Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:6.3.4.6 (
urease
)
7,490
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
In this study, the effects of alginate modification on absorption properties of FITC-BSA loaded
TMC
nanoparticles were investigated on an in vitro model of GI epithelium (Caco-2 cells). The feasibility of applying
TMC
nanoparticles loaded with a model vaccine
urease
in oral vaccination was also studied. Alginate modified
TMC
nanoparticles showed higher FITC-BSA permeate efficiency than non-modified
TMC
nanoparticles. However, alginate modification barely had any effect on
TMC
nanoparticles' property of decreasing TEER or enhancing drug paracellular transport. Mice s.c. immunized with
urease
loaded
TMC
nanoparticles showed highest systematic immune response (IgG levels) but the lowest mucosal response (secretory IgA levels). In the contrast, mice i.g. immunized with
urease
loaded
TMC
nanoparticles showed much higher antibody titers of both IgG and secretory IgA than those with
urease
solution or
urease
co-administrated with
TMC
solution. These results indicated that
TMC
nanoparticles are potential carriers for oral protein and vaccine delivery.
...
PMID:In vitro and in vivo study of N-trimethyl chitosan nanoparticles for oral protein delivery. 1782 6
