Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:6.3.4.6 (urease)
 7,490 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

On the basis of biochemical, phenotypic, and 16S rRNA analysis, a novel gram-negative bacterium, isolated from normal and diarrheic dogs as well as humans with gastroenteritis, has been recently named Helicobacter canis. A 2-month-old female crossbred puppy was submitted to necropsy with a history of weakness and vomiting for several hours prior to death. The liver had multiple and slightly irregular yellowish foci up to 1.5 cm in diameter. Histologically, the liver parenchyma contained randomly distributed, occasionally coalescing hepatocellular necrosis, often accompanied by large numbers of mononuclear cells and neutrophils. Sections of liver stained by the Warthin-Starry silver impregnation technique revealed spiral- to curve-shaped bacteria predominantly located in bile canaliculi and occasionally in bile ducts. Aerobic culture of liver was negative, whereas small colonies were noted on Campylobacter selective media after 5 days of microaerobic incubation. The bacteria were gram negative and oxidase positive but catalase, urease, and indoxyl acetate negative; nitrate was not reduced to nitrite, and the organism did not hydrolyze hippurate. The bacteria were also resistant to 1.5% bile. Electron microscopy revealed spiral-shaped bacteria with bipolar sheathed flagella. By 16S rRNA analysis, the organism was determined to be H. canis. This is the first observation of H. canis in active hepatitis in a dog and correlates with recent findings of Helicobacter hepaticus- and Helicobacter bilis-related hepatic disease in mice. Further studies are clearly warranted to ascertain whether H. canis-associated hepatitis is more widespread in canines as well as a cause of previously classified idiopathic liver disease in humans.
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PMID:Helicobacter canis isolated from a dog liver with multifocal necrotizing hepatitis. 888 May 4

Helicobacter pylori causes one of the most common infections in human populations. The role of this bacterium in chronic gastritis, gastric ulcer, gastric cancer, as well as extra-digestive diseases such as ischemic heart disease and chronic obstructive pulmonary diseases, is well known. Prevention and control of these diseases can occur by early diagnosis and eradication of H. pylori infection. At present, different methods have been established to detect H. pylori infection. The biopsy-based tests, which are known as invasive methods, such as rapid urease test and histology, have the highest specificity among the others. Similarly, culture of biopsy samples is used for diagnosis of H. pylori infection. It has a high specificity value, and also allows us to perform antibiotic sensitivity testing. On the contrary, polymerase chain reaction and other molecular methods have good sensitivity and specificity, and can be used for detection of H. pylori infection, its virulence factors, and eradication success after treatment. While serological tests are more appropriate for epidemiological studies, their main weakness for clinical use is low specificity. Overall, specificity and sensitivity, cost, usefulness, and limitation of tests should be considered for selection of detection methods of H. pylori in each country.
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PMID:The Diagnostic Tests for Detection of Helicobacter pylori Infection. 3064 11

Nocardia is a Gram-positive, partially acid-fast, catalase-positive, and urease-positive bacterium that grows aerobically. We present an extremely rare case of cauda equina syndrome due to isolated intramedullary Nocardia farcinica infection. A 44-year-old male presented with low backache and gradually progressive weakness in bilateral lower limbs followed by paraplegia. He was found to have a well-defined, sharply demarcated ring-enhancing lesion located from T11-T12 to L3 vertebral body. He underwent laminectomy and decompression. The histopathological examination revealed a Gram-positive filamentous organism that looks like Nocardia. The culture report was suggestive of Nocardia farcinica. He was then treated with antibiotics and had a remarkable clinical and radiological improvement.
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PMID:A rare case of isolated cauda equina Nocardia farcinica infection. 3254 51

The improper handling of decrypted information will lead to the second leakage of confidential data. Thus, there is an ever-increasing interest yet grand challenge in developing a new strategy of self-erasing decrypted data. Here we address this challenge by designing urease catalysis in hydrogel with spatiotemporal regulation for multistage information security protection. We fabricated fluorescent hydrogel based on the protonated 4-(N,N-dimethylaminoethylene) amino-N-allyl-1,8-naphthalimide (DEAN-H + ), doping with urease as a urea responsive catalysis system that can produce NH 3 in spatiotemporal regulation with a subsequent fluorescence weakness due to the photoinduced electron transfer (PET) effect triggered by the deprotonation of naphthalimide moieties. Upon the information input using metal ions such as Zn 2+ that can coordinate with DEAN in hydrogel to maintain the fluorescence properties, which could be slowly weakened by the urease catalysis compared with the fast weak process of DEAN-H + hydrogel in urea solution. Therefore, taking advantage of time variety, encrypted information on the hydrogel could be decrypted in urea solution, and the displayed information could be automatically erased within a few minutes on the basis of the step wisely fluorescence off behavior. This work opens up a new insights in designing and fabricating information storage materials for Snapchat (disappear after reading) to against rising problems in counterfeiting.
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PMID:Spatiotemporal regulation of fluorescence in a urease-embedded hydrogel for multistage information security. 3313 51