Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:6.3.5.5 (
CPS
)
1,262
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Three chondroitin sulphates and five chondroitin polysulphates, with molecular weights ranging from 3000 to 30,000 daltons, were evaluated applying the
MT-4
cell-culture assay for inhibition of HIV-1 replication. These results were compared with those obtained with compounds of known in vitro antiretroviral activity, namely, dermatan sulphate, heparin, dextran sulphate, pentosan polysulphate, zidovudine (AZT) and suramin. Chondroitin polysulphate with a molecular weight (MW) of 9000 daltons (
CPS
9000) was the most effective polyanionic compound studied. In contrast with zidovudine, this
CPS
9000 was not toxic for
MT-4
cells up to a concentration of 500 micrograms/ml. Moreover,
CPS
9000 is highly specific for inhibition of HIV-1 reverse transcriptase.
...
PMID:In vitro anti-HIV-1 activity of chondroitin polysulphate. 247 44
