioredoxin 1 serum amyloid A 1 BAK1 1 SESN2 1 PHB 1 HPA 1 cytochrome P450 1 rat) 1 histone H3 1 V75 1 E2A 1 TCB 1 Phosphoglycerate dehydrogenase 1 NM23-H2 1 diaphorase 1 D54 1 PEX10 1 PDC2 1 cage 1 galactosyltransferase 1 thyroid hormone 1 apolipoprotein E 1 forkhead transcription factor 1 lymphoid 1 TAT 1 SLC25A1 1 PMS 1 PKC 1 H2B 1 LPMC 1 Apolipoprotein E 1 putative transcription factor 1 Walker 1 TPP 1 ribosomal protein 1 DJ-1 1 O-GlcNAc transferase 1 D-amino acid oxidase 1 SDHC 1 transferrin 1 NAD-malic enzyme 1 CFI 1 K12 1 G6PDH 1 Fructose-1,6-bisphosphatase 1 SRC-1 1 UMP-CMP kinase 1 LSS 1 ME4 1 ferrochelatase 1 islet-specific glucose-6-phosphatase catalytic subunit-related protein 1 aminopeptidase N 1 collagen 1 CLOCK 1 elongation factor Tu 1 Phosphorylase 1 zinc finger protein 1 hexokinase 2 1 HAK 1 huntingtin 1 delta-aminolevulinate synthase 1 IL1B 1 amylase 1 wts 1 PCB 1 protein disulfide isomerase 1 MCC 1 OST1 1 FDH 1 MCCC2 1 retinoid X receptor alpha 1 pyridine nucleotide transhydrogenase 1 cytosolic malate dehydrogenase 1 CS-1 1 MELAS 1 sarcosine dehydrogenase 1 SGC 1 BAT 1 PCCB 1 zinc finger transcription factor 1 Nkx6.1 1 HMGCS2 1 SGT1 1 aldolase B 1 Maltase 1 MASCOT 1 6PGD 1 Spot14 1 glycerokinase 1 ABC transporter 1 H2A 1 MDM2 1 non-functional 1 IKK 1 NADP+-dependent isocitrate dehydrogenase 1 ICP 1 Stearoyl-CoA desaturase 1 liver glycogen synthase 1 carbonic anhydrase IX 1 UDPG 1 pantothenate kinase 1 apoB-100 1 peptidase 1 protein kinase B 1 pccA 1 ADC 1 pseudogene 1 translationally controlled tumor protein 1 methylenetetrahydrofolate reductase 1 ACK 1 vinculin 1 peroxisome proliferator-activated receptor alpha 1 motor protein 1 interleukin-6 1 hydroxymethylglutaryl-CoA synthase 1 CS-2 1 thymus 1 Na+/glucose cotransporter 1 MKP-1 1 cytoskeletal protein 1 C-terminal peptide 1 TCF3 1 MxA 1 long-chain acyl-CoA synthetase 1 L-alanine:glyoxylate aminotransferase 1 Bot 1 3 beta-HSD 1 variant 1 1 BNIP3 1 kinesin 1 acetaldehyde dehydrogenase 1 SLC22A5 1 transcriptional coactivator 1 carbonic anhydrase VI 1 phospholipase D 1 cytokeratin 18 1 DTNB 1 vasodilator-stimulated phosphoprotein 1 alpha polypeptide 1 HMGCS1 1 AST 1 protein X 1 p160 1 membrane-bound 1 Metallothionein 1

