Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:6.3.4.6 (urease)
 7,490 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Hyphomicrobium species are able to use allantoin as a nitrogen source for growth. Allantoin is broken down to glyoxylate and ammonia by the consecutive action of allantoinase, allantoicase, ureidoglycolase and urease.
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PMID:Metabolism of allantoin in Hyphomicrobium species. 733 36

Allantoin catabolism studies have been extended to intact leaf tissue of soybean (Glycine max L. Merr.). Phenyl phosphordiamidate, one of the most potent urease inhibitors known, does not inhibit (14)CO(2) release from [2,7-(14)C]allantoin (urea labeled), but inhibits urea dependent CO(2) release >/=99.9% under similar conditions. Furthermore, (14)CO(2) and [(14)C] allantoate are the only detectable products of [2,7-(14)C]allantoin catabolism. Neither urea nor any other product were detected by analysis on HPLC organic acid or organic base columns although urea and all commercially available metabolites that have been implicated in allantoin and glyoxylate metabolism can be resolved by a combination of these two columns. In contrast, when allantoin was labeled in the two central, nonureido carbons ([4,5-(14)C]allantoin), its catabolism to [(14)C]allantoate, (14)CO(2), [(14)C]glyoxylate, [(14)C]glycine, and [(14)C]serine in leaf discs could be detected. These data are fully consistent with the metabolism of allantoate by two amidohydrolase reactions (neither of which is urease) that occur at similar rates to release glyoxylate, which in turn is metabolized via the photorespiratory pathway. This is the first evidence that allantoate is metabolized without urease action to NH(4) (+) and CO(2) and that carbons 4 and 5 enter the photorespiratory pathway.
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PMID:Ureide Catabolism of Soybeans : II. Pathway of Catabolism in Intact Leaf Tissue. 1666 92