Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:6.4.1.1 (
pyruvate carboxylase
)
1,516
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Pulse labelling studies in chick embryo livers show that hemin prevents the transfer of drug induced pre-
delta-aminolevulinate synthase
from the cytosol into the mitochondria, leading to an accumulation of precursor in the cytosol. No effect of hemin was observed on the transfer of pre-
pyruvate carboxylase
into mitochondria. These results eliminated a general toxic effect of hemin on mitochondrial import of proteins and are consistent with the view that hemin specifically inhibits the transfer of
ALA synthase
.
...
PMID:Hemin inhibits transfer of pre-delta-aminolevulinate synthase into chick embryo liver mitochondria. 666 Dec 28
