Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:6.3.5.5 (
CPS
)
1,262
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We have previously shown that the peptide FDTGAFDPDWPA is a mimetic of the group B streptococcal type III capsular polysaccharide (
CPS
(III)). It binds to anti-
CPS
(III) antibodies and can be used to immunize mice and produce anti-
CPS
(III). In this paper we investigate the molecular mechanisms underlying this peptide-carbohydrate
mimicry
in two ways. First, we have examined the conformation of the peptide by NMR spectroscopy in water. Next, we have produced monoclonal anti-peptide and anti-
CPS
(III) antibodies, compared their fine specificity, and have sequenced them. The results indicate that the peptide assumes a conformation that may be similar to that of the
CPS
(III) in solution and that the peptide and
CPS
(III) elicit an overlapping repertoire of antibodies.
...
PMID:Initial studies of the molecular basis of peptide mimicry of group B streptococcal type III capsular polysaccharide. 1187 66