Disease diabetes 53 lactic acidosis 39 hypoglycemia 38 cancer 33 type 2 diabetes 29 tumor 28 hyperglycemia 25 fatty liver 21 PC deficiency 20 Leigh syndrome 18 obesity 15 depression 13 Biotin deficiency 11 cold 10 breast cancer 10 encephalopathy 10 SDS 10 Mycobacterium 9 insulinoma 8 epilepsy 8 hepatocellular carcinoma 7 ketosis 6 glucose intolerance 6 glioma 6 hepatic encephalopathy 6 ischemia 6 Reye's syndrome 6 coma 5 malnutrition 4 MCF 4 fits 4 GSH 4 tuberculosis 4 mole 4 methylmalonic acidemia 4 Alzheimer's disease 4 dehydration 4 propionic acidemia 4 renal tubular acidosis 4 metabolic disorder 4 pheochromocytoma 4 sepsis 4 mole 4 mental retardation 4 stroke 4 mental retardation 4 developmental delay 3 influenza 3 Parkinson's disease 3 non-small cell lung cancer 3 melanoma 3 tumorigenesis 3 glioblastoma 3 hyperlysinemia 3 citrullinemia 3 sepsis 3 astrocytoma 3 porphyria 3 status epilepticus 3 type 1 diabetes 3 hyperlipidemia 3 Huntington's disease 3 PCC 3 brain edema 3 hyperthyroidism 3 tumor growth 3 lung cancer 3 virus infection 3 Syndrome 2 genetic disorder 2 liver disease 2 adenocarcinoma 2 encephalomyelopathy 2 iron deficiency 2 lipidosis 2 West 2 Rett syndrome 2 failure to thrive 2 glutaric aciduria 2 metabolic syndrome 2 Wernicke's encephalopathy 2 heart failure 2 ovarian cancer 2 myopathy 2 carcinoma 2 SEM 2 brain atrophy 2 MGA3 2 neuroblastoma 2 Benson 2 Alpers 2 PDC 2 BCH 2 porphyria cutanea tarda 2 respiratory failure 2 Multiple carboxylase deficiency 2 mitochondrial encephalomyopathy 2 Brown 2 renal cell carcinoma 2 colon cancer 2 mitochondrial myopathy 2 paraganglioma 2 MILS 1 quadriparesis 1 renal insufficiency 1 anaplastic astrocytoma 1 lymphoma 1 MELAS 1 herpes simplex 1 kidney hypertrophy 1 reticuloendotheliosis 1 brucellosis 1 neurological disease 1 dyslipidemia 1 cystic fibrosis 1 PCA 1 MRS 1 hypercholesterolemia 1 tuberous sclerosis 1 Biotinidase deficiency 1 Appendix 1 uterus 1 alkalosis 1 Sutton 1 rare disease 1 pneumonia 1 lung metastases 1 Schistosoma mansoni 1 bronchopneumonia 1 polycythemia 1 Reye 1 dysphasia 1 glycogen storage disease 1 nystagmus 1 disorders of amino acid metabolism 1 Forbes 1 ICP 1 Andersen 1 cystinuria 1 Friedreich's ataxia 1 Hers 1 mitochondrial disease 1 blindness 1 enzyme deficiency 1 magnesium deficiency 1 gallbladder cancer 1 adenoma 1 hypophosphatasia 1 RDP 1 Ondine's curse 1 GSD I 1 dermatitis 1 addiction 1 gestational trophoblastic disease 1 wasting 1 amyotrophic lateral sclerosis 1 IVA 1 papillary thyroid cancer 1 Ketonemia 1 THC 1 cerebral palsy 1 ALD 1 seminal vesicles 1 preeclampsia 1 Ondine's curse 1 Klebsiella 1 infestation 1 cytomegalovirus 1 APC 1 premenstrual syndrome 1 hypothyroidism 1 HCA 1 tapeworm 1 MCD 1 rash 1 stomatitis 1 Carcinoma ex pleomorphic adenoma 1 gastric cancer 1 Kearns-Sayre syndrome 1 profound mental retardation 1 severe mental retardation 1 congestive heart failure 1 sarcoma 1 deafness 1 Avian reticuloendotheliosis 1 kwashiorkor 