Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:6.3.5.5 (CPS)
 1,262 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The objective of this work was to investigate whether proteomic analysis of thymoma cells treated with the trichothecene deoxynivalenol (DON) as compared to non-treated (control) cells would reveal differential protein expression, and thus would contribute to a better understanding of the mechanisms of its toxicity. For that purpose the mouse thymoma cell line EL4 was exposed to 0.5 microM DON for 6 hr. A total of 30 proteins were affected after exposure of EL4 cells to DON. Most of these proteins were up-regulated and included key metabolic enzymes (e.g., fatty acid synthase, aldose reductase, carbamoyl phosphate synthetase, glucose-6-phosphate isomerase), chaperones (e.g., HSP9AB1 and HSP70), enzymes implicated in protein folding (PDI and ERO1-l alpha), and proteins involved in protein degradation (ubiquitin-conjugating enzyme (E1) and proteasome subunit alpha type-1). In addition, an IgE-binding protein with a molecular weight of 60 kDa and My-binding protein 1a (MYBBP1A), a transcription factor, were found to be up-regulated by DON. The observed up-regulation of MYBBP1A, a known repressor of a number of transcription factors such as PGC-1 alpha, C-myb, and p65 of the NF-kappaB family, suggests that this protein might play a role in the mechanism of DON toxicity.
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PMID:Protein expression profiling of mouse thymoma cells upon exposure to the trichothecene deoxynivalenol (DON): implications for its mechanism of action. 2067 43

Creativity is essential for success in business, especially in the contemporary world where innovations are a cornerstone of competitive advantage. A large body of literature has examined many factors which influence creative abilities with the work environment being the factor of increasing importance. Creativity has been associated with the work environment through a number of theoretical frameworks and empirical studies. However, the relationship between the work environment and creativity in different cultures has not been explored sufficiently. This paper addresses this gap in the literature by linking the concept of a creativity-supporting work environment and culture. To that end, elements of the work environment (physical, socio-organisational, and fun in the workplace) and creative personality have been analysed on multinational samples. The results clearly point that the relationship exists between dimensions of the national culture (individualism, uncertainty avoidance, masculinity, and power distance) and specific elements of a creativity-supporting work environment. Practitioner summary: Companies experience high pressure for generating creative ideas. As a result, stimulating employees' creativity has become a key strategic aim. This study, through cross-cultural primary research, provides clear managerial implications and practical advice for successful implementation and quality adoption of the creativity-supporting work environment worldwide. Abbreviations: A-FOs: activity-based flexible offices; AVG: average; CDQS: creativity development quick scan; CP: creative personality; CPS: creative personality scale; FWP: fun in the workplace; HF/E: human factors and ergonomics; IDV: individualism; MAS: masculinity; MBA: Master of Business Administration; PDI: power distance; PWE: physical work environment; SWE: socio-organisational work environment; UAI: uncertainty avoidance; USA: United States of America; WE: work environment.
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PMID:The influence of cultural dimensions when implementing fun in the workplace approach as a driver of creativity. 3103 99