Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:6.3.5.5 (CPS)
 1,262 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A simple, reliable, compact and sensitive detection system was required to measure the position as a function of time of local concentrations of tracers tagged with 99Tcm as they are transported up the trachea by mucociliary activity. A multidetector probe to meet these requirements was designed and constructed: it consists of three pairs of NaI(Tl)/CsI(Na) phoswich sandwiches arranged in line so that measurements of response in six positions can be made. Each crystal was 8 mm thick, 1.5 mm deep and formed an arc of 90 degrees with an internal radius of 7 cm. Spatial resolution and background reduction were achieved by pulse height and pulse shape analysis and the use of tungsten parallel-plate collimators. At the face of the collimators the system had a spatial resolution of 9 mm FWHM and a sensitivity of 3.78 X 10(-2) CPS Bq-1 (1400 CPS microCi-1). Background radiation response was typically 1 CPS per crystal. Determinations of tracheal mucus velocity have been made in man. This multidetector probe could be adapted to other velocity measurements over an extended range and for the measurement of activity profiles when high sensitivity is desired.
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PMID:A phoswich multidetector probe for measuring tracheal mucus velocity. 652 99