1 Barth syndrome 1 Goodall 1 cardiomyopathy 1 GSD 1 yellow fever 1 MELAS 1 worms 1 diabetic ketoacidosis 1 hypernatremia 1 parkinsonism 1 acute leukemia 1 gastroenteritis 1 Haemophilus 1 diabetic neuropathy 1 parasitic disease 1 marasmus 1 Mycoplasma 1 Ewing's sarcoma 1 zoonosis 1 tumor progression 1 listeriosis 1 sudden infant death syndrome 1 hemiparesis 1 memory impairment 1 laryngospasm 1 hepatic porphyria 1 Still 1 chronic renal insufficiency 1 uremia 1 ash 1 abortion 1 HPA 1 maple syrup urine disease 1 PMS 1 cor pulmonale 1 pancreatic cancer 1 macrocephaly 1 arthritis 1 hyperphagia 1 AIN 1 Appendix 1 agranulocytosis 1 Appendix 1 cleft palate 1 PCT 1 Acute liver failure 1 clonorchiasis 1 marijuana abuse 1 epithelial ovarian cancer 1 brain tumor 1 acute intermittent porphyria 1 invasive cancer 1 cirrhosis 1 affective disorder 1 thyroid cancer 1 AIP 1 plant disease 1 hepatitis C 1 AIP 1 peripheral neuropathy 1 Evans 1 telangiectasia 1 Nonalcoholic fatty liver 1 thiamine deficiency 1 DWI 1 Anisakis 1 Korsakoff's syndrome 1 hypertension 1 GSD 1 PDH deficiency 1 hyperphenylalaninemia 1 Merkel cell carcinoma 1 Mitchell 1 gestational diabetes mellitus 1 atherosclerosis 1 PER 1 cerebral ischemia 1 Organic acidemias 1 leukemia 1 parakeratosis 1 epididymis 1 retinopathy of prematurity 1 PGA 1 alcoholic fatty liver 1 FDH 1 Pulmonary arterial hypertension 1 colorectal cancer 1

Symptom starvation 20 seizures 12 hypotonia 10 lethargy 7 vomiting 6 exhaustion 5 anesthesia 4 ataxia 4 dystonia 2 hypothermia 2 anorexia 2 abdominal pain 1 cerebellar ataxia 1 fatigue 1 consciousness disturbance 1 Ill 1 hunger 1 Spots 1 hypercapnia 1 spasticity 1 respiratory distress 1 tachypnea 1 myoclonus 1 constipation 1 dyspnea 1 agitation 1 Tissue anoxia 1 hepatomegaly 1 acidity 1 collapse 1 ketonuria 1 incoordination 1 hemiplegia 1 tremor 1

Drug citric acid 66 NADH 64 lysine 44 lactose 12 Glucagon 11 CSF 7 Alanine 6 Glycerol 5 Ethanol 5 Gel 4 ROS 4 Fructose 3 DMI 3 Arsenic trioxide 3 FAD 3 ascorbate 2 Asn 2 Citric acid 2 Posilac 2 vitamin E 1 Formycin 1 ALA 1 Leaf 1 Aloe 1 pyridoxal phosphate 1 Colombo 1 CDX 1 Tween 40 1 Dermatol 1 Galactose 1 THF 1 G418 1 Pentostam 1 Corn oil 1 Honey 1 CDP 1 Vitamin B 1 Sodium valproate 1 PCB 1 caffeine 1 MRC 1 MAP 1 Glutamic acid 1 p-Chlorophenyl 1 Aspartic Acid 1 Monensin 1 Nitric Oxide 1 Clofibrate 1 Bezafibrate 1 CDX 1 NH3 1

