Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:6.4.1.1 (pyruvate carboxylase)
 1,516 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Serum glucose, serum protein, serum glutamic oxalacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), and hepatic and renal gluconeogenic enzymes [pyruvate carboxylase (PC), phosphoenolpyruvate carboxykinase (PEPCK), fructose-1,6-diphosphatase (F-1,6-DPase), and glucose-6-phosphatase (G-6-Pase)] were determined in rats treated daily with cadmium alone (0.25 mg/kg X d, injected ip and in rats pretreated with spironolactone (50 mg/kg x d and 100 mg/kg X d, injected sc) prior to cadmium administration. Rats receiving no treatment, propylene glycol, or spironolactone (100 mg/kg X d, injected sc) were used as controls. The daily treatments were continued for an extended period of 90 d, and the rats were sacrificed at 30-, 60-, and 90-d intervals during the continuous daily treatment schedule. Cadmium treatment significantly increased the amount of serum protein, glucose, serum enzymes, and all the four key gluconeogenic enzymes as compared to controls. Pretreatment of rats with spironolactone 6 h prior to cadmium injection daily antagonized the cadmium effect of the above parameters. It appears from these results that spironolactone reduces the effects of cadmium on the key gluconeogenic enzymes in rat kidney and liver.
 ...
PMID:Influence of spironolactone on cadmium-induced changes in hepatic and renal gluconeogenic enzymes in rats. 712 May 5

Male Sprague-Dawley rats were injected intraperitoneally with 0, 0.25, 0.75 and 1.25 mg/kg/day for 14 days. At the end of 7 and 14 days treatment period, body weight gain, serum protein, serum glucose, serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) were measured. Glucose-6-phosphatase (G6-Pase), fructose-1, 6-di-phosphatase (FD-Pase), phosphoenol pyruvate carboxykinase (PEPCK) and pyruvate carboxylase (PC) in kidney and liver were determined. A significant decrease in body weight gain in rats treated with 1.25 mg cadmium for 7 and 14 days was observed. Serum glucose, serum protein, SGOT and SGPT were increased in cadmium treated rats. A significant increase in all four key gluconeogenic enzymes were observed in both kidney and liver tissues of rats treated with cadmium. The results of this study suggest that cadmium induces gluconeogenesis which is dose and time dependent.
 ...
PMID:Effect of intraperitoneally injected cadmium on renal and hepatic gluconeogenic enzymes in rats. 715 23

Male Sprague-Dawley rats were administered cadmium chloride 0, 50, 100, 150 and 200 ppm for 30 days. At the end of the treatments, the body weight gains, serum glucose, serum protein, serum glutamic oxalacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) were determined. Renal and hepatic key gluconeogenic enzymes; viz., pyruvate carboxylase, phosphoenol pyruvate carboxykinase, fructose-1, 6-diphosphatase and glucose-6-phosphatase were also determined. A significant decrease in body weight gain in rats treated with cadmium was observed. The serum glucose and protein levels were increased in rats receiving cadmium through feed. All four key gluconeogenic enzymes were increased in both kidney and liver tissues of rats treated with cadmium. The present results indicate that cadmium may induce gluconeogenesis from non-carbohydrate sources.
 ...
PMID:Cadmium induced changes in gluconeogenic enzymes in rat kidney and liver. 721