Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:6.3.4.6 (urease)
 7,490 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Weanling rats were fed low-fat (1% w/w safflower oil) or high-fat (1% w/w safflower oil plus 35% w/w beef fat or cocoa butter) diets for 30 days, and the activities of five cecal microbial enzymes were determined. When compared with the low-fat diet, beef fat significantly increased total cecal beta-glucuronidase activity, but cocoa butter, with a similar fatty acid composition, did not. Both high-fat diets significantly decreased total cecal azoreductase, beta-glucosidase, and nitrate reductase activities, but neither significantly affected urease activity. When expressed as specific activities (per 10(11) bacteria), cocoa butter decreased azoreductase, and beef fat caused increases of beta-glucuronidase and urease. Beef fat, but not cocoa butter, significantly reduced cecal bacterial numbers when compared to the low-fat diet. Both high-fat diets led to equivalent reductions in the proportion of aerobic bacteria.
 ...
PMID:Dietary fat and cecal microbial activity in the rat. 654 72

Contamination of agricultural soil with Cd has become a global concern because of its adverse effects on eco-health and food safety. Soil amendments with biochar have become one of the phytotechnology to reduce soil metal phyto-availability and their potential risk along the food chain. Biochar (BC), derived from cocoa-pod, was evaluated on soil Cd fractions (exchangeable, reducible, oxidisable and residual) by modified BCR sequential extraction and its efficacy to ameliorate Cd toxicity to soil enzymes and leaf bioactive compounds. A pot experiment was conducted using Cd-spiked soil at 10 mg/kg with tomato (Solanum lycopersicum L.) at BC applicate rate of 1 and 3% (w/w) for 6 wk. The addition of biochar significantly reduced (p<0.05) the exchangeable, reducible and residual fractions by at least ~23% with consequential decrease in Cd root uptake and transport within tomato tissues. The activity of soil enzymes (catalase, dehydrogenase, alkaline phosphatase and urease) was affected by Cd toxicity. However, BC application significantly enhanced the enzymes activities, especially at 3% (w/w) rate except for dehydrogenase. Toxicity of Cd was observed on glutathione, terpenoids and total phenols out of the studied secondary metabolites. However, BC application rate of 1% (w/w) significantly ameliorated the effect of toxicity on the secondary metabolites. In conclusion, the biochar demonstrated potentials to act as soil amendments for Cd immobilization and thereby reduced its bioavailability in soil to mitigate food security risks. This article is protected by copyright. All rights reserved.
 ...
PMID:Short-Term Ageing of Pod-Derived Biochar Reduced Soil Cadmium Mobility and Ameliorated Cadmium Toxicity to Soil Enzymes and Tomato. 3328 39