Enzyme pyruvate carboxylase 1516 phosphoenolpyruvate carboxykinase 296 phosphoenolpyruvate carboxykinase 296 phosphoenolpyruvate carboxykinase 296 pyruvate dehydrogenase 206 pyruvate dehydrogenase 171 pyruvate dehydrogenase 171 pyruvate kinase 90 phosphoenolpyruvate carboxylase 84 glucose-6-phosphatase 81 malate dehydrogenase 75 citrate synthase 71 acetyl-CoA carboxylase 61 lactate dehydrogenase 59 propionyl-CoA carboxylase 52 propionyl-CoA carboxylase 51 isocitrate dehydrogenase 50 isocitrate dehydrogenase 48 glutamine synthetase 45 glutamate dehydrogenase 43 glutamate dehydrogenase 43 glutamate dehydrogenase 43 fructose 1,6-bisphosphatase 42 biotin carboxylase 40 phosphofructokinase 40 aspartate aminotransferase 38 methylcrotonyl-CoA carboxylase 33 fumarase 27 hexokinase 27 alpha-ketoglutarate dehydrogenase 26 alanine aminotransferase 26 succinate dehydrogenase 25 isocitrate lyase 25 glucokinase 24 glucose-6-phosphate dehydrogenase 23 aconitase 19 biotinidase 17 glyceraldehyde-3-phosphate dehydrogenase 16 luciferase 15 oxaloacetate decarboxylase 14 carbonic anhydrase 14 pyruvate decarboxylase 14 superoxide dismutase 14 transcarboxylase 14 glutaminase 13 ATPase 12 ATP synthase 12 malate synthase 12 protein kinase 11 ACE 11 catalase 11 glyceraldehyde-3-phosphate dehydrogenase 10 AMP-activated protein kinase 10 PDH 10 rubisco 10 glycerol-3-phosphate dehydrogenase 9 alkaline phosphatase 9 alcohol dehydrogenase 9 6-phosphogluconate dehydrogenase 9 glycerol-3-phosphate dehydrogenase 9 CPS 9 ornithine transcarbamylase 9 6-phosphogluconate dehydrogenase 9 ACS 8 glyceraldehyde-3-phosphate dehydrogenase 8 glyceraldehyde-3-phosphate dehydrogenase 8 citrate lyase 8 acetate kinase 7 cytochrome oxidase 7 phosphoglycerate kinase 7 aspartokinase 7 acyl-CoA synthetase 7 diaphorase 7 succinic dehydrogenase 7 glyceraldehyde-3-phosphate dehydrogenase 7 CPT 7 EC 1.1.1.40 7 PDK1 7 urease 6 phosphorylase 6 diaphorase 6 argininosuccinate synthetase 6 acyl-CoA synthetase 6 HSD 6 protein kinase C 6 transhydrogenase 6 acyl-CoA dehydrogenase 6 complex I 5 acetyl-CoA synthetase 5 acyl-CoA dehydrogenase 5 formate dehydrogenase 5 arginase 5 HMG-CoA synthase 5 RNA polymerase 5 pyruvate:ferredoxin oxidoreductase 5 AMPK 5 peroxidase 5 trypsin 5 formate dehydrogenase 5 adenylate cyclase 5 aldehyde dehydrogenase 5 fumarate reductase 5 beta-hydroxybutyrate dehydrogenase 5 formate dehydrogenase 5 mitogen-activated protein kinase 5 enolase 4 lipoprotein lipase 4 transketolase 4 PTA 4 aldehyde dehydrogenase 4 branched-chain aminotransferase 4 glucose dehydrogenase 4 aldehyde dehydrogenase 4 diacylglycerol acyltransferase 4 adenylate kinase 4 aldolase 4 PPDK 4 AMPK 4 aldehyde dehydrogenase 4 aldehyde dehydrogenase 4 alcohol oxidase 4 carnitine acetyltransferase 4 oxoglutarate dehydrogenase 4 