Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:6.3.4.6 (
urease
)
7,490
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Helicobacter pylori
infects the human stomach and causes a spectrum of disease that includes gastritis, peptic ulcers, and gastric adenocarcinoma. A chronic, neutrophil-rich inflammatory response characterizes this infection. It is established that
H. pylori
stimulates neutrophil chemotaxis and a robust respiratory burst, but other aspects of this interaction are incompletely defined. We demonstrate here that
H. pylori
induces N1-like subtype differentiation of human neutrophils as indicated by profound nuclear hypersegmentation, a CD62L
dim
, CD16
bright
, CD11b
bright
, CD66b
bright
,
CD63
bright
surface phenotype, proinflammatory cytokine secretion, and cytotoxicity. Hypersegmentation requires direct neutrophil-
H. pylori
contact as well as transcription and both host and bacterial protein synthesis, but not
urease
, NapA, VacA, CagA, or CagT. The concept of neutrophil plasticity is new and, to our knowledge, these data are the first evidence that neutrophils can undergo subtype differentiation in vitro in response to bacterial pathogen infection. We hypothesize that these changes favor
H. pylori
persistence and disease.
...
PMID:Cutting Edge:
Helicobacter pylori
Induces Nuclear Hypersegmentation and Subtype Differentiation of Human Neutrophils In Vitro. 2814 34
