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Query: EC:6.3.4.6 (urease)
 7,490 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In this review, methodological aspects of cerebral perfusion imaging with ultrasound contrast agents are described. The various experimental concepts contributing to an understanding of the phenomena are summarised and the resulting investigation techniques on patients are illustrated. By means of harmonic imaging, human cerebral perfusion can be depicted as a two-dimensional scan. The two major principles of contrast measurement are analysis of the bolus kinetics and analysis of the refill kinetics. Using the bolus method, hypoperfused areas in stroke patients can be visualised and parameter images of wash-in and wash-out curves can be generated off-line. The recently developed theory on the refill kinetics of UCA enables us to calculate parameters for describing the cerebral microcirculation, as they are less affected by the depth dependence of the contrast effect. These parameters can also be visualised as images. The ultrasound methods described in this article represent new minimally invasive bedside techniques for analysing brain perfusion. Although their development is still in an early stage, the potential of these ultrasound technologies to compete with perfusion CT, perfusion MRI, and SPECT in the diagnostic arsenal of brain imaging techniques is becoming evident.
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PMID:[Harmonic imaging. A new method of ultrasound imaging of brain perfusion]. 1151

In this review, methodological aspects of cerebral perfusion imaging with ultrasound signal enhancing agents are described. The various experimental bases, contributing to the understanding of the phenomena are summarised and the resulting human investigation techniques are illustrated. By means of harmonic imaging technology, human cerebral perfusion can be depicted as a two-dimensional scan. The two major principles of contrast measurement are analysis of the bolus kinetics and analysis of the refill kinetics. Using the bolus method, hypoperfused areas in stroke patients can be visualised and parameter images of wash-in and wash-out curves can be generated off-line. The recently developed theory on the refill kinetics of UCA enables us to calculate quantitative parameters for the description of the cerebral microcirculation, being less affected by the depth dependence of the contrast effect. These parameters, too, can be visualised as parameter images. The ultrasound methods described in this article represent new minimal-invasive bedside techniques for analysing brain perfusion. Although their development is still in an early state, the potential of these ultrasound technologies to compete with perfusion-CT, perfusion-MRI or single-photon emission computed tomography in the diagnostic arsenal of brain imaging techniques is becoming evident.
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PMID:Harmonic imaging--a new method for the sonographic assessment of cerebral perfusion. 1170 27

Helicobacter pylori (H. pylori) is the commonest bacterial pathogen found worldwide and more than half the world population aged 40 years and above is colonized with it. The infection rate is >95 % in some African countries. In 1994, the International Agency for Research on cancer classified H. pylori as a class I carcinogen in humans. It causes chronic active gastritis, duodenal and gastric ulcer and gastric malignancy, and is thought to be associated with coronary artery disease, cerebral stroke, vitamin B12 and iron-deficiency anaemia, etc. Therefore, non-invasive test-and-treatment strategies are widely recommended in primary care settings. Conventionally, H. pylori infection can be diagnosed by invasive techniques using an upper gastrointestinal endoscope for obtaining multiple biopsies from different sites of the stomach for RUT, culture, histological examination, polymerase chain reaction (PCR), etc. and by non-invasive tests such as Urea breath test (UBT), stool antigen test and blood serology. At present, 13/14C-UBT is considered the test of choice for confirmation of H. pylori infection. The UBT is based on the principle, that isotopically labelled urea ingested by an H. pylori--infected patient is rapidly hydrolysed by the microbial urease. The released 13/14CO2 is absorbed across the mucous layer to the gastric mucosa and hence, excreted via the systemic circulation in the breath which is collected and measured. The non-hydrolysed urea is excreted completely in the urine within 3-4 days. 13C-UBT being non-radioactive, 13C-UBT can be used in pregnant women and children, and a user's license is not required. There is still no standard protocol accepted and followed internationally for this test. Although the methods are almost similar, various laboratories/clinics use variable tracer doses, test meals, timings and methods for breath collection, and different cut-off values, which make formal validation studies necessary. This review describes the present status of the UBT and its application in the detection of H. pylori infection.
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PMID:Urea breath test for Helicobacter pylori detection: present status. 1591 72