asparagine synthetase 3 ascorbate peroxidase 3 diaminopimelate dehydrogenase 3 firefly luciferase 3 peroxiredoxin 3 reverse transcriptase 3 MDH 3 glutathione S-transferase 3 CPT 3 urease 3 CPT 3 phosphoenolpyruvate synthase 3 beta-galactosidase 3 geranoyl-CoA carboxylase 3 beta-glucuronidase 3 P-glycoprotein 3 CPR 3 phosphoglucose isomerase 3 MDH 3 6-phosphogluconate dehydratase 3 glycerol kinase 3 glutamic dehydrogenase 3 transaldolase 3 sucrose synthase 3 phosphodiesterase 3 HCS 3 branched-chain alpha-keto acid dehydrogenase 3 carbamoylphosphate synthetase 3 lysine decarboxylase 2 EC 1.1.1.82 2 reductoisomerase 2 glycerol 3-phosphate dehydrogenase 2 citrate cleavage enzyme 2 lactic acid dehydrogenase 2 nitrate reductase 2 glutamate synthase 2 alcohol acetyltransferase 2 hormone-sensitive lipase 2 3-hydroxyacyl-CoA dehydrogenase 2 ECH 2 transcriptase 2 PGM 2 aspartase 2 glycine decarboxylase 2 glutamate synthase 2 threonine deaminase 2 glutathione reductase 2 SCS 2 caspase-3 2 pyruvate oxidase 2 ornithine decarboxylase 2 diaminopimelate decarboxylase 2 succinyl-CoA synthetase 2 phosphoglyceromutase 2 methionine synthase 2 lipoate acetyltransferase 2 nicotinic acid phosphoribosyltransferase 2 lactic acid dehydrogenase 2 invertase 2 tyrosine hydroxylase 2 lactic acid dehydrogenase 2 lipase 2 glutamate synthase 2 sorbitol dehydrogenase 2 3-hydroxyacyl-CoA dehydrogenase 2 NADH dehydrogenase 2 GABA transaminase 2 nitrate reductase 2 RNase 2 2-keto-3-deoxy-6-phosphogluconate aldolase 2 chymotrypsin 2 nitrate reductase 2 creatine kinase 2 nitrate reductase 2 CD13 2 acetolactate synthase 2 RNase 2 nitrate reductase 2 methionine synthase 2 acetoacetyl-CoA thiolase 2 pyruvate oxidase 2 nitrate reductase 2 3-oxoacid CoA-transferase 1 AGT 1 oxalate oxidase 1 tyrosine aminotransferase 1 glycerol dehydrogenase 1 glutamate decarboxylase 1 phospholipase D 1 gamma-glutamyl transpeptidase 1 TPP 1 ceruloplasmin 1 AST 1 sulfite oxidase 1 sulfite oxidase 1 O-GlcNAc transferase 1 peptidyl-prolyl cis-trans isomerase 1 3-hydroxy-3-methylglutaryl coenzyme A reductase 1 betaine-homocysteine methyltransferase 1 xylitol dehydrogenase 1 thermolysin 1 homoserine kinase 1 collagenase 1 phosphoglycerate dehydrogenase 1 uroporphyrinogen decarboxylase 1 acid phosphatase 1 phospholipase A2 1 CFI 1 alanine dehydrogenase 1 Mg-chelatase 1 EC 4.1.1.40 1 glycerophosphate phosphatase 1 uridyltransferase 1 endoproteinase Glu-C 1 heparinase 1 dihydrodipicolinate reductase 1 EC 2.4.1.11 1 acetolactate decarboxylase 1 succinic semialdehyde dehydrogenase 1 methylmalonate-semialdehyde dehydrogenase 