Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:6.3.5.5 (CPS)
 1,262 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The influence of cyproterone acetate (CPS) containing drugs on the endometrium has not yet been investigated. Therefore, endometrial biopsies were obtained in 22 hirsute patients between days 14-28 of the cycle after 7-18 months of antiandrogen oral therapy. The effects of various regimens consisting of different doses of CPA in combination with ethinyl estradiol (EE) were evaluated. The low dose standard regimen (50 mcg EE plus 2 mg CPA daily from days 5-25) caused regressive changes in the endometrium; i.e., sparse atrophic glands, relatively compact stroma, islands of stromal edema. These alterations correspond to those induced by conventional balanced low dose combined oral contraceptives. High dose reversed sequential regimen (40 mcg of EE daily from days 5-25 plus 100 mg CPA daily from days 5-14) resulted in pseudodeciduation and massive stromal edema. Pseudodeciduation during the early secretory phase is taken as a sign of the progestational depot effect of CPA, while the stromal edema is regarded as a result of the relatively unopposed estrogen intake during the 2nd 1/2 of the treatment cycle. Thus, the effects of a CPA containing drug on the endometrium depend essentially on their type, dosage, and mode of administration.
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PMID:Effects of cyproterone acetate and ethinylestradiol on endometrial histology. 666 41

We study the optical response of a double optomechanical cavity system assisted by two Rydberg atoms. The target atom is only coupled with one side cavity by a single cavity mode, and gate one is outside the cavities. It has been realized that a long-range manipulation of optical properties of a hybrid system, by controlling the Rydberg atom decoupled with the optomechanical cavity. Switching on the coupling between atoms and cavity mode, the original spatial inversion symmetry of the double cavity structure has been broken. Combining the controllable optical non-reciprocity with the coherent perfect absorption/transmission/synthesis effect (CPA/CPT/CPS reported by [ X.-B.Yan Opt. Express 22, 4886 (2014)], we put forward the theoretical schemes of an all-optical transistor which contains functions such as a controllable diode, rectifier, and amplifier by controlling a single gate photon.
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PMID:All-optical transistor based on Rydberg atom-assisted optomechanical system. 2971 44

We are teetering on the precipice of the imminent Fourth Industrial Revolution. In this new age, systems are set to become more densely intraconnected and interconnected, and massive sociotechnical systems exhibiting unprecedented levels of complexity will increasingly take hold. At the dawning of this new age, the Ergonomics discipline must reflect on its preparedness for tackling problems in these novel systems. This paper engages in this reflection by putting forth a critical commentary on the implication of these changes on the discipline and discusses the utility of our current methods in this new paradigm. A resulting Radical Systems Thinking in Ergonomics Manifesto is put forward - a set of mandates to guide practitioners and researchers in the development of new methods capable of coping with these imminent challenges. From the manifesto are derived a series of capability requirements for future computational modelling approaches in Ergonomics. Practitioner summary: The goal of this paper was to inspire the Ergonomics community to pursue further applications involving computational modelling approaches such as Agent-Based Modelling. It presents a manifesto for the future of the discipline, and from this the capabilities that future computational modelling approaches need to possess. Abbreviations: 1IR: first industrial revolution; 2IR: second industrial revolution; 3IR: third industrial revolution; 4IR: fourth industrial revolution; ABM: agent based model; AI: artificial intelligence; AoF: allocation of function; CPA: cyber physical attack; CPS: cyber-physical system; CWA: cognitive work analysis; DDoS: distributed denial of service; EAST: event analysis of systemic teamwork; FRAM; functional resonance analysis method; HCI: human-computer interaction; HERA: human error and recovery assessment; HET: human error template; HMC: human-machine cooperation; IoT: internet of things; RSTEM: radical systems thinking in ergonomics manifesto; SAI: situated artificial intelligence; STAMP: systems theoretic accident model and processes; TRACEr: technique for the retrospective and predictive analysis of cognitive errors in air traffic control.
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PMID:Radical systems thinking and the future role of computational modelling in ergonomics: an exploration of agent-based modelling. 3172 86