1 prolidase 1 TPP 1 CAD 1 alanine aminopeptidase 1 MPP 1 phosphatidylinositol 3-kinase 1 CEP 1 benzoylformate decarboxylase 1 xylitol dehydrogenase 1 KAT 1 2-oxoglutarate decarboxylase 1 cystathionine beta-synthase 1 focal adhesion kinase 1 desulfinase 1 CMP kinase 1 xylulokinase 1 GapB 1 MDR 1 methylenetetrahydrofolate dehydrogenase 1 LPL 1 methylenetetrahydrofolate reductase 1 apyrase 1 CimA 1 IKK 1 Mg2+-ATPase 1 methylmalonyl-CoA mutase 1 dihydrofolate reductase 1 ACC synthase 1 methylenetetrahydrofolate dehydrogenase 1 10-formyltetrahydrofolate dehydrogenase 1 MDP 1 L-asparagine synthetase 1 cysteine synthase 1 desulfhydrase 1 GRK2 1 ALA synthase 1 p-nitrophenylphosphatase 1 methylenetetrahydrofolate reductase 1 condensing enzyme 1 acetoacetyl-CoA synthetase 1 alpha-glucosidase 1 glutathione peroxidase 1 pyruvate dehydrogenase phosphatase 1 sarcosine dehydrogenase 1 bile salt hydrolase 1 N-acetyltransferase 1 acetyl-CoA hydrolase 1 GSK 1 citramalate synthase 1 ferrochelatase 1 pyruvate formate-lyase 1 NADPH oxidase 1 dihydrodipicolinate synthase 1 NQO1 1 hydrogenase 1 HIV-1 protease 1 serine hydroxymethyltransferase 1 dihydrolipoamide succinyltransferase 1 ornithine aminotransferase 1 BAT 1 oxidosqualene cyclase 1 hydrogenase 1 glutathione synthetase 1 3-hydroxy-3-methylglutaryl-CoA reductase 1 arsenite oxidase 1 NADPH-diaphorase 1 lipoxygenase 1 EC 1.1.1.38 1 NADPH oxidase 1 EC 3.6.1.1 1 EC 1.1.1.39 1 kinesin 1 proteasome 1 N-acetylglutamate kinase 1 leucyl-tRNA synthetase 1 lactase 1 hydroxyprostaglandin dehydrogenase 1 pantothenate kinase 1 ribulose 5-phosphate 3-epimerase 1 fumarylacetoacetate hydrolase 1 fatty-acid synthase 1 acylpyruvate hydrolase 1 phosphoribulokinase 1 glycerol dehydrogenase 1 glucose permease 1 halogenase 1

Compound glucose 632 glutamate 229 ATP 191 glutamine 170 acetyl-CoA 152 alanine 152 phosphate 135 CoA 130 CO2 122 acetate 96 Dec 96 glycerol 83 2-oxoglutarate 82 ADP 75 ADP 74 ADP 74 TCA 70 NAD 68 NADH 64 DNA 54 oxygen 53 pentose 52 pentose 51 pentose 51 pentose 51 NADP 49 NAD 49 urea 48 lysine 46 nitrogen 44 NADPH 40 NADPH 40 ethanol 38 GABA 35 GABA 35 AMP 35 Pyruvate 35 oxalacetate 34 Biotin 33 sodium 33 ammonia 32 malic acid 31 water 29 methionine 27 Clin 26 serine 26 Glutamate 25 malic acid 25 ammonium 25 malic acid 24 carbonate 24 isocitrate 24 PEP 24 malic acid 24 calcium 21 succinic acid 21 Lactate 20 threonine 20 Mg2+ 20 Asp 18 arginine 18 manganese 17 acetic acid 17 proline 16 Insulin 16 succinic acid 15 sulfate 15 leucine 15 succinic acid 15 galactose 15 succinic acid 15 succinic acid 15 aspartic acid 14 Flux 14 His 14 cAMP 14 HCO 13 glucose-6-phosphate 13 gamma-aminobutyric acid 12 phenylacetic acid 12 asparagine 12 glutamic acid 12 cadmium 12 Glutamine 11 ornithine 11 ornithine 11 ornithine 11 cysteine 11 ornithine 11 ornithine 11 phenylacetic acid 11 SDS 11 phenylacetic acid 11 Glucagon 11 3-methylcrotonyl-CoA 11 phenylacetic acid 11 PDH 10 salt 10 potassium 10 hexose 10 hexose 10 hexose 10 hexose 10 alloxan 10 Carbon 9 oxalate 9 PYC 9 malonyl-CoA 9 dicarboxylic acid 9 3-hydroxyisovaleric acid 9 tryptophan 8 GTP 8 tryptophan 8 tryptophan 8 CIT 8 alcohol dehydrogenase 8 valine 8 nicotinamide 8 perchloric acid 8 tryptophan 8 aspartic acid 7 xylose 7 NH2 7 methanol 7 tyrosine 7 aspartic acid 7 aspartic acid 7 adenylate 7 Cereb 7 nitrate 7 hydroxycinnamic acid 7 Malate 6 zinc 6 Ile 6 nitric oxide 6 MAL 6 pyrimidine 6 Dexamethasone 6 Alanine 6 iron 6 hydrogen 6 C-3 5 PEG 5 Pyruvate kinase 5 selenium 5 2-oxobutyrate 5 2-oxobutyrate 5 Oleic acid 5 propylene glycol 4 GSH 4 GSH 4 isoleucine 4 cobalt 4 betaine 4 phosphorus 4 N-acetylaspartate 4 Phe 4 Diabetol 4 acrylamide 4 TPP 4 Propionate 4 cyanide 4 6-phosphogluconate 4 propylene glycol 4 MDA 4 acetoacetyl-CoA 3 DMI 3 copper 3 HBA 3 Tris 3 pyrimidine 3 UDP 3 PTS 3 ANA 3 iodine 3 hydrazine 3 carbamyl phosphate 3 GSSG 3 CPT 3 2-Oxoglutarate 3 PYR 3 pyridine 3 Gly 3 ANA 3 CPT 3 FAD 3 propionic acid 3 vitamin D 3 Arsenite 3 phosphocreatine 3 GDP 3 DMSO 3 MgCl2 3 creatinine 3 ACS 3 isoleucine 3 propionic acid 3 Cortisol 3 palmitoyl-CoA 3 L-threonine 3 palmitic acid 3 Fructose 3 glutaryl-CoA 3 Oxamate 3 bromide 3 ACS 3 DMI 3 propionyl-coenzyme A 3 Fumarate 3 DIM 3 Amytal 3 Sucrose 3 heptane 2 acetylglutamate 2 silver 2 phosphoric acid 2 IDP 2 chromium 2 homoserine 2 GMP 2 Neuronal 2 PAM 2 Glibenclamide 2 homoserine 2 Chlorothricin 2 MAK 2 Glyoxylate 2 NO3 2 aldehyde 2 Cycloheximide 2 GAL 2 Phenylpyruvate 2 2-phosphoglycerate 2 kaempferol 2 Optimal 2 phenyl acetate 2 TOF 2 UDP-glucose 2 COS 2 alpha-ketoisocaproate 2 benzene 2 itaconic acid 2 ACTH 2 EDTA 2 Clofibrate 2 TNF 2 PAM 2 EDTA 2 A 42 2 Lip 2 homocysteine 2 homoserine 2 L-carnitine 2 HCl 2 A 3 2 Ribulose 2 acetaldehyde 2 DDT 2 hexanoic acid 2 palmitic acid 2 oxalic acid 2 hippurate 2 DEAE 2 H2O2 2 phthalaldehyde 2 Tris 2 DCMU 2 Lead 2 GAP 2 hexanoic acid 2 quinoline 1 Rotenone 1 Benzene 1 caffeine 1 TPTA 1 uridine 1 Progesterone 1 butyric acid 1 A 1 1 MgO 1 hydroxylamine 1 Butylmalonate 1 Glu-Glu 1 PLP 1 Ethacrynic acid 1 superoxide radical 1 vanadium 1 Phytol 1 octanoic acid 1 MVA 1 Valproic acid 1 2,3-butanediol 1 Xylose 1 stearic acid 1 Galactose 1 hydroxyglutarate 1 Betula 1 Cardiol 1 Pectin 1 Dihydroxyacetone 1 Ethacrynic acid 1 sulfuric acid 1 NEM 1 acridine 1 hexuronic acid 1 CdCl2 1 DAD 1 2-hydroxyethyl carbamate 1 Metformin 1 ANS 1 ASC 1 phosphoserine 1 propionaldehyde 1 Biocytin 1 4-chlorophenyl 1 Acetyl phosphate 1 PEG 1 FFA 1 OHB 1 G3P 1 PAS 1 naphthoquinone 1 Diazoxide 1 MIC 1 benzoylformic acid 1 Thiamine 1 Homocysteine 1 benzoic acid 1 Thioredoxin 1 Coomassie Blue 1 ANS 1 Decanoylcarnitine 1 cinnamyl 1 Hypo 1 phenazine 1 Zearalenone 1 SP-1 1 1H-pyrazole 1 aluminum 1 cinnamyl 1 Metformin 1 Glycine, 1 cGMP 1 2-oxoadipate 1 prostaglandin E1 1 Leucine 1 salicylic acid 1 sodium chloride 1 2,3-butanediol 1 sulfamic acid 1 Taurine 1 decanoic acid 1 HCA 1 PBG 1 MCP 1 toluene 1 Tyrosine 1 erythrose-4-phosphate 1 Pac 1 DAG 1 sedoheptulose 7-phosphate 1 6-12 1 CPIB 1 L-leucine 1 Retinal 1 butyric acid 1 Glucose 6-phosphate 1 1-propanol 1 ribose-5-phosphate 1 Cyt 1 octanoic acid 1 CMP 1 NTA 1 naphthoquinone 1 2,4-pyrimidinediamine 1 CDP 1 sulfamic acid 1 N-acetylcysteine 1 AAT 1 PGFM 1 Triamcinolone 1 Monensin 1 octanoic acid 1 chlorine 1 Ponceau S 1 H2S 1 Bacitracin 1 butyric acid 1 Selenate 1 Methionine 1 10-formyltetrahydrofolate 1 sulfamic acid 1 Histidine 1 CIT 1 isopropanol 1 Homocysteine 1 acetone 1 octanoic acid 1 PMA 1 quinoline 1 formaldehyde 1 2-mercaptoethanol 1 Quinolinic acid 1 Choline 1 1-Methyl-4-phenylpyridinium 1 naphthoquinone 1 dimethyl malate 1 MPP 1 thiourea 1 Histone 1 Luminal 1 4-chlorophenyl 1 naphthoquinone 1 Phlorizin 1 Metribuzin 1 formaldehyde 1 stearic acid 1 meso-diaminopimelate 1 Salt 1 FDP 1 Ethoxzolamide 1 octanoic acid 1 DTB 1 Conjugated linoleic acid 1 THF 1 Amphotericin B 1 cinnamyl 1 NMDA 1 decanoic acid 1 Tamoxifen 1 hydroxylamine 1 Thyroid 1 PMS 1 Dichloroacetate 1 Fluoropyruvate 1 fructose-6-P 1 N-formimino-l-glutamate 1 nicotinic acid 1 phenylarsonic acid 1 naphthoquinone 1 Hydrazine 1 6-aminotryptophan 1 Creatine 1 2-propanol 1 Glycogen 1 adenosylmethionine 1 beta-methylcrotonic acid 1 Glycerol-3-phosphate 1 PHB 1 MPP 1 DTB 1 2,3-butanediol 1 Cefazolin 1 TPP 1 sulfamide 1 PPI 1 Nialamide 1 stearic acid 1 DNP 1 4-pentenoic acid 1 LIN 1 Glycine, 1 naphthoquinone 1 noradrenaline 1 PPi 1 dimethyl succinate 1 phenylboronic acid 1 sulfamide 1 diacetate 1 Phytol 1 norleucine 1 dihydrofolate 1 Serine 1 Hoechst 33342 1 DTB 1 MDR 1 Phorbol 1 STZ 1 Chlorogenic acid 1 CMP 1 norleucine 1 2-propanol 1 HMG-CoA 1 molybdenum 1 DSM 1 APS 1 naphthoquinone 1 Tamoxifen 1 PGA 1 TPP 1 ASA 1 Lactic acid 1 O-acetylcarnitine 1

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